dc.contributor.author | Kopsch, Thomas | |
dc.contributor.author | Murnane, Darragh | |
dc.contributor.author | Symons, Digby | |
dc.date.accessioned | 2017-11-23T13:11:25Z | |
dc.date.available | 2017-11-23T13:11:25Z | |
dc.date.issued | 2016-11-01 | |
dc.identifier.citation | Kopsch , T , Murnane , D & Symons , D 2016 , ' Optimizing the Entrainment Geometry of a Dry Powder Inhaler : Methodology and Preliminary Results ' , Pharmaceutical Research , vol. 33 , no. 11 , pp. 2668-2679 . https://doi.org/10.1007/s11095-016-1992-3 | |
dc.identifier.issn | 0724-8741 | |
dc.identifier.uri | http://hdl.handle.net/2299/19550 | |
dc.description | This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |
dc.description.abstract | Purpose: For passive dry powder inhalers (DPIs) entrainment and emission of the aerosolized drug dose depends strongly on device geometry and the patient’s inhalation manoeuvre. We propose a computational method for optimizing the entrainment part of a DPI. The approach assumes that the pulmonary delivery location of aerosol can be determined by the timing of dose emission into the tidal airstream. Methods: An optimization algorithm was used to iteratively perform computational fluid dynamic (CFD) simulations of the drug emission of a DPI. The algorithm seeks to improve performance by changing the device geometry. Objectives were to achieve drug emission that was: A) independent of inhalation manoeuvre; B) similar to a target profile. The simulations used complete inhalation flow-rate profiles generated dependent on the device resistance. The CFD solver was OpenFOAM with drug/air flow simulated by the Eulerian-Eulerian method. Results: To demonstrate the method, a 2D geometry was optimized for inhalation independence (comparing two breath profiles) and an early-bolus delivery. Entrainment was both shear-driven and gas-assisted. Optimization for a delay in the bolus delivery was not possible with the chosen geometry. Conclusions: Computational optimization of a DPI geometry for most similar drug delivery has been accomplished for an example entrainment geometry. | en |
dc.format.extent | 12 | |
dc.format.extent | 2181917 | |
dc.language.iso | eng | |
dc.relation.ispartof | Pharmaceutical Research | |
dc.subject | boundary-condition | |
dc.subject | cost-function | |
dc.subject | DPI | |
dc.subject | entrainment | |
dc.subject | optimization | |
dc.subject | Biotechnology | |
dc.subject | Molecular Medicine | |
dc.subject | Pharmacology | |
dc.subject | Pharmaceutical Science | |
dc.subject | Organic Chemistry | |
dc.subject | Pharmacology (medical) | |
dc.title | Optimizing the Entrainment Geometry of a Dry Powder Inhaler : Methodology and Preliminary Results | en |
dc.contributor.institution | Department of Pharmacy | |
dc.contributor.institution | University of Hertfordshire | |
dc.description.status | Peer reviewed | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=84978100601&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1007/s11095-016-1992-3 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |