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Decoding odor quality and intensity in the Drosophila brain

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contributor authorStrutz, Antonia
contributor authorSoelter, Jan
contributor authorBaschwitz, Amelie
contributor authorFarhan, Abu
contributor authorGrabe, Veit
contributor authorRybak, Jürgen
contributor authorKnaden, Markus
contributor authorSchmuker, Michael
contributor authorHansson, Bill S
contributor authorSachse, Silke
date accessioned2017-09-13T15:58:00Z
date available2017-09-13T15:58:00Z
date issued2014-12-16
identifier citationStrutz , A , Soelter , J , Baschwitz , A , Farhan , A , Grabe , V , Rybak , J , Knaden , M , Schmuker , M , Hansson , B S & Sachse , S 2014 , ' Decoding odor quality and intensity in the Drosophila brain ' eLife , vol 3 . DOI: 10.7554/eLife.04147en
identifier issn2050-084X
identifier otherPURE: 10469230
identifier otherPURE UUID: f8eeade1-477b-40f5-bda7-4f816262f362
identifier otherPubMed: 25512254
identifier urihttp://hdl.handle.net/2299/19379
descriptionCopyright © 2014 Strutz et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.en
description abstractTo internally reflect the sensory environment, animals create neural maps encoding the external stimulus space. From that primary neural code relevant information has to be extracted for accurate navigation. We analyzed how different odor features such as hedonic valence and intensity are functionally integrated in the lateral horn (LH) of the vinegar fly, Drosophila melanogaster. We characterized an olfactory-processing pathway, comprised of inhibitory projection neurons (iPNs) that target the LH exclusively, at morphological, functional and behavioral levels. We demonstrate that iPNs are subdivided into two morphological groups encoding positive hedonic valence or intensity information and conveying these features into separate domains in the LH. Silencing iPNs severely diminished flies' attraction behavior. Moreover, functional imaging disclosed a LH region tuned to repulsive odors comprised exclusively of third-order neurons. We provide evidence for a feature-based map in the LH, and elucidate its role as the center for integrating behaviorally relevant olfactory information.en
language isoeng
relation ispartofeLifeen
rightsen
subjectAnimalsen
subjectBrainen
subjectCalcium Signalingen
subjectDendritesen
subjectDrosophila melanogasteren
subjectNeural Inhibitionen
subjectOdorsen
subjectOlfactory Pathwaysen
subjectgamma-Aminobutyric Aciden
titleDecoding odor quality and intensity in the Drosophila brainen
typeArticleen
contributor institutionSchool of Computer Scienceen
identifier doihttp://dx.doi.org/10.7554/eLife.04147
description versionpublishersversionen
description statusPeer revieweden


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