Now showing items 1-10 of 27
Synergistic effect of hydrotrope and surfactant on solubility and dissolution of atorvastatin calcium : Screening factorial design followed by ratio optimization
The present study was aimed at investigating the effect of hydrotrope and surfactant on poor solubility of atorvastatin calcium. Excipients screening followed by factorial design was performed to study effect of excipients ...
Computational classification models for predicting the interaction of drugs with P-glycoprotein and breast cancer resistance protein
P-glycoprotein (P-gp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) are two members of the adenosine triphosphate (ATP) binding cassette (ABC) family of transporters which function as membrane efflux transporters ...
Children's physical activity assessed with wrist- and hip-worn accelerometers
Recently, triaxial raw acceleration accelerometers have become available from GENEActiv and ActiGraph; both are designed for wrist and hip wear. It is important to determine whether the output from these monitors is ...
Structural insights into binding of small molecule inhibitors to Enhancer of Zeste Homolog 2
Enhancer of Zeste Homolog 2 (EZH2) is a SET domain protein lysine methyltransferase (PKMT) which has recently emerged as a chemically tractable and therapeutically promising epigenetic target, evidenced by the discovery ...
PAR-1 antagonist vorapaxar favorably improves global thrombotic status in patients with coronary disease
To assess the effect of vorapaxar on global thrombotic and thrombolytic status. The propensity for thrombus formation is determined by the balance between prothrombotic factors and endogenous thrombolysis. Impaired ...
Evidence That Self-Affirmation Improves Phosphate Control in Hemodialysis Patients : A Pilot Cluster Randomized Controlled Trial
Hemodialysis patients are at risk of serious health complications, yet treatment non-adherence remains high.
The surgical treatment of rheumatoid arthritis : a new era?
There has been an in increase in the availability of effective biological agents for the treatment of rheumatoid arthritis as well as a shift towards early diagnosis and management of the inflammatory process. This article ...
Becoming a Performance Analyst : Autoethnographic Reflections on Agency, and Facilitated Transformational Growth
This paper features an autoethnographic approach in presenting and reflecting upon the story of one higher education student’s rapid vocational and academic transformation. Initially an inconspicuous undergraduate student, ...
Rheumatoid Arthritis-related interstitial lung disease : associations, prognostic factors and physiological and radiological characteristics - a large multicentre UK study
The prevalence of interstitial lung disease (ILD) in RA is ∼5%. Previous work identified increasing age, active articular disease and articular damage as risk factors for RA-associated ILD (RA-ILD). The roles of high-resolution ...
The impact of different footwear characteristics, of a ballet flat pump, on centre of pressure progression and perceived comfort
BACKGROUND: Uncomfortable shoes have been attributed to poor fit and the cause of foot pathologies. Assessing and evaluating comfort and fit have proven challenging due to the subjective nature. The aim of this paper is ...