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Browsing by Author "Centre for Research in Mechanisms of Disease and Drug Discovery"
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Enantioselective Synthesis of the Cyclopiazonic Acid Family Using Sulfur Ylides
Zhurakovskyi, Oleksandr; Türkmen, Yunus E; Löffler, Lorenz E; Moorthie, Vijayalakshmi A; Chen, C Chun; Shaw, Michael A; Crimmin, Mark R; Ferrara, Marco; Ahmad, Mushtaq; Ostovar, Mehrnoosh; Matlock, Johnathan V; Aggarwal, Varinder K (2018-01-26)A convergent, nine-step (LLS), enantioselective synthesis of α-cyclopiazonic acid and related natural products is reported. The route features a) an enantioselective aziridination of an imine with a chiral sulfur ylide; ... -
Enhancing resolution and sensitivity of 17O solid-state NMR through combining double rotation, 1H decoupling and satellite modulation for biomolecular applications
Howes, P.; Anupolde, T.; Lemaitre, V.; Kukol, A.; Watts, A.; Samosone, A.; Smith, M.E.; Dupree, R. (2006) -
Enzyme Kinetics Lecture Notes
Kukol, A. (Create Space Independent Publishing Platform, 2015-08-14)This book covers the topic of enzyme kinetics for a three-year undergraduate programme in bioscience. It begins with a thorough introduction into chemical kinetics, which forms the basis of all enzyme kinetics application. ... -
Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body
Panousopoulou, Eleni; Hobbs, Carl; Mason, Ivor; Green, Jeremy B A; Formstone, Caroline J (2016-05-01)Epiboly is a morphogenetic process that is employed in the surface ectoderm of anamniotes during gastrulation to cover the entire embryo. We propose here that mammals also utilise this process to expand the epidermis and ... -
Establishing the importance of oil-membrane interactions on the transmembrane diffusion of physicochemically diverse compounds
Najib, Omaima N.; Martin, Gary P; Kirton, Stewart; Sallam, Al-Sayed; Murnane, Darragh (2016-06-15)The diffusion process through a non-porous barrier membrane depends on the properties of the drug, vehicle and membrane. The aim of the current study was to investigate whether a series of oily vehicles might have the ... -
Evaluating academic answers generated using ChatGPT
Fergus, Suzanne; Botha, Michelle; Ostovar, Mehrnoosh (2023-04-11)The integration of technology in education has become ever more prioritized since the COVID-19 pandemic. Chat Generative Pre-Trained Transformer (ChatGPT) is an artificial intelligence technology that generates conversational ... -
Evaluation of a novel virtual screening strategy using receptor decoy binding sites
Patel, Hershna; Kukol, Andreas (2016-08-23)Virtual screening is used in biomedical research to predict the binding affinity of a large set of small organic molecules to protein receptor targets. This report shows the development and evaluation of a novel yet ... -
Evaluation of antimicrobial activity of ceftaroline against Clostridium difficile and propensity to induce C. difficile infection in an in vitro human gut model
Baines, Simon D.; Chilton, Caroline H.; Crowther, Grace S.; Todhunter, Sharie L.; Freeman, Jane; Wilcox, Mark H. (2013)OBJECTIVES: To examine the effects of exposure to ceftaroline or ceftriaxone on the epidemic Clostridium difficile strain PCR ribotype 027 and the indigenous gut microflora in an in vitro human gut model. Additionally, the ... -
Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model
Baines, Simon D.; Noel, Alan R.; Huscroft, Grace S.; Todhunter, Sharie L.; O'Connor, Rachael; Hobbs, Joanne K.; Freeman, Jane; Lovering, Andy M.; Wilcox, M. H. (2011)Therapeutic options in Clostridium difficile infection (CDI) are limited. We examined linezolid activity in vitro and potential therapeutic efficacy using a gut model of CDI. -
Evaluation of NVB302 versus vancomycin activity in an in vitro human gut model of Clostridium difficile infection
Crowther, Grace S; Baines, Simon D.; Todhunter, Sharie L; Freeman, Jane; Chilton, Caroline H; Wilcox, Mark H (2013)OBJECTIVES: First-line treatment options for Clostridium difficile infection (CDI) are limited. NVB302 is a novel type B lantibiotic under evaluation for the treatment of CDI. We compared the responses to NVB302 and ... -
Evaluation of the effect of oritavancin on Clostridium difficile spore germination, outgrowth and recovery
Chilton, C. H.; Freeman, J.; Baines, Simon D.; Crowther, G. S.; Nicholson, S.; Wilcox, M. H. (2013)OBJECTIVES: Previous work suggests oritavancin may be inhibitory to Clostridium difficile spores. We have evaluated the effects of oritavancin exposure on C. difficile spore germination, outgrowth and recovery. METHODS: ... -
Evidence for neuropeptide-Y (NPY) as the probable non-cholinergic motor transmitter in rat urinary-bladder in vitro
Iravani, Mahmoud M.; Zar, M. A. (1988-09) -
Evidence that Diclofenac and Celecoxib are thyroid hormone receptor beta antagonists
Zloh, Mire; Perez Diaz, Noelia; Tang, Leslie; Patel, Pryank; MacKenzie, Louise Susan (2016-02-01)Long term use of NSAIDs is linked to side effects such as gastric bleeding and myocardial infarction. AIMS: Use of in silico methods and pharmacology to investigate the potential for NSAIDs diclofenac, celecoxib and naproxen ... -
Evolutionary conservation of human ketodeoxynonulosonic acid production is independent of sialoglycan biosynthesis
Kawanishi, Kunio; Saha, Sudeshna; Diaz, Sandra; Vaill, Michael; Sasmal, Aniruddha; Siddiqui, Shoib S; Choudhury, Biswa P; Sharma, Kumar; Chen, Xi; Schoenhofen, Ian C; Sato, Chihiro; Kitajima, Ken; Freeze, Hudson H; Münster-Kühnel, Anja; Varki, Ajit (2021-03-01)Human metabolic incorporation of nonhuman sialic acid (Sia) N-glycolylneuraminic acid into endogenous glycans generates inflammation via preexisting antibodies, which likely contributes to red meat-induced atherosclerosis ... -
Evolutionary conservation of influenza A PB2 sequences reveals potential target sites for small molecule inhibitors
Patel, Hershna; Kukol, Andreas (2017-09-01)The influenza A basic polymerase protein 2 (PB2) functions as part of a heterotrimer to replicate the viral RNA genome. To investigate novel PB2 antiviral target sites, this work identified evolutionary conserved regions ... -
Experimentally based orientational refinement of membrane protein models : a structure for the Influenza A M2 H+ channel
Kukol, A.; Adams, P.D.; Rice, L.M.; Brunger, A.T.; Arkin, I.T. (1999)The structure determination of membrane proteins is still a difficult task. Considering the fact that as many as 30% or more of cellular proteins are associated with the membrane (Arkin et al., 1997a), the paucity of high ... -
Exploring models of the influenza A M2 channel: MD simulations in a phospholipid bilayer
Forrest, L. R.; Kukol, A.; Arkin, I.T.; Tieleman, D. P.; Sansom, M. S. P. (2000-01)The M2 protein of influenza A virus forms homotetrameric helix bundles, which function as proton-selective channels. The native form of the protein is 97 residues long, although peptides representing the transmembrane ... -
Extracellular vesicles could be a putative posttranscriptional regulatory mechanism that shapes intracellular RNA levels in Plasmodium falciparum
Kioko, Mwikali; Pance, Alena; Mwangi, Shaban; Goulding, David; Kemp, Alison; Rono, Martin; Ochola-Oyier, Lynette Isabella; Bull, Pete C.; Bejon, Philip; Rayner, Julian C.; Abdi, Abdirahman I. (2023-10-13)Plasmodium falciparum secretes extracellular vesicles (PfEVs) that contain parasite-derived RNA. However, the significance of the secreted RNA remains unexplored. Here, we compare secreted and intracellular RNA from asexual ... -
Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract
Beyak, M; Bulmer, D; Jiang, W; Keating, Christopher; Rong, W; Grundy, D (McGraw-Hill, 2006) -
The family of DOF transcription factors in Brachypodium distachyon : Phylogenetic comparison with rice and barley DOFs and expression profiling
Hernando-Amado, Sara; González-Calle, Virginia; Carbonero, Pilar; Barrero-Sicilia, Cristina (2012-11-05)Background: Transcription factors (TFs) are proteins that have played a central role both in evolution and in domestication, and are major regulators of development in living organisms. Plant genome sequences reveal that ...