Transiently supersaturated solutions from the dissolution of amorphous powders for topical drug delivery
Author
Palmer, I. A.
Jones, S. A.
Murnane, D.
Traynor, M.J.
Moss, Gary
Brown, Marc
Attention
2299/15239
Abstract
The aim of this study was to prepare amorphous forms of clotrimazole to determine whether increasing the rate and extent of dissolution of clotrimazole would result in supersaturated solutions capable of increasing the bioavailability and subsequent therapeutic activity of clotrimazole