dc.contributor.author | Li, Longfei | |
dc.contributor.author | Chen, Lin | |
dc.contributor.author | Zhang, Huan | |
dc.contributor.author | Yang, Yongzhen | |
dc.contributor.author | Liu, Xuguang | |
dc.contributor.author | Chen, Yong | |
dc.date.accessioned | 2016-04-27T11:09:33Z | |
dc.date.available | 2016-04-27T11:09:33Z | |
dc.date.issued | 2016-04-01 | |
dc.identifier.citation | Li , L , Chen , L , Zhang , H , Yang , Y , Liu , X & Chen , Y 2016 , ' Temperature and magnetism bi-responsive molecularly imprinted polymers: Preparation, adsorption mechanism and properties as drug delivery system for sustained release of 5-fluorouracil ' , Materials Science and Engineering C , vol. 61 , pp. 158-168 . https://doi.org/10.1016/j.msec.2015.12.027 | |
dc.identifier.issn | 0928-4931 | |
dc.identifier.uri | http://hdl.handle.net/2299/17141 | |
dc.description | This document is the Accepted Manuscript version of the following article: Longfei Li, Lin Chen, Huan Zhang, Yongshen Yang, Xuguang Liu, and Yongkang Chen, ‘Temperature and magnetism bi-responsive molecularly imprinted polymers: Preparation, adsorption mechanism and properties as drug delivery system for sustained release of 5-fluorouracil’, Materials Science and Engineering: C, Vol. 61: 158-168, April 2016, made available under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License CC BY NC-ND 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |
dc.description.abstract | Temperature and magnetism bi-responsive molecularly imprinted polymers (TMMIPs) based on Fe3O4-encapsulating carbon nanospheres were prepared by free radical polymerization, and applied to selective adsorption and controlled release of 5-fluorouracil (5-FU) from an aqueous solution. Characterization results show that the as-synthesized TMMIPs have an average diameter of about 150 nm with a typical core–shell structure, and the thickness of the coating layer is approximately 50 nm. TMMIPs also displayed obvious magnetic properties and thermo-sensitivity. The adsorption results show that the prepared TMMIPs exhibit good adsorption capacity (up to 96.53 mg/g at 25 °C) and recognition towards 5-FU. The studies on 5-FU loading and release in vitro suggest that the release rate increases with increasing temperature. Meanwhile, adsorption mechanisms were explored by using a computational analysis to simulate the imprinted site towards 5-FU. The interaction energy between the imprinted site and 5-FU is − 112.24 kJ/mol, originating from a hydrogen bond, Van der Waals forces and a hydrophobic interaction between functional groups located on 5-FU and a NIPAM monomer. The electrostatic potential charges and population analysis results suggest that the imprinted site of 5-FU can be introduced on the surface of TMMIPs, confirming their selective adsorption behavior for 5-FU. | en |
dc.format.extent | 11 | |
dc.format.extent | 1647786 | |
dc.language.iso | eng | |
dc.relation.ispartof | Materials Science and Engineering C | |
dc.subject | Molecular imprinting technique | |
dc.subject | Temperature-sensitivity | |
dc.subject | Magnetism | |
dc.subject | Drug delivery system | |
dc.subject | Simulate | |
dc.subject | Imprinted site | |
dc.title | Temperature and magnetism bi-responsive molecularly imprinted polymers: Preparation, adsorption mechanism and properties as drug delivery system for sustained release of 5-fluorouracil | en |
dc.contributor.institution | School of Engineering and Technology | |
dc.contributor.institution | Centre for Engineering Research | |
dc.contributor.institution | Sustainable Energy Technologies | |
dc.description.status | Peer reviewed | |
dc.date.embargoedUntil | 2016-12-16 | |
rioxxterms.versionofrecord | 10.1016/j.msec.2015.12.027 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |