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dc.contributor.authorPatel, D.D.
dc.contributor.authorLaws, K.R.
dc.contributor.authorPadhi, A.
dc.contributor.authorFarrow, J.
dc.contributor.authorMukhopadhaya, K.
dc.contributor.authorKrishnaiah, R.
dc.contributor.authorFineberg, Naomi
dc.date.accessioned2011-05-25T14:26:28Z
dc.date.available2011-05-25T14:26:28Z
dc.date.issued2010
dc.identifier.citationPatel , D D , Laws , K R , Padhi , A , Farrow , J , Mukhopadhaya , K , Krishnaiah , R & Fineberg , N 2010 , ' The neuropsychology of the schizo-obsessive subtype of schizophrenia : a new analysis ' , Psychological Medicine , vol. 40 , no. 6 , pp. 921-933 . https://doi.org/10.1017/S0033291709991255
dc.identifier.issn0033-2917
dc.identifier.otherPURE: 196081
dc.identifier.otherPURE UUID: d4d93f9f-1162-4d95-a671-91c51c7ac1d0
dc.identifier.otherdspace: 2299/5829
dc.identifier.otherScopus: 77952419003
dc.identifier.otherORCID: /0000-0002-5065-0867/work/124446483
dc.identifier.urihttp://hdl.handle.net/2299/5829
dc.descriptionOriginal article can be found at : http://journals.cambridge.org/ Copyright Cambridge University Press
dc.description.abstractBackground : Interest in the neuro-cognitive profile of patients with schizophrenia and co-morbid obsessive compulsive disorder (schizo-OCD) is rising in response to reports of high co-morbidity rates. Whereas schizophrenia has been associated with global impairment in a wide range of neuro-cognitive domains, OCD is associated with specific deficits featuring impaired performance on tasks of motor and cognitive inhibition involving frontostriatal neuro-circuitry. Method : We compared cognitive function using the CANTAB battery in patients with schizo-OCD (n=12) and a schizophrenia group without OCD symptoms (n=16). The groups were matched for IQ, gender, age, medication, and duration of illness. Results : The schizo-OCD patients made significantly more errors on a task of attentional set-shifting (ID-ED set-shift task). By contrast, no significant differences emerged on the Stockings of Cambridge task, the Cambridge Gamble Task or the Affective Go/NoGo tasks. No correlation emerged between ID-ED performance and severity of schizophrenia, OCD or depressive symptoms, consistent with neurocognitive impairment holding trait rather than state-marker status. Schizo-obsessives also exhibited a trend toward more motor tics emphasizing a neurological contribution to the disorder. Conclusion : Our findings reveal a more severe attentional set-shifting deficit and neurological abnormality that may be fundamental to the neuro-cognitive profile of schizo-OCD. The clinical implications of these impairments merit further exploration in larger studies.en
dc.language.isoeng
dc.relation.ispartofPsychological Medicine
dc.subjectendophenotype
dc.subjectfrontal lobes
dc.subjectobsessive-compulsive
dc.subjectset-shifting
dc.titleThe neuropsychology of the schizo-obsessive subtype of schizophrenia : a new analysisen
dc.contributor.institutionDepartment of Psychology
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionPsychology
dc.contributor.institutionCognitive Neuropsychology
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionDepartment of Psychology and Sports Sciences
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1017/S0033291709991255
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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