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Browsing by Author "Centre for Research in Mechanisms of Disease and Drug Discovery"
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Disruption of methylarginine metabolism impairs vascular homeostasis
Leiper, James; Nandi, Manasi; Torondel, Belen; Murray-Rust, Judith; Malaki, Mohammed; O'Hara, Bernard; Rossiter, Sharon; Anthony, Shelagh; Madhani, Melanie; Selwood, David; Smith, Caroline; Wojciak-Stothard, Beata; Rudiger, Alain; Stidwill, Ray; McDonald, Neil Q.; Vallance, Patrick (2007-02)Asymmetric dimethylarginine (ADMA) and monomethyl arginine (L-NMMA) are endogenously produced amino acids that inhibit all three isoforms of nitric oxide synthase (NOS)(1). ADMA accumulates in various disease states, ... -
Dopamine induces hyperpolarization of locust salivary gland acinar cells via D1-like receptors.
Keating, Christopher; Orchard, Ian (2001-07)The effect of dopamine on the salivary gland acinar cells of the locust was examined using conventional intracellular recording techniques. Application of dopamine induced a reversible, dose-dependent hyperpolarization of ... -
Dopamine releasing actions of NMDA in rat caudate putamen studied by fast cyclic voltammetry
Iravani, Mahmoud M.; Kruk, Z. L. (1992-07)Investigations in vitro (Clow & Jhamandas, 1989; Krebs et al., 1990) have shown that glutamic acid, acting at NMDA receptors in the absence of Mg2+ can stimulate the release of dopamine (DA) from nerve terminals in the rat ... -
Dramatic developmental changes in larval knockdown response enhance genetic sexing based on DDT resistance in Anopheles stephensi (Diptera: Culicidae)
Malcolm, Colin; Robinson, A. S. (2001-12)Genetic sexing systems based on a conditional lethal require good discrimination between the different phenotypes. DDT resistance in the early instars of Anopheles stephensi Liston is not a good candidate when based on ... -
Drowning in Diversity? A systematic way of clustering a representative set of new psychoactive substances
Zloh, Mire; Samaras, Eleftherios; Calvo-Castro, Jesus; Guirguis, Amira; Stair, Jacqueline; Kirton, Stewart (2017-11-17)New psychoactive substances (NPS) can be generally described as a set of compounds that have been designed to mimic the effects of illegal recreational drugs, but are not subject to restriction or control with respect to ... -
Dysfunction in nitric oxide synthesis in streptozotocin treated rat aorta and role of methylglyoxal
Shamsaldeen, Yousif; Alsugoor, Mahdi; Lione, Lisa; Benham, Christopher (2019-01-05)Diabetic vascular dysfunction is a major complication of diabetes. Methylglyoxal (MGO) is a dicarbonyl metabolite elevated in diabetic plasma that reacts with interstitial molecules to form advanced glycation end products ... -
Dysregulated placental microRNAs in Early and Late onset Preeclampsia
Lykoudi, Alexandra; Kolialexi, Aggeliki; Lambrou, George I; Braoudaki, Maria; Siristatidis, Charalampos; Papaioanou, George Konstantinos; Tzetis, Maria; Mavrou, Ariadni; Papantoniou, Nikolas (2018-01-01)INTRODUCTION: To determine the miRNA expression profile in placentas complicated by Preeclampsia (PE) and compare it to uncomplicated pregnancies. METHODS: Sixteen placentas from women with PE, [11 with early onset PE ... -
Dysregulation of epithelial ion transport and neurochemical changes in the colon of a parkinsonian primate
Coletto, Erika; Tough, Ian; Pritchard, Sara; Hikima, Atsuko; Jackson, Michael; Jenner, Peter; Chaudhuri, K. Ray; Cox, Helen; Iravani, Mahmoud; Rose, Sarah (2021-01-21)The pathological changes underlying gastrointestinal (GI) dysfunction in Parkinson’s disease (PD) are poorly understood and the symptoms remain inadequately treated. In this study we compared the functional and neurochemical ... -
Dysregulation of TRPV4, eNOS and caveolin-1 contribute to endothelial dysfunction in the streptozotocin rat model of diabetes
Shamsaldeen, Yousif; Lione, Lisa; Benham, Christopher (2020-12-05)Endothelial dysfunction is a common complication in diabetes in which endothelium-dependent vasorelaxation is impaired. The aim of this study was to examine the involvement of the TRPV4 ion channel in type 1 diabetic ... -
Ecstasy (3,4-Methylenedioxymethamphetamine) inhibits dyskinesia expression and normalises locomotor activity in parkinsonian primates
Iravani, Mahmoud M.; Jackson, M. J.; Al-Barghouthy, G.; Kouppamaki, M.; Jenner, P. (2002) -
Editorial: Exploring neuroinflammatory pathways that contribute to chronic pain
Lione, Lisa A.; Fisher, Amy (2022-09-15)Chronic pain leading to a reduced quality of life is one of the most important health problems worldwide. It has been estimated that 10% of adults are diagnosed with chronic pain each year. However, despite the high ... -
Editorial: Exploring neuroinflammatory pathways that contribute to chronic pain, volume II
Lione, Lisa A.; Fisher, Amy (2024-06-10) -
Editorial: Glycans: molecules at the interface of immunity and disease
Springer, Stevan A; Siddiqui, Shoib Sawar (2024-01-05) -
Editorial: Microbial interactions of Clostridioides difficile
Goh, Shan; Mullany, Peter; Riley, Thomas V. (2023-01-06) -
Editorial: Recent breakthroughs in the decoding of circulating nucleic acids and their applications to human diseases
El-Daly, Sherien M.; Talaat, Roba M.; Braoudaki, Maria; Youness, Rana A.; Cho, William C. (2023-05-10) -
Editorial: Stem cell technologies meet stem cell biology to shine new light into tropical infectious diseases
Pance, Alena; Rinaldi, Gabriel (2024-05-07) -
Editorial: The use of plant metabolites to ameliorate sequelae of chemotherapy
Vazhappilly, Cijo George; Siddiqui, Shoib Sarwar; Anto, Ruby John; Radhakrishnan, Rajan; Devanga Ragupathi, Naveen Kumar (2023-11-07) -
The effect of exercise and heart rate on fibrinolytic activity
Dewar, H. A.; Zar, M. A.; Smith, N. M.; Iravani, Mahmoud M.; Stappenbeck, R. (1993-06) -
Effect of frequency of stimulation on neurogenic responses of isolated rat epidymal vas deferens
Iravani, Mahmoud M.; Zar, M. A. (1987-12) -
Effect of metronidazole on growth and toxin production by epidemic Clostridium difficile PCR ribotypes 001 and 027 in a human gut model
Freeman, Jane; Baines, Simon D.; Saxton, Katie; Wilcox, Mark H. (2007)We compared the behaviour of Clostridium difficile PCR ribotypes 001 and 027 in a human gut model, and compared the responses to metronidazole exposure.