Now showing items 1-10 of 117
Disc-shaped polyoxyethylene glycol glycerides gel nanoparticles as novel protein delivery vehicles
Disc-shaped nanoparticles with high aspect ratios have been reported to show preferential cellular uptake in vitro by mammalian cells. However, engineering and producing such disc-shaped nanoparticles are often complex. ...
The streptozocin model of diabetes induces neuropathic pain, anhedonia and impaired burrowing in rats
Many diabetic patients experience chronic neuropathic pain leading to a reduced quality of life which poses a huge economic burden to the health system and society. There is a dire need to develop more efficacious analgesics ...
Global Thrombosis Test - a possible monitoring system for the effects and safety of dabigatran
BACKGROUND: Dabigatran is an alternative to warfarin (WF) for the thromboprophylaxis of stroke in patients with non-valvular atrial fibrillation (NVAF). The advantage of dabigatran over WF is that monitoring is not required; ...
Molecular modeling of influenza A virus proteins
Plasma Levels of Middle Molecules to Estimate Residual Kidney Function in Haemodialysis without Urine Collection
BACKGROUND: Residual Kidney Function (RKF) is associated with survival benefits in haemodialysis (HD) but is difficult to measure without urine collection. Middle molecules such as Cystatin C and β2-microglobulin accumulate ...
An exploration of the language used alongside the Process for Nutrition and Dietetic Practice (PNDP) to describe nutrition-related problems
An exploration of the language used alongside the Process for Nutrition and Dietetic Practice (PNDP) to describe nutrition-related problemsR Lindop1 & J McClinchy21Shrewsbury and Telford Hospitals Trust, The Royal Shrewsbury ...
Predicting fatty acid profiles in blood based on food intake and the FADS1 rs174546 SNP
SCOPE: A high intake of n-3 PUFA provides health benefits via changes in the n-6/n-3 ratio in blood. In addition to such dietary PUFAs, variants in the fatty acid desaturase 1 (FADS1) gene are also associated with altered ...
An evaluation of key working for families of children and young people with special educational needs and disabilities
Key working is a way of supporting children and young people with special educational needs and disabilities (SEND) and their families, and is highly regarded by families and practitioners. However, there is a lack of ...
Social-ecological systems in the Anthropocene : the need for integrating social and biophysical records at regional scales
Understanding social-ecological system dynamics is a major research priority for sustainable management of landscapes, ecosystems and resources. But the lack of multi-decadal records represents an important gap in information ...