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Deoxycholic acid activates colonic afferent nerves via 5-HT3 receptor dependent and independent mechanisms
Yu, Yang; Villalobos- Hernandez, Egina; Pradhananga, Sabindra; Baker, Corey; Keating, Christopher; Grundy, David; Lomax, Allan; Reed, David (2019-09-01)Increased bile acids in the colon can evoke increased epithelial secretion resulting in diarrhea, but little is known about whether colonic bile acids contribute to abdominal pain. This study aimed to investigate the ... -
Depression and clinical outcomes in CKD: do anti-depressants play a role? (EQUAL study)
Chilcot, Joseph; Picariello, Federica; Farrington, Ken (2022-08-01) -
Depression Symptoms in Haemodialysis Patients Predict All-Cause Mortality but Not Kidney Transplantation : A Cause-Specific Outcome Analysis
Chilcot, Joseph; Guirguis, Ayman; Friedli, Karin; Almond, Michael K; Day, Clara; Da Silva Gane, Maria; Davenport, Andrew; Fineberg, Naomi A.; Spencer, Benjamin; Wellsted, David; Farrington, Ken (2017-07-31)Background: Depression is common in haemodialysis (HD) patients and associated with poor outcomes. Purpose: To evaluate whether depression symptoms predict survival and transplantation in a large sample of haemodialysis ... -
Descriptive research into large-scale user data from an established alcohol identification and brief advice (IBA) intervention website
Kerr, Dylan Andrew; Corkery, John Martin (figshare, 2024-01-16)Alcohol misuse causes significant health harms, including early mortality, increased healthcare and wider governmental costs. Identification and Brief Advice (IBA) interventions can reduce alcohol consumption, prevent ... -
Design and characterisation of a novel in vitro skin diffusion cell system for assessing mass casualty decontamination systems
Matar, H.; Larner, J.; Kansagra, S.; Atkinson, K. L.; Skamarauskas, J. T.; Amlot, R.; Chilcott, Robert (2014-06-30)The efficient removal of contaminants from the outer surfaces of the body can provide an effective means of reducing adverse health effects associated with incidents involving the accidental or deliberate release of hazardous ... -
Design, Synthesis and Antimicrobial Evaluation of the in vitro Efficacy of Novel Diketones
Garikipati, Rajesh; Mohammed, Olufunmilayo; Rossiter, Sharon; Baines, Simon; Bassin, Jatinder; Goyal, Madhu (2015-11-26)A series of novel diketones were designed and synthesised in an attempt to develop potent antimicrobial agents. Their structures were confirmed by spectroscopic techniques i.e. 1H and 13C-NMR, IR and LC-MS. The minimum ... -
A Design-of-Experiments Approach to Developing Thermoresponsive Gelators From Complex Polymer Mixtures
Kirton, Stewart; Stair, Jacqueline; Abou Shamat, Mohamad; Calvo-Castro, Jesus; Cook, Michael T. (2020-10-13)This study investigated the effects of additives on the properties of poloxamer (P) 407 thermogels, employing a design-of-experiments (DoE) approach. P407 is a thermoresponsive triblock copolymer that exhibits a solution ... -
Designer Benzodiazepines’ Activity on Opioid Receptors: A Docking Study
Catalani, Valeria; Botha, Michelle; Corkery, John Martin; Guirguis, Amira; Vento, Alessandro; Schifano, Fabrizio (2022-09-22)BACKGROUND: Previous studies have reported that benzodiazepines (BZDs) seem to enhance euphoric and reinforcing properties of opioids in opioid users so that a direct effect on opioid receptors has been postulated, together ... -
Detection of Newly Emerging Psychoactive Substances Using Raman Spectroscopy and Chemometrics
Calvo-Castro, Jesus; Guirguis, Amira; Samaras, Eleftherios; Zloh, Mire; Kirton, Stewart; Stair, Jacqueline (2018-09-12)A novel approach for the identification of New Psychoactive Substances (NPS) by means of Raman spectroscopy coupled with Principal Components Analysis (PCA) employing the largest dataset of NPS reference materials to date ... -
Detection rates of recurrent prostate cancer : 68Gallium (Ga)-labelled prostate-specific membrane antigen versus choline PET/CT scans. A systematic review
Moghul, Masood; Somani, Bhaskar; Lane, Tim; Vasdev, Nikhil; Chaplin, Brian; Peedell, Clive; KandaSwamy, Gokul Vignesh; Rai, Bhavan Prasad (2019-01-24)Background: The aim of this work was to assess the use of prostate-specific membrane antigen (PSMA)-labelled radiotracers in detecting the recurrence of prostate cancer. PSMA is thought to have higher detection rates when ... -
Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction
Kanji, Rahim; Gue, Ying X.; Farag, Mohamed F.; Spencer, Neil H.; Mutch, Nicola J.; Gorog, Diana A. (2022-11-14)Hypofibrinolysis is a recently-recognized risk factor for recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI), but the mechanistic determinants of this are not well understood. ... -
Determinants of Psychosocial Health in Psoriatic Patients: A Multinational Study
Lesner, Karolina; Reich, Adam; Szepietowski , Jacek C; Dalgard, Florence; Finlay, Andrew Y.; Kupfer, Joerg; Gieler, Uwe; Salek, Mir-Saeed Shayegan (2017-11-01)There are limited data on the differences in the impact of psoriasis between various countries with respect to quality of life (QoL). The aim of this study was to explore the psychosocial health of patients with psoriasis ... -
Determination of Cu2+ ions release rate from antimicrobial copper bearing stainless steel by joint analysis using ICP-OES and XPS
Ren, Ling; Chong, J.; Loya, Adil; Kang, Q.; Stair, Jacqueline; Nan, L.; Ren, Guogang (2015-08-30)Antibacterial Cu bearing stainless steels (CuSS) have been developed recently and their performance has attracted significant attention widely in biomedical, healthcare and environmental facilities in cross-disciplines. ... -
Developing an Intervention to Implement Electronic Patient-Reported Outcomes in Renal Services in the UK
Van Der Veer, Sabine N; Ercia, Angelo; Caskey, Fergus J; Farrington, Ken; Jury, Francine; Rees, Michael; Whitlock, Tim; Knowles, Sarah (IOS Press, 2020-06-16)Routinely collecting and using electronic patient-reported outcome (ePRO) data in clinical practice can improve patients' experience and outcomes, but implementing this at scale has proved challenging. As part of the ... -
The development and validation of a disease-specific quality of life measure in hyperhidrosis : the Hyperhidrosis Quality of Life Index (HidroQOL©)
Kamudoni, P; Mueller, B; Salek, M S (2015-04)PURPOSE: To develop and validate a new disease-specific quality of life measure in hyperhidrosis for use in both routine clinical practice and clinical research. METHODS: Interviews and focus group discussions with ... -
The Development and Validation of a Generic Instrument, QoDoS, for Assessing the Quality of Decision Making.
Donelan, R; Walker, Stuart; Salek, Mir-Saeed Shayegan (2016-07-13)Introduction: The impact of decision-making during the development and the regulatory review of medicines greatly influences the delivery of new medicinal products. Currently, there is no generic instrument that can be ... -
Development and validation of a questionnaire to measure moral distress in community pharmacists
Astbury, Jayne L; Gallagher, Cathal T (2017-02-01)Background Pharmacists work within a highly-regulated occupational sphere, and are bound by strict legal frameworks and codes of professional conduct. This regulatory environment creates the potential for moral distress ... -
Development of a Consumer Reported Outcome Measure for Personal Care Products : The Rationale
Falcone, Robert; Umaru, Nikkie; michniak-kohn, Bozena; Salek, Sam (2024-01-30)Background: Cosmetic products are one of the fastest-growing segments of personal care products in the United States. One of the critical elements in the sales and growth of cosmetics is leveraging claims. Unlike pharmaceuticals ... -
Development of a Novel Hematological Malignancy Specific Patient-Reported Outcome Measure (HM-PRO) : Content Validity
Goswami, Pushpendra; Oliva, Esther; Ionova, Tatyana; Else, R; Kell, J; Fielding, AK; Jennings, DM; Karakantza , M; Al-Ismail, S; Collins, GP; McConnell , S; Langton, Catherine; Salek, Sam (2020-03-05)Background: The quality of life of patients at all stages of hematological malignancy is greatly affected by the disease and its treatment. There is a wide range of health-related quality of life (HRQoL) issues important ... -
Development of a novel risk score to predict mortality in patients admitted to hospital with COVID-19
Gue, Ying X.; Tennyson, Maria; Gao, Jovia; Ren, Shuhui; Kanji, Rahim; Gorog, Diana A. (2020-12-07)Patients hospitalised with COVID-19 have a high mortality. Identification of patients at increased risk of adverse outcome would be important, to allow closer observation and earlier medical intervention for those at risk, ...