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Modules for Automated Validation and Comparison of Models of Neurophysiological and Neurocognitive Biomarkers of Psychiatric Disorders: ASSRUnit - A Case Study Computational Psychiatry
The characterisation of biomarkers and endophenotypic measures has been a central goal of research in psychiatry over the last years. While most of this research has focused on the identification of biomarkers and ...
Nonspecific synaptic plasticity improves the recognition of sparse patterns degraded by local noise
Many forms of synaptic plasticity require the local production of volatile or rapidly diffusing substances such as nitric oxide. The nonspecific plasticity these neuromodulators may induce at neighboring non-active synapses ...
Distinctive Role of KV1.1 Subunits in the Biology and Functions of Low Threshold K+ Channels with Implication for Neurological Disease
The diversity of pore-forming subunits of KV1 channels (KV1.1–KV1.8) affords their physiological versatility and predicts a range of functional impairments resulting from genetic aberrations. Curiously, identified so far ...
Information theoretical analysis of differences in information transmission in cerebellar Purkinje cells across species
The dendrite of the cerebellar Purkinje cell is one of the most complex structures in the mammalian brain, receiving more than 150,000 synaptic inputs. It is also one of the most extensively modelled neurons in the mammalian ...