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dc.contributor.authorDavenport, A.
dc.contributor.authorAshby, M.J.
dc.contributor.authorEaston, P.
dc.contributor.authorElla, S.
dc.contributor.authorBedford, J.
dc.contributor.authorDickerson, Claire
dc.contributor.authorNunez, D.J.
dc.contributor.authorCapper, S.J.
dc.contributor.authorBrown, M.J.
dc.date.accessioned2010-05-19T12:54:44Z
dc.date.available2010-05-19T12:54:44Z
dc.date.issued1990
dc.identifier.citationDavenport , A , Ashby , M J , Easton , P , Ella , S , Bedford , J , Dickerson , C , Nunez , D J , Capper , S J & Brown , M J 1990 , ' A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma : comparison of levels in patients with essential hypertension and normotensive control subjects ' Clinical Science , vol 78 , pp. 261-264 .en
dc.identifier.issn0143-5221
dc.identifier.otherPURE: 107934
dc.identifier.otherPURE UUID: 8f464693-d7e6-4408-b004-d61874b4cf68
dc.identifier.otherdspace: 2299/4495
dc.identifier.otherScopus: 0025181868
dc.identifier.urihttp://hdl.handle.net/2299/4495
dc.identifier.urihttp://www.clinsci.org/cs/078/cs0780261.htmen
dc.descriptionOriginal article can be found at: http://www.clinsci.org/cs/078/cs0780261.htm Copyright The Biochemical Society and the Medical Research Society [Full text of this article is not available in the UHRA]en
dc.description.abstract1. A radioimmunoassay has been developed for measuring endothelin-like immunoreactivity in human plasma using an antibody raised against endothelin-1 which also cross-reacts with big endothelin-1 and endothelin-2 but not endothelin-3. 2. The sensitivity of the assay was 1 fmol/tube with inter- and intra-assay coefficients of variation of 13% and 9%, respectively. Cross-reactivity with endothelin-3 and non-endothelin peptides was less than 1%. 3. Endothelin-like immunoreactivity was present in the plasma of hypertensive patients (n = 25) at a concentration of 5.7 +/- 0.5 pmol/l (mean +/- SEM), which was not significantly different from that of age-matched control subjects (5.1 +/- 0.5 pmol/l). At these levels, endothelin-1 is unlikely to function as a circulating hormone. 4. Within the normotensive group, the concentration of endothelin-like immunoreactivity in plasma was positively correlated with mean arterial blood pressure, but in hypertensive patients it showed a significant negative correlation.en
dc.language.isoeng
dc.relation.ispartofClinical Scienceen
dc.rightsen
dc.titleA sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma : comparison of levels in patients with essential hypertension and normotensive control subjectsen
dc.typeArticleen
dc.contributor.institutionSchool of Educationen
dc.description.statusPeer revieweden
dc.relation.schoolSchool of Education
herts.preservation.rarelyaccessedtrue


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