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Now showing items 16712-16731 of 24202
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The pharmacokinetics of albendazole metabolites following administration of albendazole, albendazole sulfoxide and netobimin to one-month- and eight-month-old sheep
(1995-10)The principal metabolites detected in plasma of sheep following oral administration of albendazole (ABZ), albendazole sulfoxide (ABSO) and netobimin (NTB) each at 5.0 mg kg-1 body weight were ABSO and albendazole sulfone ... -
Pharmacokinetics of bacampicillin in equids
(1995)Bacampicillin hydrochloride is an ester prodrug that is hydrolyzed to ampicillin after its absorption from the gastrointestinal tract. It was administered intragastrically at a dose rate of 13.5 mg/kg of body weight to ... -
Pharmacokinetics of Bupropion and Its Metabolites in Haemodialysis Patients Who Smoke
(2004)To date, no study has investigated the effects of bupropion (BP) in renal-impaired humans. This study aims to identify the pharmacokinetics of BP and metabolites in haemodialysis patients who smoke, determine whether ... -
Pharmacokinetics of enrofloxacin and danofloxacin in plasma, inflammatory exudate, and bronchial secretions of calves following subcutaneous administration
(1999-08)Enrofloxacin (2.5 mg/kg of body weight) and danofloxacin (1.25 mg/kg) were administered subcutaneously to ruminating calves (n = 8) fitted with subcutaneous tissue cages. Concentrations of enrofloxacin, its metabolite ... -
Pharmacokinetics of fenbendazole in dogs
(1990)Fenbendazole was administered to dogs at a dose rate of 20 mg/kg body weight on a single occasion in gelatin capsules, on 5 consecutive days in feed, and on a single occasion as an alginate suspension. It was also administered ... -
The pharmacokinetics of flunixin meglumine in the sheep
(1993-06)Flunixin meglumine was administered intravenously and intramuscularly in sheep and the pharmacokinetics of the drug studied. Plasma concentrations of flunixin were measured by high performance liquid chromatography. The ... -
Pharmacokinetics of halofuginone in cattle
(1989-11-01)The pharmacokinetics of the antitheilerial drug halofuginone were evaluated in healthy calves following oral administration, at a dose of 1·2 mg/kg body weight, repeated after 48 h. The maximum plasma concentration after ... -
Pharmacokinetics of niclofolan in desert sheep
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Pharmacokinetics of topical products
(2012-06)Pharmacokinetics is the study of changes in drug concentrations in the body with time. It is commonly considered in four main phases: absorption, distribution, metabolism and excretion. Following topical administration, ... -
Pharmacokinetics, tolerance and serum thromboxane inhibition of carprofen in the dog
(1990)The non-steroidal anti-inflammatory drug (NSAID) carprofen was administered to dogs as a mixed-micelle solution at a dose rate of 0–7 mg/kg intravenously, as a palatable paste at a dose rate of 0–7 mg/kg orally, and as an ... -
Pharmacologic Profile of OC000459, a Potent, Selective, and Orally Active D Prostanoid Receptor 2 Antagonist That Inhibits Mast Cell-Dependent Activation of T Helper 2 Lymphocytes and Eosinophils
(2012-02)D prostanoid receptor 2 (DP2) [also known as chemoattractant receptor-homologous molecule expressed on T helper 2 (Th2) cells (CRTH2)] is selectively expressed by Th2 lymphocytes, eosinophils, and basophils and mediates ... -
Pharmacological Analysis of Cannabinoid Receptor Activity in Isolated Nerve-Smooth Muscle and Epithelial Preparations
(2007-12-14)This study was directed at characterising the cannabinoid receptor activity modulating the electrical field stimulation (EFS) evoked contractions of the rat isolated ileum myenteric plexus longitudinal muscle (MPLM) ... -
Pharmacological and psychotherapeutic interventions for management of obsessive-compulsive disorder in adults: a systematic review and network meta-analysis
(2016-08-01)Background Several interventions are available for management of obsessive-compulsive disorder in adults, but few studies have compared their relative efficacy in a single analysis. We aimed to simultaneously compare all ... -
Pharmacological approaches towards rationalizing the use of endoparasitic drugs in small animals
(2006)Parasitic diseases are an important health concern to small animal veterinarians worldwide, and their zoonotic potential is also of relevance to human medicine. The treatment and control of such conditions relies heavily ... -
Pharmacological assessment of netobimin as a potential anthelmintic for use in horses : Plasma disposition, faecal excretion and efficacy
(2009)This study aimed to determine the plasma disposition and faecal excretion of netobimin (NTB) and its respective metabolites as well as the efficacy against strongyles in horses following oral administration. Netobimin (10 ... -
Pharmacological characterization of cannabinoid receptor activity in the rat-isolated ileum myenteric plexus-longitudinal muscle preparation
(2010)Background and purpose: Cannabinoid effects on intestinal transit are commonly evaluated in rats. We characterized the cannabinoid receptors mediating the inhibitory effect of 5-(1,1-dimethylheptyl)-2-[5-hydroxy-2-(3-hyd ... -
Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS
(2020-11-04)Current literature addressing the pharmacological principles guiding glucocorticoid (GC) administration in ARDS is scant. This paucity of information may have led to the heterogeneity of treatment protocols and misinterpretation ...