Targeting glycolysis : a fragment based approach towards bifunctional inhibitors of hLDH-5
Author
Moorhouse, Adam D.
Spiteri, Christian
Sharma, Pallavi
Zloh, Mire
Moses, John E.
Attention
2299/10548
Abstract
hLDH-5 has emerged as a promising target for anti-glycolytic cancer chemotherapy. Here we report a first generation of bifunctional inhibitors, which show promising activity against hLDH-5.