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Clinical Advances in Obsessive Compulsive Disorder: A Position Statement by the International College of Obsessive Compulsive Spectrum Disorders
Fineberg, Naomi; Hollander, Eric; Pallanti, Stefano; Walitza, Susanne; Grünblatt, Edna; Dell'Osso, Bernardo; Albert, Umberto; Geller, Daniel; Brakoulias, Vlasios; Reddy, Janardhan Y C; Arumugham, Shyam Sundar; Shavitt, Roseli G.; Drummond, Lynne; Grancini, Benedetta; De Carlo, Vera; Cinosi, Eduardo; Chamberlain, Samuel R.; Ioannidis, Konstantinos; Rodriguez, Carolyn; Garg, Kabir; Castle, David; Van Ameringen, Michael; Stein, Dan J.; Carmi, Lior; Zohar, Joseph; Menchon Magrina, Jose (2020-07)In this position statement, developed by The International College of Obsessive-Compulsive Spectrum Disorders, a group of international experts responds to recent developments in the evidence-based management of ... -
The clinical and financial implications of a decade of prostate biopsies in the NHS : analysis of Hospital Episode Statistics data 2008–2019
Tamhankar, Ashwin Sunil; El-Taji, Omar; Vasdev, Nikhil; Foley, Charlotte; Popert, Rick; Adshead, Jim (2020-04-22)Objective: To evaluate the clinical and financial implications of a decade of prostate biopsies performed in the UK National Health Service (NHS) through the transrectal (TR) vs the transperineal (TP) route. Methods: We ... -
Clinical and neurocognitive changes with modafinil in obsessive–compulsive disorder : a case report
Dittrich, W.; Johansen, T.; Padhi, A.; Smith, I.E.; Chamberlain, S.R.; Fineberg, Naomi (2010)There are limited treatment options for co-occurring sleep disorders and obsessive-compulsive disorder (OCD). We postulated that Modafinil (Provigil) [2-{(diphenylmethyl) sulfinyl acetamide}] a non-amphetamine wakefulnes ... -
The clinical challenges of synthetic cathinones
Schifano, Fabrizio; Napoletano, Flavia; Arillotta, Davide; Zangani, Caroline; Gilgar, Liam; Guirguis, Amira; Corkery, John; Vento, Alessandro (2019-11-01)Within the new psychoactive substances (NPS) scenario, several hundreds of different molecules, mostly including synthetic cannabinoids and cathinones, have so far been identified. The aims of the paper were to: (a) identify ... -
The clinical effectiveness and cost-effectiveness of treat-to-target strategies in rheumatoid arthritis : a systematic review and cost-effectiveness analysis
Wailoo, Allan; Hock, Emma S; Stevenson, Matt; Martyn-St James, Marrissa; Rawdin, Andrew; Simpson, Emma; Wong, Ruth; Dracup, Naila; Scott, David L; Young, Adam (National Institute for Health Research (NIHR), 2017-12-01)BACKGROUND: Treat to target (TTT) is a broad concept for treating patients with rheumatoid arthritis (RA). It involves setting a treatment target, usually remission or low disease activity (LDA). This is often combined ... -
Clinical experience and psychometric properties of the Cardiff Acne Disability Index (CADI)
Abdelrazik, Y.T.; Ali, F.M.; Salek, M.S.; Finlay, A.Y. (2021-07-22)Summary: The Cardiff Acne Disability Index (CADI) is a questionnaire designed to measure the quality of life of teenagers and young adults with acne. It has been used clinically and within therapeutic research globally. ... -
Clinical Implications of Kratom (Mitragyna speciosa) Use: a Literature Review
Prevete, Elisabeth; Kuypers, Kim Paula Colette; Theunissen, Eef Lien; Esposito, Gianluca; Ramaekers, Johannes Gerardus; Pasquini, Massimo; Corazza, Ornella (2023-06-30)Purpose of Review: This work aims to provide an up-to-date review of the preclinical and clinical scientific literature on the therapeutic value of kratom to better understand the underlying mechanisms related to its use ... -
Clinical outcomes of low‑pressure pneumoperitoneum in minimally invasive urological surgery
West, Alexander; Hayes, John; Bernstein, D E; Krishnamoorthy, Mahesh; Lathers, Steven; Tegan, Gary; Teoh, Jeremy Yuen-Chun; Dasgupta, Prokar; Decaestecker , Karel; Vasdev, Nikhil (2022-01-30)The adoption of minimally invasive laparoscopic techniques has revolutionised urological practice. This necessitates a pneumoperitoneum (PNP) and the impact the PNP pressure has on post-operative outcomes is uncertain. ... -
Clozapine, neutropenia and Covid-19: should clinicians be concerned? 3 months report
Bonaccorso, Stefania; Ricciardi, Angelo; Ouabbou, Sophie; Theleritis, Christos; Ross-Michealides, Arabella; Metastasio, Antonio; Stewart, Neil; Mohammed, Marwa; Schifano, Fabrizio (2021-05)Background: Clozapine is among the most effective antipsychotics used for treatment resistant schizophrenia. Adverse reactions to clozapine include neutropenia. In March 2020, at the start of the Coronavirus -19 pandemic, ... -
Clozapine-related obsessive-compulsive symptoms and their impact on wellbeing: a naturalistic longitudinal study
Parkin, Kaherine; Chen, Shanquan; Biria, Marjan; Plaistow, James; Beckwith, Helen; Jarratt-Barnham, Isaac; Segarra, Nuria; Worbe, Yulia; Fineberg, Naomi; Cardinal, Rudolf N; Robbins, Trevor W.; Fernandez-Egea, Emilio (2023-05-13)Background Obsessive–compulsive symptoms (OCS) are commonly associated with clozapine treatment but are frequently overlooked by clinicians despite their potential impact on patients' quality of life. In this study, we ... -
Club Drugs: Psychotropic Effects and Psychopathological Characteristics of a Sample of Inpatients
Martinotti, Giovanni; Giorgetti, Raffaele; Schifano, Fabrizio; di Giannantonio, Massimo (2020-08-31)Background: growing evidence supports the possibility of significant psychiatric consequences related to novel and traditional psychoactive substance consumption. The problem of differential diagnosis has hampered research ... -
Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery
Perez Diaz, Noelia; Lione, Lisa; Hutter, Victoria; Mackenzie, Louise Susan (MDPI Multidisciplinary Digital Publishing Institute, 2022-05-01)Peroxisome proliferator activated receptor beta/delta (PPARβ/δ) is a nuclear receptor ubiquitously expressed in cells, whose signaling controls inflammation. There are large discrepancies in understanding the complex role ... -
Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery
Perez Diaz, Noelia; Lione, Lisa; Hutter, Victoria; Mackenzie, Louise Susan (2021-03-19)Peroxisome proliferator activated receptor beta/delta (PPARβ/δ) is a nuclear receptor ubiquitously expressed in cells, whose signaling controls inflammation. There are large discrepan-cies in understanding the complex role ... -
Cognitive Assessment Instrument of Obsessions and Compulsions (CAIOC-13) : A new 13-item scale for evaluating functional impairment associated with OCD
Dittrich, W.; Johansen, T.; Fineberg, Naomi (2010)The Cognitive Assessment Instrument of Obsessions and Compulsions (CAIOC) was designed as a novel instrument for clinicians to assess the main cognitive and executive impairments that are hypothesized to underpin the impact ... -
Cognitive behavioural therapy for anxiety in children and young people on the autism spectrum: a systematic review and meta-analysis
Sharma, Shivani; Hucker, Abigail; Matthews, Terry; Grohmann, Dominique; Laws, Keith R. (2021-10-01)Abstract: Background: Anxiety is common in youth on the autism spectrum and cognitive behavioural therapy (CBT) has been adapted to address associated symptoms. The aim of the current systematic review and meta-analysis ... -
Cognitive Behavioural Therapy with Exposure and Response Prevention in the treatment of Obsessive-Compulsive Disorder: A systematic review and meta-analysis of randomised controlled trials
Reid, Jemma; Laws, Keith; Drummond, Lynne M; Vismara, Matteo; Grancini, Benedetta; Mpavaenda, Davis; Fineberg, Naomi (2021-04-01)Background: Cognitive behavioural therapy (CBT), incorporating exposure and response prevention (ERP) is widely recognised as the psychological treatment of choice for obsessive-compulsive disorder (OCD). Uncertainty remains ... -
Cognitive deficits in problematic internet use : meta-analysis of 40 studies
Ioannidis, Konstantinos; Hook, Roxanne; Goudriaan, Anna E; Vlies, Simon; Fineberg, Naomi A; Grant, Jon E; Chamberlain, Samuel R (2019-11-01)BACKGROUND: Excessive use of the internet is increasingly recognised as a global public health concern. Individual studies have reported cognitive impairment in problematic internet use (PIU), but have suffered from various ... -
Cognitive dysfunction in body dysmorphic disorder : new implications for nosological systems and neurobiological models
Jefferies-Sewell, Kiri; Chamberlain, Samuel R; Fineberg, Naomi A; Laws, Keith R (2017-02-28)Introduction Body dysmorphic disorder (BDD) is a debilitating disorder, characterized by obsessions and compulsions relating specifically to perceived appearance, and which has been newly classified within the Diagnostic ... -
Cognitive performance and specific deficits in OCD symptom dimensions : II. Spatial memory and impaired recognition of visuospatial object locations
Dittrich, Winand; Johansen, T.; Fineberg, Naomi; Landro, N.I. (2011)Objective : To investigate spatial recognition abilities and working memory in obsessive-compulsive disorder (OCD) patients grouped according to their primary symptom dimensions. Memory has always occupied a central position ... -
Cognitive performance and specific deficits in OCD symptom dimensions : III. Decision-making and impairments in risky choices
Dittrich, Winand; Johansen, T.; Landro, N.I.; Fineberg, Naomi (2011)Objective : To investigate ambiguous and risky decision-making in obsessive-compulsive disorder (OCD) patients grouped according to established primary symptom dimensions. The difficulties of OCD patients in real-life quite ...