dc.contributor.author | Patel, D.D. | |
dc.contributor.author | Laws, K.R. | |
dc.contributor.author | Padhi, A. | |
dc.contributor.author | Farrow, J. | |
dc.contributor.author | Mukhopadhaya, K. | |
dc.contributor.author | Krishnaiah, R. | |
dc.contributor.author | Fineberg, Naomi | |
dc.date.accessioned | 2011-05-25T14:26:28Z | |
dc.date.available | 2011-05-25T14:26:28Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Patel , D D , Laws , K R , Padhi , A , Farrow , J , Mukhopadhaya , K , Krishnaiah , R & Fineberg , N 2010 , ' The neuropsychology of the schizo-obsessive subtype of schizophrenia : a new analysis ' , Psychological Medicine , vol. 40 , no. 6 , pp. 921-933 . https://doi.org/10.1017/S0033291709991255 | |
dc.identifier.issn | 0033-2917 | |
dc.identifier.other | dspace: 2299/5829 | |
dc.identifier.other | ORCID: /0000-0002-5065-0867/work/124446483 | |
dc.identifier.uri | http://hdl.handle.net/2299/5829 | |
dc.description | Original article can be found at : http://journals.cambridge.org/ Copyright Cambridge University Press | |
dc.description.abstract | Background : Interest in the neuro-cognitive profile of patients with schizophrenia and co-morbid obsessive compulsive disorder (schizo-OCD) is rising in response to reports of high co-morbidity rates. Whereas schizophrenia has been associated with global impairment in a wide range of neuro-cognitive domains, OCD is associated with specific deficits featuring impaired performance on tasks of motor and cognitive inhibition involving frontostriatal neuro-circuitry. Method : We compared cognitive function using the CANTAB battery in patients with schizo-OCD (n=12) and a schizophrenia group without OCD symptoms (n=16). The groups were matched for IQ, gender, age, medication, and duration of illness. Results : The schizo-OCD patients made significantly more errors on a task of attentional set-shifting (ID-ED set-shift task). By contrast, no significant differences emerged on the Stockings of Cambridge task, the Cambridge Gamble Task or the Affective Go/NoGo tasks. No correlation emerged between ID-ED performance and severity of schizophrenia, OCD or depressive symptoms, consistent with neurocognitive impairment holding trait rather than state-marker status. Schizo-obsessives also exhibited a trend toward more motor tics emphasizing a neurological contribution to the disorder. Conclusion : Our findings reveal a more severe attentional set-shifting deficit and neurological abnormality that may be fundamental to the neuro-cognitive profile of schizo-OCD. The clinical implications of these impairments merit further exploration in larger studies. | en |
dc.format.extent | 117568 | |
dc.language.iso | eng | |
dc.relation.ispartof | Psychological Medicine | |
dc.subject | endophenotype | |
dc.subject | frontal lobes | |
dc.subject | obsessive-compulsive | |
dc.subject | set-shifting | |
dc.title | The neuropsychology of the schizo-obsessive subtype of schizophrenia : a new analysis | en |
dc.contributor.institution | Department of Psychology | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Health & Human Sciences Research Institute | |
dc.contributor.institution | Psychology | |
dc.contributor.institution | Cognitive Neuropsychology | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.contributor.institution | Department of Psychology and Sports Sciences | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1017/S0033291709991255 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |