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Response to transplanted adult Ostertagia ostertagi in calves
McKellar, Quintin; Duncan, J. L.; Armour, J.; McWilliam, P. (1986)Plasma pepsinogen levels became elevated in groups of recipient calves immediately after transplant with adult Ostertagia ostertagi. These rises occurred in both previously parasite-naive calves and in calves which had ... -
Ringworm in housed sheep
McKellar, Quintin; Fishwick, G.; Rycroft, A. (1987-08) -
RNA isolation and quantitative PCR from HOPE- and formalin-fixed bovine lymph node tissues
Witchell, J.; Varshney, D.; Gajjar, T.; Wangoo, A.; Goyal, M. (2008)The use of RNA extracted from HOPE fixed tissues in quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) is fairly novel. We compared qRT-PCR analysis of formalin and HOPE fixed, paraffin embedded lymph ... -
Role of ABC transporters in veterinary drug research and parasite resistance
Alvarez, Ana I.; Merino, Gracia; Molina, Antonio J.; Pulido, Mavis M.; McKellar, Quintin; Prieto, Julio G. (2006)A considerable body of research has been carried out in order to throw light on the pharmacological and toxicological impact of ATP-binding cassette (ABC) drug efflux transporters such as P-glycoprotein and Breast Cancer ... -
Secondary bacterial infections following an outbreak of equine influenza
Sarasola, P.; Taylor, D. J.; Love, S.; McKellar, Quintin (1992-11) -
The sequential development of type I and type II ostertagiasis in young cattle with special reference to biochemical and serological changes
Entrocasso, C.; McKellar, Quintin; Parkins, J. J.; Bairden, K.; Armour, J.; Kloosterman, A. (1986-08)The sequential development of Type I and Type II ostertagiasis over a 2-year period in the same naturally infected cattle is described for the first time. Particular reference is made to biochemical and serological changes. ... -
Serum thromboxane generation by platelets in several domestic animal species
McKellar, Quintin; Nolan, A. M.; Galbraith, E. A. (1990)Blood collected from calves, sheep, goats, pigs, dogs, horses, ponies and donkeys, was allowed to clot under standard conditions. Thromboxane B2 generated during the clotting process was measured by radioimmunoassay in ... -
Some observations on the pharmacological properties of ivermectin during treatment of a mite infestation in mice
Conole, J.; Wilkinson, M.J.; McKellar, Quintin (2003-07)Ivermectin has become one of the most widely used drugs for the treatment of parasitic infections in laboratory rodents. Despite its wide popularity, little has been published regarding its pharmacokinetic properties in ... -
Stability of penicillin G, ampicillin, amikacin and oxytetracycline and their interactions with food in in vitro simulated equine gastrointestinal contents
McKellar, Quintin; Horspool, L. J. (1995-05)Penicillin G was extensively (84.7 per cent) and amikacin moderately (14.4 per cent) degraded when incubated for one hour in a chloride buffer at pH 1.9 designed to mimic the equine gastric pH. Ampicillin and oxytetracycline ... -
Stereospecific pharmacodynamics and pharmacokinetics of carprofen in the dog
McKellar, Quintin; Delatour, P.; Lees, P. (1994-12)The non-steroidal anti-inflammatory drug (NSAID) carprofen (CPF) contains a single chiral centre. It was administered orally to Beagle dogs as a racemate (rac-CPF) at a dose of 4 mg per kg body weight and as individual ... -
Stimulated pepsinogen secretion from dispersed abomasal glands exposed to Ostertagia species secretion
McKellar, Quintin; Mostofa, M.; Eckersall, P. D. (1990)Carbachol and secretions from Ostertagia species parasites significantly (P less than 0.001) stimulated isolated preparations of dispersed gastric glands from bovine and ovine abomasal mucosa to secrete pepsinogen. Atropine ... -
Strategic use of anthelmintics for parasitic nematodes in cattle and sheep
McKellar, Quintin (1988-11)Treatment regimes for the control of parasitic nematodes in cattle and sheep are reviewed. The advantages and disadvantages of each strategy are outlined and the veterinarian's judgement of the management and economic ... -
Synthesis and antibacterial activity of benzo[4,5]isothiazolo[2,3-a]pyrazine-6,6-dioxide derivatives
Bassin, Jatinder; Botha, Michelle; Garikipati, Rajesh; Goyal, Madhu; Martin, Lee; Shah, Amit (2017-11-04)We have developed a simple and efficient synthetic route, starting from easily available starting materials, to the ring system benzo[4,5]isothiazolo[2,3-a]pyrazine-6,6-dioxide. A series of chalcones were synthesized which ... -
Synthesis and Antimicrobial Activity of 1,2-Benzothiazine Derivatives
Patel, Chandani; Bassin, Jatinder; Scott, Mark; Flye, Jenna; Hunter, Ann; Martin, Lee; Goyal, Madhu (2016-06-30)A number of 1,2-benzothiazines have been synthesized in a three-step process. Nine chalcones 1-9 bearing methyl, fluoro, chloro and bromo substituents were chlorosulfonated with chlorosulfonic acid to generate the chalcone ... -
Synthesis and evaluation of antibacterial activity of series of novel diketones
Rossiter, Sharon; Zloh, Mire; Bassin, Jatinder; Singh, Jagbir; Goyal, Madhu (2015-11-26) -
Synthesis and evaluation of chalcones and isobenzofuranones for their antimycobacterial activity.
Anagani, Bhavani; Bassin, Jatinder; Benham, Christopher; Goyal, Madhu (2015-11-26) -
Synthesis and Spectral Characterization of Benzo[6,7] [1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives
Bassin, Jatinder; Anagani, Bhavani; Benham, Christopher; Goyal, Madhu; Hashemian , Maryam; Gerhard, Ute (2016-07-23)A simple synthetic route to benzo[6,7][1,5]diazocino[2,1-a]isoindol-12(14H)-one ring system is developed from readily available starting materials 3-(2-oxo-2-phenylethyl) isobenzofuran-1(3H)-ones and 2-(aminomethyl)aniline ... -
Therapie Anthelminthique Bovins les systemes remanents
McKellar, Quintin (1993) -
Time dependent expression of cytokines in Mycobacterium bovis infected cattle lymph nodes
Witchell, J.; Maddipatia, S.V.P.K.; Wangoo, A.; Vordermeier, M.; Goyal, M. (2010)Advancements in the current diagnostic and vaccination protocols employed against bovine tuberculosis rely heavily upon a sound knowledge of the bovine immunological response. Central to this is the importance of timing ... -
Tuberculin screening of some selected Fulani lactating cows in north-central Nigeria
Abubakar, A.; Alan, L.; Okaiyeto, O.; Kudi, A. C.; Abdullahi, S. U.; Brooks, P. H.; Goyal, Madhu (2013-10)The prevalence of mycobacterial infection among lactating Fulani cows was investigated in the Federal Capital Territory, Abuja and Kaduna State of Nigeria. Tuberculin testing using single comparative intradermal tuberculin ...