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Hyperconnectivity of the ventromedial prefrontal cortex in obsessive-compulsive disorder
(2018-11-30)
Neuroimaging research has highlighted maladaptive thalamo-cortico-striatal interactions in obsessive-compulsive disorder as well as a more general deficit in prefrontal functioning linked with compromised executive ...
Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells
(2018-11-19)
Limited access to human islets has prompted the development of human beta cell models. The human beta cell lines EndoC-βH1 and EndoC-βH2 are increasingly used by the research community. However, little is known of their ...
Appraisal of patient-reported outcome measures in analogous diseases and recommendations for use in phase II and III clinical trials of pyruvate kinase deficiency
(2018-11-19)
Purpose: Pyruvate kinase deficiency (PKD) is a rare disease and understanding of its epidemiology and associated burden remains limited. With no current curative therapy, clinical manifestations can be life threatening, ...
Knockdown of a mucin-like gene in Meloidogyne incognita (Nematoda) decreases attachment of endospores of Pasteuria penetrans to the infective juveniles and reduces nematode fecundity : Mucin-like gene from M. incognita
(2018-11-01)
Mucins are highly glycosylated polypeptides involved in many host–parasite interactions, but their function in plant-parasitic nematodes is still unknown. In this study, a mucin-like gene was cloned from Meloidogyne incognita ...
Intravenous Iron in Patients Undergoing Maintenance Hemodialysis
(2018-10-26)
BACKGROUND: Intravenous iron is a standard treatment for patients undergoing hemodialysis, but comparative data regarding clinically effective regimens are limited. METHODS: In a multicenter, open-label trial with blinded ...
Quality, Non-clinical and Clinical Considerations for Biosimilar Monoclonal Antibody Development: EU, WHO, USA, Canada, and BRICS-TM Regulatory Guidelines
(2018-09-28)
Objective: The aim was to critically evaluate well-established regulatory agencies mAb biosimilar guidelines for development and marketing authorization about quality, efficacy and safety and compare to BRICS-TM regulations ...
The future of robotic surgery
(2018-09-01)
For 20 years Intuitive Surgical’s da Vinci® system has held the monopoly in minimally invasive robotic surgery. Restrictive patenting, a well-developed marketing strategy and a high-quality product have protected the ...
Pharmacoeconomic evaluation and its application in clinical guideline development
(2018-08-11)
Pharmacoeconomic evaluation is an analysis technique that combines data on both costs and health outcomes to allow clinical decision makers to assess the cost effectiveness of pharmaceutical products and services. It is ...
Exploring formalized elite coach mentoring programmes in the UK: ‘We’ve had to play the game’
(2018-07-04)
Formalized mentoring programmes have been implemented increasingly by UK sporting institutions as a central coach development tool, yet claims supporting formal mentoring as an effective learning strategy are often ...