NK1 antagonists based on seven membered lactam scaffolds
Author
Elliott, J. M.
Carlson, E. J.
Chcchi, G. G.
Dirat, O.
Dominguez, M.
Gerhard, U.
Jelley, R.
Jones, A. B.
Kurtz, M. M.
Tsao, K. I.
Wheeldon, A.
Attention
2299/12386
Abstract
A new class of high affinity hNK(1)R antagonists based on seven-membered ring cores has been identified. This series, with relatively simple, compact structures, includes compounds with high affinity, good selectivity, and promising in vivo properties. (c) 2006 Elsevier Ltd. All rights reserved.