dc.contributor.author | Dimov, Nikolay | |
dc.contributor.author | Kastner, Elisabeth | |
dc.contributor.author | Hussain, Maryam | |
dc.contributor.author | Perrie, Yvonne | |
dc.contributor.author | Szita, Nicolas | |
dc.date.accessioned | 2018-03-06T18:06:56Z | |
dc.date.available | 2018-03-06T18:06:56Z | |
dc.date.issued | 2017-09-21 | |
dc.identifier.citation | Dimov , N , Kastner , E , Hussain , M , Perrie , Y & Szita , N 2017 , ' Formation and purification of tailored liposomes for drug delivery using a module-based micro continuous-flow system ' , Scientific Reports , vol. 7 , 12045 . https://doi.org/10.1038/s41598-017-11533-1 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.other | ORCID: /0000-0002-2873-1505/work/63687433 | |
dc.identifier.uri | http://hdl.handle.net/2299/19870 | |
dc.description | This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License CC BY 4.0 http://creativecommons.org/licenses/by/4.0/ , which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |
dc.description.abstract | Liposomes are lipid based bilayer vesicles that can encapsulate, deliver and release low-soluble drugs and small molecules to a specific target site in the body. They are currently exploited in several nanomedicine formulations. However, their development and application is still limited by expensive and time-consuming process development and production methods. Therefore, to exploit these systems more effectively and support the rapid translation of new liposomal nanomedicines from bench to bedside, new cost-effective and scalable production methods are needed. We present a continuous process flow system for the preparation, modification and purification of liposomes which offers lab-on-chip scale production. The system was evaluated for a range of small vesicles (below 300 nm) varying in lipid composition, size and charge; it offers effective and rapid nanomedicine purification with high lipid recovery (> 98%) combined with effective removal of non-entrapped drug (propofol >95% reduction of non-entrapped drug present) or protein (ovalbumin >90% reduction of OVA present) and organic solvent (ethanol >95% reduction) in less than 4 minutes. The key advantages of using this bench-top, rapid, process development tool are the flexible operating conditions, interchangeable membranes and scalable high-throughput yields, thereby offering simultaneous manufacturing and purification of nanoparticles with tailored surface attributes. | en |
dc.format.extent | 2806299 | |
dc.language.iso | eng | |
dc.relation.ispartof | Scientific Reports | |
dc.subject | General | |
dc.title | Formation and purification of tailored liposomes for drug delivery using a module-based micro continuous-flow system | en |
dc.contributor.institution | School of Physics, Engineering & Computer Science | |
dc.description.status | Peer reviewed | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85029832199&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1038/s41598-017-11533-1 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |