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Now showing items 11394-11413 of 24089
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Inhibition in preschool children at risk of Developmental Language Disorder
(2019-06-04)While the precise nature of the deficits in Developmental Language Disorder (DLD) remains poorly defined, it has been hypothesized that executive function deficits may play a central role in the disorder. Research interest ... -
Inhibition in Preschool Children at Risk of Developmental Language Disorder
(2022-07-05)It has been hypothesised that executive function deficits, specifically inhibition difficulties, may play a central role in Developmental Language Disorder (DLD). The presented study compared the response inhibition abilities ... -
Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling
(2008-03-18)Background: Prostate cancer is a leading cause of male cancer specific mortality. When cure by radical prostatectomy is not possible the next line of prostate cancer treatment is androgen deprivation. However prolonged ... -
Inhibition of cellular proliferation by the genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone is mediated by DNA damage and activation of the ATR signalling pathway
(2007-12-15)The cellular actions of genistein, and its in vivo metabolites, are believed to mediate the decreased risk of breast cancer associated with high soy consumption. The genistein metabolite, 5,7,3',4'-tetrahydroxyisoflavone ... -
Inhibition of cyclo-oxygenase-2 expression by resveratrol derivatives from peanuts (Arachis hypogea L.)
(2004)A wide variety of plant phenolic substances possess anti-inflammatory and anti-carcinogenic activities, and for many of these substances inhibition of cyclo-oxygenase-2 (COX-2) appears to be an important mechanism of action ... -
Inhibition of inducible nitric oxide synthase expression by novel nonsteroidal anti-inflammatory drugs with nitroxy moiety
(1996)Effects of novel nitric oxide-releasing nonsteroidal anti-inflammatory compounds (NONSAIDs) on induction of nitric oxide (NO) synthase by bacterial lipopolysaccharide (LPS) were examined in a cultured murine macrophage ... -
Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo
(2015-08-25)Microvesicles shed from cells carry constituents of the cell cytoplasm, including, of importance in multidrug resistance to cancer chemotherapy, drugs that the tumor cell attempts to efflux. To see whether such drugs could ... -
Inhibition of ornithine decarboxylase potentiates nitric oxide production in LPS-activated J774 cells
(1998)We have examined whether modulation of the polyamine biosynthetic pathway, through inhibition by α-difluoromethylornithine (DFMO) of the rate limiting enzyme, ornithine decarboxylase (ODC), modulates NO synthesis in J774 ... -
Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols
(2007-10-19)The death of nigral neurons in Parkinson's disease is thought to involve the formation of the endogenous neurotoxin, 5-S-cysteinyl-dopamine. In the present study, we show that the polyphenols, (+)-catechin and caffeic acid, ... -
Inhibition of the glycaemic response by onion : a comparison between lactose-tolerant and lactose-intolerant adults
(2016-03-30)This pilot study compared inhibition of the glycaemic response to glucose by a dietary source of quercetin glucosides (onion) in lactose-tolerant adults (n = 12) and lactose-intolerant adults (n = 12). We hypothesised that ... -
Inhibition of thoughts and actions in obsessive-compulsive disorder: extending the endophenotype?
(2010)Background: Obsessive-compulsive disorder (OCD) has been associated with impairments in stop-signal inhibition, a measure of motor response suppression. The study used a novel paradigm to examine both thought suppression ... -
Inhibition or Treatment of Dyskinesia
(2006-08-24)Prevention or treatment of dyskinesia induced by L-dopa or dopamine agonist can be effected by use of a selective inhibitor of neuronal nitric oxide synthase -
Inhibition-Related Cortical Hypoconnectivity as a Candidate Vulnerability Marker for Obsessive-Compulsive Disorder
(2020-02)BACKGROUND: Obsessive-compulsive disorder (OCD) is a prevalent neuropsychiatric condition, with biological models implicating disruption of cortically mediated inhibitory control pathways, ordinarily serving to regulate ... -
Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates
(2004-02-23)Multidrug-resistance (MDR) occurs in many bacterial species and tumour cells. MDR functions by membrane proteins which export drugs from cells, resulting in a low ineffective concentration of the drug. We have shown by ... -
The inhibitory effect of 6-gingerol and cisplatin on ovarian cancer and antitumor activity: In silico, in vitro, and in vivo
(2023-03-03)Background: Epithelial ovarian cancer is very common in women and causes hundreds of deaths per year worldwide. Chemotherapy drugs including cisplatin have adverse effects on patients’ health. Complementary treatments and ...