Browsing by Title
Now showing items 16646-16665 of 24095
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Pharmacokinetics of niclofolan in desert sheep
(1990-06) -
Pharmacokinetics of topical products
(2012-06)Pharmacokinetics is the study of changes in drug concentrations in the body with time. It is commonly considered in four main phases: absorption, distribution, metabolism and excretion. Following topical administration, ... -
Pharmacokinetics, tolerance and serum thromboxane inhibition of carprofen in the dog
(1990)The non-steroidal anti-inflammatory drug (NSAID) carprofen was administered to dogs as a mixed-micelle solution at a dose rate of 0–7 mg/kg intravenously, as a palatable paste at a dose rate of 0–7 mg/kg orally, and as an ... -
Pharmacologic Profile of OC000459, a Potent, Selective, and Orally Active D Prostanoid Receptor 2 Antagonist That Inhibits Mast Cell-Dependent Activation of T Helper 2 Lymphocytes and Eosinophils
(2012-02)D prostanoid receptor 2 (DP2) [also known as chemoattractant receptor-homologous molecule expressed on T helper 2 (Th2) cells (CRTH2)] is selectively expressed by Th2 lymphocytes, eosinophils, and basophils and mediates ... -
Pharmacological Analysis of Cannabinoid Receptor Activity in Isolated Nerve-Smooth Muscle and Epithelial Preparations
(2007-12-14)This study was directed at characterising the cannabinoid receptor activity modulating the electrical field stimulation (EFS) evoked contractions of the rat isolated ileum myenteric plexus longitudinal muscle (MPLM) ... -
Pharmacological and psychotherapeutic interventions for management of obsessive-compulsive disorder in adults: a systematic review and network meta-analysis
(2016-08-01)Background Several interventions are available for management of obsessive-compulsive disorder in adults, but few studies have compared their relative efficacy in a single analysis. We aimed to simultaneously compare all ... -
Pharmacological approaches towards rationalizing the use of endoparasitic drugs in small animals
(2006)Parasitic diseases are an important health concern to small animal veterinarians worldwide, and their zoonotic potential is also of relevance to human medicine. The treatment and control of such conditions relies heavily ... -
Pharmacological assessment of netobimin as a potential anthelmintic for use in horses : Plasma disposition, faecal excretion and efficacy
(2009)This study aimed to determine the plasma disposition and faecal excretion of netobimin (NTB) and its respective metabolites as well as the efficacy against strongyles in horses following oral administration. Netobimin (10 ... -
Pharmacological characterization of cannabinoid receptor activity in the rat-isolated ileum myenteric plexus-longitudinal muscle preparation
(2010)Background and purpose: Cannabinoid effects on intestinal transit are commonly evaluated in rats. We characterized the cannabinoid receptors mediating the inhibitory effect of 5-(1,1-dimethylheptyl)-2-[5-hydroxy-2-(3-hyd ... -
Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS
(2020-11-04)Current literature addressing the pharmacological principles guiding glucocorticoid (GC) administration in ARDS is scant. This paucity of information may have led to the heterogeneity of treatment protocols and misinterpretation ... -
Pharmacology and therapeutics of non-steroidal anti-inflammatory drugs in the dog and cat 2 : Individual agents
(1991)The general pharmacology of the non-steroidal anti-inflammatory drugs (NSAIDs) used in dogs and cats has been described in part 1 of this review (Lees and others 1991). This paper outlines the properties of the individual ... -
Pharmacology and therapeutics of nonsteroidal antiinflammatory drugs in the dog and cat 1 : General pharmacology
(1991)The inflammatory process is described with particular reference to the cardinal signs, the microcir-culatory changes and the mediators and modulators of inflammation. Mediators and modulars comprise targets for therapeutic ... -
Pharmacology of airways and vessels in lung slices in situ : Role of endogenous dilator hormones
(2006-08-21)Small airway and vessels play a critical role in chronic airway and pulmonary vascular diseases, but their pharmacology has not been well characterised. We have studied airway and vascular responses in rat lung slices and ... -
The pharmacology of flukicidal drugs
(1991-07) -
Pharmacotherapy for obsessive-compulsive disorder
(2011-11-01)We present a narrative review of evidence-based treatment for obsessive-compulsive disorder (OCD), covering first-line pharmacological treatment, augmentation strategies, approaches for treatment-refractory OCD and the ... -
Pharmacovigilance Signals of the Opioid Epidemic over 10 Years: Data Mining Methods in the Analysis of Pharmacovigilance Datasets Collecting Adverse Drug Reactions (ADRs) Reported to EudraVigilance (EV) and the FDA Adverse Event Reporting System (FAERS)
(2022-05-27)In the past twenty years, the consumption of opioid medications has reached significant proportions, leading to a rise in drug misuse and abuse and increased opioid dependence and related fatalities. Thus, the purpose of ... -
Pharmacy consultation outcomes during a lung cancer awareness campaign
(2015-09-29)Lung cancer remains a condition that is frequently diagnosed too late for optimum prognosis [1]. Several factors seem to contribute to this, but there is good evidence that response to potential symptoms of lung cancer and ... -
Pharmacy services to UK emergency departments : a descriptive study
(2010)Objective To describe current hospital pharmacy services and facilities provided to United Kingdom Emergency Departments (EDs), identify potential roles for pharmacy technicians and possible benefits pharmacists may bring ...