The East Asian Paradox : An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease
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Author
Kim, Hyun Kuk
Tantry, Udaya S.
Smith, Sidney C.
Jeong, Myung Ho
Park, Seung Jung
Kim, Moo Hyun
Lim, Do Sun
Shin, Eun Seok
Park, Duk Woo
Huo, Yong
Chen, Shao Liang
Bo, Zheng
Goto, Shinya
Kimura, Takeshi
Yasuda, Satoshi
Chen, Wen Jone
Chan, Mark
Aradi, Daniel
Geisler, Tobias
Gorog, Diana A.
Sibbing, Dirk
Lip, Gregory Y.H.
Angiolillo, Dominick J.
Gurbel, Paul A.
Jeong, Young Hoon
Attention
2299/25230
Abstract
East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y 12receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk-benefit trade-off in East Asians has been a topic of emerging interest. In this article, we propose updated evidence and future directions of antithrombotic treatment in East Asian patients.