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Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesia
(2010-12)
Hyperinnervation of the striatum by serotoninergic (5-HT) terminals occurs after destruction of the dopaminergic nigro-striatal pathway. Recent studies have suggested that non-physiological release of dopamine (DA) formed ...
Continuous rotigotine administration reduces dyskinesia resulting from pulsatile treatment with rotigotine or L-DOPA in MPTP-treated common marmosets
(2010-01)
We previously showed that continuous infusion of rotigotine resulted in less dyskinesia than repeated pulsatile rotigotine administration or repeated oral administration Of L-DOPA in MPTP-treated marmosets. Now we investigate ...
Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction
(2009-10)
Rotigotine is a novel, non-ergoline dopamine D-3/D-2/D-1-receptor agonist for the treatment of Parkinson's disease that can be Continuously delivered by the transdermal route to provide stable plasma levels. Continuous ...
Continuous delivery of ropinirole reverses motor deficits without dyskinesia induction in MPTP-treated common marmosets
(2008-05)
L-DOPA treatment of Parkinson's disease induces a high incidence of motor complications, notably dyskinesia. Longer acting dopamine agonists, e.g. ropinirole, are thought to produce more continuous dopaminergic stimulation ...
3,4-methylenedioxymethamphetamine (ecstasy) inhibits dyskinesia expression and normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates
(2003-10-08)
Ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] was shown to prolong the action of L-3,4-dihydroxyphenylalanine (L-DOPA) while suppressing dyskinesia in a single patient with Parkinson's disease (PD). The clinical basis ...
Behavioural and immunohistochemical changes following supranigral administration of sonic hedgehog in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets
(2002)
Sonic hedgehog (SHH) has trophic actions on dopaminergic cell cultures and protects them from MPP+ toxicity but its in vivo actions have not been explored. We now investigate the effects of unilateral supranigral administration ...
GDNF reverses priming for dyskinesia in MPTP-treated, L-DOPA-primed common marmosets
(2001-02)
Parkinson's disease (PD) is associated with a progressive loss of dopamine neurons in the substantia nigra and degeneration of dopaminergic terminals in the striatum. Although L-DOPA treatment provides the most effective ...