Evaluation of the ability of a novel miconazole formulation to penetrate nail by using three in vitro nail models
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Author
Christensen, Luisa
Turner, Rob
Weaver, Sean
Caserta, Francesco
Long, Lisa
Ghannoum, Mahmoud
Brown, Marc
Attention
2299/19716
Abstract
In an effort to increase the efficacy of topical medications for treating onychomycosis, several new nail penetration enhancers were recently developed. In this study, the ability of 10% (wt/wt) miconazole nitrate combined with a penetration enhancer formulation to permeate the nail is demonstrated by the use of a selection of in vitro nail penetration assays. These assays included the bovine hoof, TurChub zone of inhibition, and infected-nail models.