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Intensive care in patients with lung cancer : a multinational study

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contributor authorSoares, M
contributor authorToffart, A-C
contributor authorTimsit, J-F
contributor authorBurghi, G
contributor authorIrrazábal, C
contributor authorPattison, N
contributor authorTobar, E
contributor authorAlmeida, B F C
contributor authorSilva, U V A
contributor authorAzevedo, L C P
contributor authorRabbat, A
contributor authorLamer, C
contributor authorParrot, A
contributor authorSouza-Dantas, V C
contributor authorWallet, F
contributor authorBlot, F
contributor authorBourdin, G
contributor authorPiras, C
contributor authorDelemazure, J
contributor authorDurand, M
contributor authorTejera, D
contributor authorSalluh, J I F
contributor authorAzoulay, E
contributor authorLung Cancer in Critical Care (LUCCA) Study Investigators
date accessioned2018-02-12T18:07:19Z
date available2018-02-12T18:07:19Z
date issued2014-09-01
identifier citationSoares , M , Toffart , A-C , Timsit , J-F , Burghi , G , Irrazábal , C , Pattison , N , Tobar , E , Almeida , B F C , Silva , U V A , Azevedo , L C P , Rabbat , A , Lamer , C , Parrot , A , Souza-Dantas , V C , Wallet , F , Blot , F , Bourdin , G , Piras , C , Delemazure , J , Durand , M , Tejera , D , Salluh , J I F , Azoulay , E & Lung Cancer in Critical Care (LUCCA) Study Investigators 2014 , ' Intensive care in patients with lung cancer : a multinational study ' Annals of Oncology , vol 25 , no. 9 , pp. 1829-35 . DOI: 10.1093/annonc/mdu234en
identifier issn0923-7534
identifier otherPURE: 12903525
identifier otherPURE UUID: 550b6e7a-42d9-44e5-a3b6-ea4993c9c487
identifier otherPubMed: 24950981
identifier otherScopus: 84904821961
identifier urihttp://hdl.handle.net/2299/19772
descriptionThis is a pre-copyedited, author-produced version of an article accepted for publication in Annals of Oncology following peer review. The version of record M. Soares, et al, 'Intensive care in patients with lung cancer: a multinational study', Annals of Oncology, Vol. 25 (9): 1829-1835, September 2014, is available online at https://doi.org/10.1093/annonc/mdu234.en
description abstractBACKGROUND: Detailed information about lung cancer patients requiring admission to intensive care units (ICUs) is mostly restricted to single-center studies. Our aim was to evaluate the clinical characteristics and outcomes of lung cancer patients admitted to ICUs. PATIENTS AND METHODS: Prospective multicenter study in 449 patients with lung cancer (small cell, n = 55; non-small cell, n = 394) admitted to 22 ICUs in six countries in Europe and South America during 2011. Multivariate Cox proportional hazards frailty models were built to identify characteristics associated with 30-day and 6-month mortality. RESULTS: Most of the patients (71%) had newly diagnosed cancer. Cancer-related complications occurred in 56% of patients; the most common was tumoral airway involvement (26%). Ventilatory support was required in 53% of patients. Overall hospital, 30-day, and 6-month mortality rates were 39%, 41%, and 55%, respectively. After adjustment for type of admission and early treatment-limitation decisions, determinants of mortality were organ dysfunction severity, poor performance status (PS), recurrent/progressive cancer, and cancer-related complications. Mortality rates were far lower in the patient subset with nonrecurrent/progressive cancer and a good PS, even those with sepsis, multiple organ dysfunctions, and need for ventilatory support. Mortality was also lower in high-volume centers. Poor PS predicted failure to receive the initially planned cancer treatment after hospital discharge. CONCLUSIONS: ICU admission was associated with meaningful survival in lung cancer patients with good PS and non-recurrent/progressive disease. Conversely, mortality rates were very high in patients not fit for anticancer treatment and poor PS. In this subgroup, palliative care may be the best option.en
format extent7en
language isoeng
relation ispartofAnnals of Oncologyen
rightsen
subjectCarcinoma, Non-Small-Cell Lungen
subjectCohort Studiesen
subjectCritical Careen
subjectFemaleen
subjectHumansen
subjectLungen
subjectLung Neoplasmsen
subjectMaleen
subjectMiddle Ageden
subjectProspective Studiesen
subjectSeverity of Illness Indexen
subjectTreatment Outcomeen
subjectJournal Articleen
subjectMulticenter Studyen
subjectObservational Studyen
subjectResearch Support, Non-U.S. Gov'ten
titleIntensive care in patients with lung cancer : a multinational studyen
typeArticleen
contributor institutionDepartment of Adult Nursing and Primary Careen
contributor institutionSchool of Health and Social Worken
identifier doihttps://doi.org/10.1093/annonc/mdu234
description versionauthorsversionen
description statusPeer revieweden


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