Now showing items 1-10 of 115
Role of prostacyclin in pulmonary hypertension
Prostacyclin is a powerful cardioprotective hormone released by the endothelium of all blood vessels. Prostacyclin exists in equilibrium with other vasoactive hormones and a disturbance in the balance of these factors leads ...
Synergistic effect of hydrotrope and surfactant on solubility and dissolution of atorvastatin calcium : Screening factorial design followed by ratio optimization
The present study was aimed at investigating the effect of hydrotrope and surfactant on poor solubility of atorvastatin calcium. Excipients screening followed by factorial design was performed to study effect of excipients ...
The PPARβ/δ agonist GW0742 prevents LPS-induced nitrite production in rat parenchyma but not in aorta or pulmonary arteries
Peroxisome Proliferator activated receptors (PPARs) are therapeutic targets in the treatment of inflammatory lung disease. The PPARβ/δ agonist GW0742 has potent anti-inflammatory effects in the vasculature (Kapoor et al ...
AWARE-AWAreness during REsuscitation-A prospective study
Background: Cardiac arrest (CA) survivors experience cognitive deficits including post-traumatic stress disorder (PTSD). It is unclear whether these are related to cognitive/mental experiences and awareness during CPR. ...
Computational classification models for predicting the interaction of drugs with P-glycoprotein and breast cancer resistance protein
P-glycoprotein (P-gp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) are two members of the adenosine triphosphate (ATP) binding cassette (ABC) family of transporters which function as membrane efflux transporters ...
What prize for curing Alice's tears?
Reviews the quality of the evidence for using CBT for depression in young people
Children's physical activity assessed with wrist- and hip-worn accelerometers
Recently, triaxial raw acceleration accelerometers have become available from GENEActiv and ActiGraph; both are designed for wrist and hip wear. It is important to determine whether the output from these monitors is ...
Phoma stem canker disease on oilseed rape (Brassica napus) in China is caused by Leptosphaeria biglobosa ‘brassicae’
Phoma stem canker of oilseed rape (Brassica napus) is a globally important disease that is caused by the sibling ascomycete species Leptosphaeria maculans and L. biglobosa. Sixty fungal isolates obtained from oilseed rape ...
Effects of workplace-based dietary and/or physical activity interventions for weight management targeting healthcare professionals : a systematic review of randomised controlled trials
BACKGROUND: The prevalence of overweight and obesity is high amongst healthcare professionals and there is growing interest in delivering weight loss interventions in the workplace. We conducted a systematic review to (i) ...