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Now showing items 16692-16711 of 24199
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Pharmacokinetic and pharmacodynamic profiles of danofloxacin administered by two dosing regimens in calves infected with Mannheimia (Pasteurella) haemolytica
(2002-09)The pharmacokinetics and pharmacodynamics of danofloxacin in calves with induced Mannheimia (Pasteurella) haemolytica pneumonia were evaluated. Calves received either saline as an intravenous (IV) bolus or danofloxacin ... -
Pharmacokinetic and pharmacodynamic studies on phenylbutazone and oxyphenbutazone in goats
(1997)Phenylbutazone was administered intravenously and orally to six goats as a single dose of 4.4 mg/kg and its disposition and bioavailability and the disposition of its active metabolite, oxyphenbutazone, in plasma were ... -
Pharmacokinetic evaluation of intranasally administered vinyl coated lorazepam microparticles in rabbits
(2012)The intranasal (IN) administration of lorazepam is desirable in order to maximize speed of onset and minimise carry-over sedation; however, this benzodiazepine is prone to chemical hydrolysis and poor airway retention, and ... -
Pharmacokinetic features of the antiparasitic macrocyclic lactones
(2012-05)The macrocyclic lactones have pharmacokinetic properties which enhance their use against endo- and ectoparasites in animals and man. The most consistent physico-chemical feature of the group which contributes to their ... -
Pharmacokinetic studies of flunixin meglumine and phenylbutazone in plasma, exudate and transudate in sheep
(1998-08)Flunixin meglumine (FM, 1.1 mg/kg) and phenylbutazone (PBZ, 4.4 mg/kg) were administered intravenously (i.v.) as a single dose to eight sheep prepared with subcutaneous (s.c.) tissue-cages in which an acute inflammatory ... -
Pharmacokinetic, biochemical and tolerance studies on carprofen in the horse
(1991-07)Carprofen, a non-steroidal anti-inflammatory drug (NSAID) was administered to three Thoroughbred geldings and three Shetland ponies to determine its plasma disposition and tolerance. The main pharmacokinetic characteristics ... -
Pharmacokinetic/pharmacodynamic relationships of antimicrobial drugs used in veterinary medicine
(2004-12)The rise in incidence of antimicrobial resistance, consumer demands and improved understanding of antimicrobial action has encouraged international agencies to review the use of antimicrobial drugs. More detailed understanding ... -
Pharmacokinetics and applications of ampicillin sodium as an intravenous infusion in the horse
(1993-03)A regime for administration of ampicillin sodium by continuous intravenous infusions to horses was designed. The aim was to achieve plasma ampicillin concentrations between 5 and 10 micrograms/ml over a 4-h period. A 2 ... -
Pharmacokinetics and clinical effects in dogs of a sustained-release formulation of theophylline
(1993-08)Theophylline was administered orally in a sustained-release preparation at a dose rate of 20 mg/kg bodyweight to six beagle dogs. A mean (+/- se) maximum plasma concentration of 12.2 +/- 0.65 micrograms/ml was obtained ... -
Pharmacokinetics and clinical efficacy of a cinchophen and prednisolone combination in the dog
(1991-02)The kinetics and efficacy of a cinchophen prednisolone combination preparation (PLT) were assessed in the dog. Cinchophen administered at a dose rate of 12-5 mg/kg intravenously had a volume of distribution (Vd area) of ... -
Pharmacokinetics and pharmacodynamics of piroxicam in dogs
(1991-06)Piroxicam was administered to beagle dogs intravenously and orally at a dose rate of 0.3 mg/kg bodyweight. It had an elimination half-life of 40.2 hours, a volume of distribution of 0.29 +/- 0.02 litres/kg and a body ... -
Pharmacokinetics and tissue disposition of danofloxacin in sheep
(1998-03)The plasma pharmacokinetics of danofloxacin administered at 1.25 mg kg(-1) body weight by the intravenous and intramuscular routes were determined in sheep. Tissue distribution was also determined following administration ... -
Pharmacokinetics and tolerance of florfenicol in Equidae
(1996-05)Florfenicol was administered to horses and ponies at a dose rate of 22 mg/kg bwt by i.v., i.m. and oral routes. Following i.v. administration it had an elimination half-life of 1.8 +/- 0.9 h, a body clearance of 0.4 +/- ... -
Pharmacokinetics of a porcine insulin zinc suspension in diabetic dogs
(1997-10)Ten dogs with naturally occurring diabetes mellitus were injected with a highly purified porcine insulin zinc suspension at a dose according to their expected requirement. Plasma insulin and glucose concentrations were ... -
Pharmacokinetics of acetylcholinesterase reactivator K203 and consequent evaluation of low molecular weight antioxidants/markers of oxidative stress
(2012)Oxime K203 is a new compound designed to be used as an acetylcholinesterase reactivator for the treatment of intoxication following exposure to tabun and certain pesticides. After intramuscular administration of a therapeutic ... -
The pharmacokinetics of albendazole metabolites following administration of albendazole, albendazole sulfoxide and netobimin to one-month- and eight-month-old sheep
(1995-10)The principal metabolites detected in plasma of sheep following oral administration of albendazole (ABZ), albendazole sulfoxide (ABSO) and netobimin (NTB) each at 5.0 mg kg-1 body weight were ABSO and albendazole sulfone ...