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dc.contributor.authorSalari, Zohreh
dc.contributor.authorKhosravi, Ahmad
dc.contributor.authorPourkhandani, Elham
dc.contributor.authorMolaakbari, Elaheh
dc.contributor.authorSalarkia, Ehsan
dc.contributor.authorKeyhani, Alireza
dc.contributor.authorSharifi, Iraj
dc.contributor.authorTavakkoli, Hadi
dc.contributor.authorSohbati, Samira
dc.contributor.authorDabiri, Shahriar
dc.contributor.authorRen, Guogang
dc.contributor.authorShafie’ei, Mohammad
dc.date.accessioned2023-03-21T16:30:01Z
dc.date.available2023-03-21T16:30:01Z
dc.date.issued2023-03-03
dc.identifier.citationSalari , Z , Khosravi , A , Pourkhandani , E , Molaakbari , E , Salarkia , E , Keyhani , A , Sharifi , I , Tavakkoli , H , Sohbati , S , Dabiri , S , Ren , G & Shafie’ei , M 2023 , ' The inhibitory effect of 6-gingerol and cisplatin on ovarian cancer and antitumor activity: In silico, in vitro, and in vivo ' , Frontiers in Oncology , vol. 13 , 1098429 , pp. 1-17 . https://doi.org/10.3389/fonc.2023.1098429
dc.identifier.otherJisc: 964066
dc.identifier.otherORCID: /0000-0001-8865-1526/work/131544766
dc.identifier.otherPubMedCentral: PMC10020515
dc.identifier.urihttp://hdl.handle.net/2299/26130
dc.description© 2023 Salari, Khosravi, Pourkhandani, Molaakbari, Salarkia, Keyhani, Sharifi, Tavakkoli, Sohbati, Dabiri, Ren and Shafie’ei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). https://creativecommons.org/licenses/by/4.0/
dc.description.abstractBackground: Epithelial ovarian cancer is very common in women and causes hundreds of deaths per year worldwide. Chemotherapy drugs including cisplatin have adverse effects on patients’ health. Complementary treatments and the use of herbal medicines can help improve the performance of medicine. 6-Gingerol is the major pharmacologically active component of ginger. In this study, we compared the effects of 6-gingerol, cisplatin, and their combination in apoptotic and angiogenetic activities in silico, in test tubes, and in in vivo assays against two ovarian cancer cell lines: OVCAR-3 and human umbilical vein endothelial cells (HUVECs). Methods: The drug-treated cell lines were evaluated for their cytotoxicity, cell cycle, and apoptotic and angiogenetic gene expression changes. Results: The proportion of apoptosis treated by 6-gingerol coupled with cisplatin was significantly high. In the evaluation of the cell cycle, the combination therapy also showed a significant promotion of a higher extent of the S sequence. The expression of p53 level, Caspase-8, Bax, and Apaf1 genes was amplified again with combination therapy. Conversely, in both cell lines, the cumulative drug concentrations reduced the expression of VEGF, FLT1, KDR, and Bcl-2 genes. Similarly, in the control group, combination treatment significantly decreased the expression of VEGF, FLT1, KDR, and Bcl-2 genes in comparison to cisplatin alone. Conclusions: The findings of the present study demonstrated that the cisplatin and 6-gingerol combination is more effective in inducing apoptosis and suppressing the angiogenesis of ovarian cancer cells than using each drug alone.en
dc.format.extent17
dc.format.extent12801926
dc.language.isoeng
dc.relation.ispartofFrontiers in Oncology
dc.subjectOncology
dc.subjectovarian neoplasm
dc.subjectgingerol
dc.subjectcisplatin
dc.subjectapoptosis
dc.subjectangiogenesis
dc.subjectmolecular dynamics simulation
dc.subjectchick embryo
dc.subjectOncology
dc.subjectCancer Research
dc.titleThe inhibitory effect of 6-gingerol and cisplatin on ovarian cancer and antitumor activity: In silico, in vitro, and in vivoen
dc.contributor.institutionCentre for Future Societies Research
dc.contributor.institutionDepartment of Engineering and Technology
dc.contributor.institutionSchool of Physics, Engineering & Computer Science
dc.contributor.institutionBioEngineering
dc.contributor.institutionMaterials and Structures
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionSchool of Computer Science
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85150429116&partnerID=8YFLogxK
rioxxterms.versionofrecord10.3389/fonc.2023.1098429
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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