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Now showing items 161-180 of 1037
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Comparison of the registration process of the Medicines Control Authority of Zimbabwe with Australia, Canada, Singapore, and Switzerland: Benchmarking best practices
Sithole, Tariro; Salek, Sam; Mahlangu, Gugu; Walker, Stuart (2021-10-20)Background: Benchmarking regulatory systems of low- and middle-income countries with mature systems provides an opportunity to identify gaps, enhance review quality, and reduce registration timelines, thereby improving ... -
A comparison of urology training across five major english-speaking countries
Naik, Rishi; Mandal, Indrajeet; Hampson, Alexander; Casey, Rowan; Vasdev, Nikhil (2020-03-20)Background: Urology is a rapidly evolving specialty, although wide variations exist between training programs in different countries. We aimed to compare the status of urology training in 5 English-speaking countries. ... -
Compounds for the treatment of pain : WO2004/078183
School of Life and Medical Sciences; TRP Ion channels; Centre for Research in Mechanisms of Disease and Drug Discovery; Department of Clinical, Pharmaceutical and Biological Science; Basic and Clinical Science Unit; Centre for Health Services and Clinical Research; Lione, Lisa; Richardson, P.J.; Lee, K. (2007) -
Compulsive sexual behavior disorder in 42 countries: Insights from the International Sex Survey and introduction of standardized assessment tools
Liverpool John Moores University's research team; Ponce, Fernando P.; Quintana, Gonzalo R.; Quintero Garzola, Gabriel C.; Ramos-Diaz, Jano; Rigaud, Kévin; Rousseau, Ann; De Tubino Scanavino, Marco; Schulmeyer, Marion K.; Sharan, Pratap; Shibata, Mami; Shoib, Sheikh; Sigre Leirós, Vera L.; Sniewski, Luke; Spasovski, Ognen; Steibliene, Vesta; Stein, Dan J.; Strizek, Julian; Štulhofer, Aleksandar; Ünsal, Berk C.; Vaillancourt-Morel, Marie-Pier (2023-06-29)Background and aims Despite its inclusion in the 11th revision of the International Classification of Diseases, there is a virtual paucity of high-quality scientific evidence about compulsive sexual behavior disorder (CSBD), ... -
Compulsivity Reveals a Novel Dissociation between Action and Confidence
Vaghi, Matilde M.; Luyckx, Fabrice; Sule, Akeem; Fineberg, Naomi A.; Robbins, Trevor W.; De Martino, Benedetto (2017-10-11)Confidence and actions are normally tightly interwoven—if I am sure that it is going to rain, I will take an umbrella—therefore, it is difficult to understand their interplay. Stimulated by the ego-dystonic nature of ... -
Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder : remediating effects of dopaminergic D2/3 receptor agents
Kanen, Jonathan W; Ersche, Karen D; Fineberg, Naomi; Robbins, Trevor W; Cardinal, Rudolf N (2019-08-01)RATIONALE: Disorders of compulsivity such as stimulant use disorder (SUD) and obsessive-compulsive disorder (OCD) are characterised by deficits in behavioural flexibility, some of which have been captured using probabilistic ... -
Concentrations of mephedrone in cases of fatal and non-fatal clinical intoxications
Papaseit, E.; Olesti, E.; de la Torre, R.; Corkery, John; Torrens, Marta; Magi, Farré (2017-10-23) -
Concepts of mental disorders in the United Kingdom : Similarities and differences between the lay public and psychiatrists
Butlin, Ben; Laws, Keith; Read, Rebecca; Broome, Matthew D; Sharma, Shivani (2019-09-01)BACKGROUND: The lay public often conceptualise mental disorders in a different way to mental health professionals, and this can negatively impact on outcomes when in treatment. AIMS: This study explored which disorders the ... -
Conflicting regulations on medicines and controlled drugs may expose pharmacists to criminal liability
Gallagher, Cathal (2021-03-29) -
The consequences of drug misuse on post-marketing surveillance
Schifano, Fabrizio; Papanti, Duccio; Orsolini, Laura; Corkery, John (2016-04-25)Over the past decade, the ‘traditional’ drug scenario has shown significant changes because of the emergence of a range of molecules, e.g. the novel psychoactive substances (NPS), which are either already existing or newly ... -
Conservative care for ESRD in the United Kingdom : a national survey
Okamoto, Ikumi; Tonkin-Crine, Sarah; Rayner, Hugh; Murtagh, Fliss E M; Farrington, Ken; Caskey, Fergus; Tomson, Charles; Loud, Fiona; Greenwood, Roger; O'Donoghue, Donal J; Roderick, Paul (2015-01-07)BACKGROUND AND OBJECTIVES: Conservative kidney management (CKM) has been developed in the United Kingdom (UK) as an alternative to dialysis for older patients with stage 5 CKD (CKD5) and multiple comorbidities. This national ... -
Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction
Stockwell, K. A.; Scheller, D.; Rose, S.; Jackson, M. J.; Tayarani-Binazir, K.; Iravani, Mahmoud M.; Smith, L. A.; Olanow, C. W.; Jenner, P. (2009-10)Rotigotine is a novel, non-ergoline dopamine D-3/D-2/D-1-receptor agonist for the treatment of Parkinson's disease that can be Continuously delivered by the transdermal route to provide stable plasma levels. Continuous ... -
Continuous delivery of ropinirole reverses motor deficits without dyskinesia induction in MPTP-treated common marmosets
Stockwell, K. A.; Virley, D. J.; Perren, M.; Iravani, Mahmoud M.; Jackson, M. J.; Rose, S.; Jenner, P. (2008-05)L-DOPA treatment of Parkinson's disease induces a high incidence of motor complications, notably dyskinesia. Longer acting dopamine agonists, e.g. ropinirole, are thought to produce more continuous dopaminergic stimulation ... -
Continuous rotigotine administration reduces dyskinesia resulting from pulsatile treatment with rotigotine or L-DOPA in MPTP-treated common marmosets
Stockwell, K. A.; Scheller, D. K. A.; Smith, L. A.; Rose, S.; Iravani, Mahmoud M.; Jackson, M. J.; Jenner, P. (2010-01)We previously showed that continuous infusion of rotigotine resulted in less dyskinesia than repeated pulsatile rotigotine administration or repeated oral administration Of L-DOPA in MPTP-treated marmosets. Now we investigate ... -
Continuous subcutaneous infusion of pramipexole protects against lipopolysaccharide-induced dopaminergic cell death without affecting the inflammatory response
Iravani, Mahmoud M.; Sadeghian, Mona; Leung, Clement C. M.; Tel, Banu C.; Rose, Sarah; Schapira, Anthony H.; Jenner, Peter (2008-08)The D2/D3 dopamine receptor agonist pramipexole, protects against toxin-induced dopaminergic neuronal destruction but its mechanism of action is unknown. Inflammation following glial cell activation contributes to cell ... -
Continuous vs pulsatile administration of rotigotine in rat and monkey models of Parkinson's disease: A comparison
Scheller, D. K. A.; Schmidt, W. J.; Jackson, M. J.; Ruess, U.; Stockwell, K.; Heindl, M.; Iravani, Mahmoud M.; Tayarani-Binazir, K.; Rose, S.; Jenner, P. (2008) -
Contractile dysfunction and nitrergic dysregulation in small intestine of a primate model of Parkinson’s disease : contractile dysfunction in MPTP-treated primate ileum
Coletto, E; Dolan, John S; Pritchard, Sara; Gant, Alex; Hikima, Atsuko; Jackson, Michael J; Benham, Christopher; Chaudhuri, K. Ray; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud (2019-06-10)Bowel dysfunction is a common non-motor symptom in Parkinson's disease (PD). The main contractile neurotransmitter in the GI tract is acetylcholine (ACh), while nitric oxide (NO) causes the relaxation of smooth muscle in ... -
Contribution of drugs to drownings in Scotland, 1996-2020
Corkery, John; Martinotti, Giovanni; Schifano, Fabrizio (2022-08-30)Objective Psychoactive substances use (including alcohol) can affect risk perception, leading to accidents and deaths. There is little detailed or up-to-date information on the role of drugs in United Kingdom (UK) drownings. ... -
Contributions of treatment centre and patient characteristics to patient-reported experience of haemodialysis: A national cross-sectional study
Hawkins, Janine; Smeeton, Nigel; Busby, Amanda; Wellsted, David; Rider, Beth; Jones, Julia; Steinkamp, Retha; Stannard, Catherine; Gair, Rachel; Van Der Veer, Sabine; Corps, Claire; Farrington, Kenneth (2021-04-14)OBJECTIVES: To examine the relative importance of patient and centre level factors in determining self-reported experience of care in patients with advanced kidney disease treated by maintenance haemodialysis (HD). DESIGN: ...