dc.contributor.author | Zhao, Hongda | |
dc.contributor.author | Chan, Vinson Wai-Shun | |
dc.contributor.author | Castellani, Daniele | |
dc.contributor.author | Chan, Erica On-Ting | |
dc.contributor.author | Ong, William Lay Keat | |
dc.contributor.author | Peng, Qiang | |
dc.contributor.author | Moschini, Marco | |
dc.contributor.author | Krajewski, Wojciech | |
dc.contributor.author | Pradere, Benjamin | |
dc.contributor.author | Ng, Chi-Fai | |
dc.contributor.author | Enikeev, Dmitry | |
dc.contributor.author | Vasdev, Nikhil | |
dc.contributor.author | Ekin, Gokhan | |
dc.contributor.author | Sousa, Alejandro | |
dc.contributor.author | Leon, Juan | |
dc.contributor.author | Guerrero-Ramos, Felix | |
dc.contributor.author | Tan, Wei-Shen | |
dc.contributor.author | Kelly, John | |
dc.contributor.author | Shariat, Shahrokh F. | |
dc.contributor.author | Witjes, J. Alfred | |
dc.contributor.author | Teoh, Jeremy Yuen-Chun | |
dc.date.accessioned | 2021-12-08T11:00:02Z | |
dc.date.available | 2021-12-08T11:00:02Z | |
dc.date.issued | 2021-11-23 | |
dc.identifier.citation | Zhao , H , Chan , V W-S , Castellani , D , Chan , E O-T , Ong , W L K , Peng , Q , Moschini , M , Krajewski , W , Pradere , B , Ng , C-F , Enikeev , D , Vasdev , N , Ekin , G , Sousa , A , Leon , J , Guerrero-Ramos , F , Tan , W-S , Kelly , J , Shariat , S F , Witjes , J A & Teoh , J Y-C 2021 , ' Intravesical Chemohyperthermia vs. Bacillus Calmette-Guerin Instillation for Intermediate- and High-Risk Non-muscle Invasive Bladder Cancer: A Systematic Review and Meta-Analysis ' , Frontiers in Surgery , vol. 8 , 775527 . https://doi.org/10.3389/fsurg.2021.775527 | |
dc.identifier.issn | 2296-875X | |
dc.identifier.other | Jisc: 43d6c89595ca4acfb41f9abe44af99f4 | |
dc.identifier.uri | http://hdl.handle.net/2299/25237 | |
dc.description | © 2021 Zhao, Chan, Castellani, Chan, Ong, Peng, Moschini, Krajewski, Pradere, Ng, Enikeev, Vasdev, Ekin, Sousa, Leon, Guerrero-Ramos, Tan, Kelly, Shariat, Witjes and Teoh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). https://creativecommons.org/licenses/by/4.0/ | |
dc.description.abstract | Background: The efficacy of intravesical chemotherapy maintenance for patients with non-muscle invasive bladder cancer (NMIBC) is inferior compared to intravesical bacillus Calmette–Guerin (BCG). How intravesical chemohyperthermia (CHT) compares with BCG is under investigation. Objective: To compare the oncological outcomes and safety profile between intravesical CHT and BCG treatment for intermediate- and high-risk NMIBC. Methods: We performed a systematic review and meta-analysis of clinical studies comparing CHT with BCG for intermediate- and high-risk NMIBC patients. A comprehensive literature search on OVID MEDLINE, EMBASE, and Cochrane Library was conducted. Risk of bias was assessed by the Cochrane RoB tool and ROBINS-I. Certainty of evidence was rated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. Results: A total of 2,375 articles were identified and five studies were finally included. Among them, four randomised trials comprising 327 patients (CHT group: 156 patients; BCG group: 171 patients) were included in the meta-analysis. There were no significant differences in the 24–36 months recurrence rates (CHT: 29.5%, BCG: 37.4%; RR: 0.83, 95% CI 0.61–1.13; moderate certainty of evidence) and the 24–36 months progression rates (CHT: 4.4%, BCG: 7.6%, RR = 0.62, 95% CI 0.26–1.49; low certainty of evidence). There were also no significant differences in grade 1–2 adverse events (CHT group: 59.9%, BCG group 54.5%; RR = 1.10, 95% CI 0.93–1.30; moderate certainty of evidence) and grade 3 or above adverse events (CHT group: 23.2%, BCG group 22.5%; RR = 0.99, 95% CI 0.69–1.43; low certainty of evidence). Conclusions: Intravesical CHT had equivalent oncological outcomes and similar safety profile when compared to BCG maintenance therapy for patients with intermediate- and high-risk NMIBC. CHT is a possible alternative treatment in the times of BCG shortage. | en |
dc.format.extent | 12 | |
dc.format.extent | 1455414 | |
dc.language.iso | eng | |
dc.relation.ispartof | Frontiers in Surgery | |
dc.subject | Surgery | |
dc.subject | bladder cancer | |
dc.subject | TURBT (trans-urethral resection of bladder tumour) | |
dc.subject | BCG–Bacillus Calmette-Guérin vaccine | |
dc.subject | chemohyperthermia | |
dc.subject | meta-analysis | |
dc.title | Intravesical Chemohyperthermia vs. Bacillus Calmette-Guerin Instillation for Intermediate- and High-Risk Non-muscle Invasive Bladder Cancer: A Systematic Review and Meta-Analysis | en |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Extracellular Vesicle Research Unit | |
dc.contributor.institution | Basic and Clinical Science Unit | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Centre for Engineering Research | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.3389/fsurg.2021.775527 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |