Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae
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Author
Singh, Kumar Saurabh
Cordeiro, Erick M. G.
Troczka, Bartlomiej J.
Pym, Adam
Mackisack, Joanna
Mathers, Thomas C.
Duarte, Ana
Legeai, Fabrice
Robin, Stéphanie
Bielza, Pablo
Burrack, Hannah J.
Charaabi, Kamel
Denholm, Ian
Figueroa, Christian C.
ffrench-Constant, Richard H.
Jander, Georg
Margaritopoulos, John T.
Mazzoni, Emanuele
Nauen, Ralf
Ramírez, Claudio C.
Ren, Guangwei
Stepanyan, Ilona
Umina, Paul A.
Voronova, Nina V.
Vontas, John
Williamson, Martin S.
Wilson, Alex C. C.
Xi-Wu, Gao
Youn, Young-Nam
Zimmer, Christoph T.
Simon, Jean-Christophe
Hayward, Alex
Bass, Chris
Attention
2299/25014
Abstract
Abstract: The aphid Myzus persicae is a destructive agricultural pest that displays an exceptional ability to develop resistance to both natural and synthetic insecticides. To investigate the evolution of resistance in this species we generated a chromosome-scale genome assembly and living panel of >110 fully sequenced globally sampled clonal lines. Our analyses reveal a remarkable diversity of resistance mutations segregating in global populations of M. persicae. We show that the emergence and spread of these mechanisms is influenced by host–plant associations, uncovering the widespread co‐option of a host-plant adaptation that also offers resistance against synthetic insecticides. We identify both the repeated evolution of independent resistance mutations at the same locus, and multiple instances of the evolution of novel resistance mechanisms against key insecticides. Our findings provide fundamental insights into the genomic responses of global insect populations to strong selective forces, and hold practical relevance for the control of pests and parasites.