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Browsing by Author "Centre for Research in Mechanisms of Disease and Drug Discovery"
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MK-801 interaction with the 5-HT transporter : A real-time study in brain slices using fast cyclic voltammetry
Iravani, Mahmoud M.; Muscat, R.; Kruk, Z. L. (1999-06-01)The effects of a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine ((+)-MK-801) and a competitive NMDA antagonist, (+/-)-3-2-carboxypiperazin-4-yl-propyl-1-phosphonic acid (CPP) were compared in ... -
Model of a Putative Pore : The Pentameric -Helical Bundle of SARS Coronavirus E Protein in Lipid Bilayers
Torres, J.; Parthasarathy, K.; Lin, X.; Saravanan, R.; Kukol, A.; Liu, D.X. (2006) -
A modified MPTP treatment regime produces reproducible partial nigrostriatal lesions in common marmosets
Iravani, Mahmoud M.; Syed, E.; Jackson, M. J.; Johnston, L. C.; Smith, L. A.; Jenner, P. (2005-02)Standard MPTP treatment regimens in primates result in > 85% destruction of nigral dopaminergic neurons and the onset of marked motor deficits that respond to known symptomatic treatments for Parkinson's disease (PD). The ... -
Modifying the Properties of Thermogelling Poloxamer 407 Solutions through Covalent Modification and the Use of Polymer Additives
Abou Shamat, Mohamad; Calvo-Castro, Jesus; Stair, Jacqueline; Cook, Michael (2019-07-22)Thermoresponsive polymers that undergo sol–gel transition in a physiological temperature range have applications in biomedical science. Poloxamer 407 (P407) is commonly used as thermogelling material and has been approved ... -
Modulation of calcium-binding proteins expression and cisplatin chemosensitivity by calcium chelation in human breast cancer MCF-7 cells
Hodeify, Rawad; Siddiqui, Shoib Sarwar; Matar, Rachel; Vazhappilly, Cijo George; Merheb, Maxime; Al Zouabi, Hussain; Marton, John (2021-01-22)Cisplatin (CDDP) is currently one of the most effective FDA-approved treatments for breast cancer. Previous studies have shown that CDDP-induced cell death in human breast cancer (MCF-7) cells is associated with disruption ... -
Molecular basis for DarT ADP-ribosylation of a DNA base
Schuller, Marion; Butler, Rachel; Ariza, Antonio; Tromans-Coia, Callum; Jankevicius, Gytis; Claridge, Tim; Kendall, Sharon; Goh, Shan; Stewart, Graham; Ahel, Ivan (2021-08-18)ADP-ribosyltransferases use NAD+ to catalyse substrate ADP-ribosylation1, and thereby regulate cellular pathways or contribute to toxin-mediated pathogenicity of bacteria2–4. Reversible ADP-ribosylation has traditionally ... -
Molecular data reveal a cryptic species within the Culex pipiens mosquito complex
Dumas, Emilie; Atyame, Célestine M.; Malcolm, Colin A.; Le Goff, Gilbert; Unal, Sandra; Makoundou, Patrick; Pasteur, Nicole; Weill, Mylène; Duron, Olivier (2016-12-01)The Culex pipiens mosquito complex is a group of evolutionarily closely related species including the common house mosquito, Cx. pipiens, and the southern house mosquito, Cx. quinquefasciatus, which both are infected by ... -
A molecular dynamic investigation of viscosity and diffusion coefficient of nanoclusters in hydrocarbon fluids
Loya, Adil; Stair, Jacqueline L.; Jafri, Ali R.; Yang, Ke; Ren, Guogang (2015-03)Straight chain alkanes modified by metal oxide nanoclusters have gained wide recognition in applications in tribology, energy and thermal storage. This paper investigates the system’s rheological properties and diffusion ... -
Molecular dynamics simulation on surface modification of quantum scaled CuO nano-clusters to support their experimental studies
Loya, Adil; Stair, Jacqueline; Uddin, Farid; Ren, Guogang (2022-10-05)Interest in nanoparticle modification using functional chemicals has increased rapidly, as it allows more freedom of physiochemical tuning of the nanoparticle’s surface into biomedically oriented and designated properties. ... -
Molecular Engines, Therapeutic Targets, and Challenges in Pediatric Brain Tumors: A Special Emphasis on Hydrogen Sulfide and RNA-Based Nano-Delivery
Fahmy, Sherif Ashraf; Dawoud, Alyaa; Zeinelabdeen, Yousra Ahmed; Kiriacos, Caroline Joseph; Daniel, Kerolos Ashraf; Eltahtawy, Omar; Abdelhalim, Miriam Mokhtar; Braoudaki, Maria; Youness, Rana A. (2022-10-26)Pediatric primary brain tumors represent a real challenge in the oncology arena. Besides the psychosocial burden, brain tumors are considered one of the most difficult-to-treat malignancies due to their sophisticated ... -
The molecular epidemiology of tuberculosis in inner London
Hayward, A.C.; Goss, S.; Dobniewski, F.; Saunders, N.; Shaw, R.J.; Goyal, Madhu; Swan, A.; Uttley, A.; Pozniak, A.; Grace-Parker, J.; Watson, J.M. (2002) -
Molecular modeling of influenza A virus proteins
Patel, Hershna; Rapley, Ralph; Kukol, Andreas (2015-12-08) -
Molecular Modeling of Proteins
Kukol, A.; School of Life and Medical Sciences; Biosciences Research Group; Centre for Research in Mechanisms of Disease and Drug Discovery; Department of Clinical, Pharmaceutical and Biological Science; Centre for Future Societies Research (Springer Nature, 2015-01-01) -
Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesia
Zeng, Bai-Yun; Iravani, Mahmoud M.; Jackson, Michael J.; Rose, Sarah; Parent, Andre; Jenner, Peter (2010-12)Hyperinnervation of the striatum by serotoninergic (5-HT) terminals occurs after destruction of the dopaminergic nigro-striatal pathway. Recent studies have suggested that non-physiological release of dopamine (DA) formed ... -
MPTP treatment of common marmosets impairs proteasomal enzyme activity and decreases expression of structural and regulatory elements of the 26S proteasome
Zeng, Bai-Yun; Iravani, Mahmoud M.; Lin, S. T.; Irifune, M.; Kuoppamaki, M.; Al-Barghouthy, G.; Smith, L.; Jackson, M. J.; Rose, S.; Medhurst, A.D.; Jenner, P. (2006-04)Dysfunction of the ubiquitin-proteasome system occurs in the substantia nigra (SN) in Parkinson's disease (PD). However, it is unknown whether this is a primary cause or a secondary consequence of other components of the ... -
The mRNA content of plasma extracellular vesicles provides a window into the brain during cerebral malaria disease progression
Abdi, Abdirahman; Mwikali, Kioko; Mwangi, Shaban; Pance, Alena; Ochola-Oyier, Lynette; Kariuki, Symon; Newton, Charles; Bejon, Philip; Rayner, Julian (2023-09-28)The impact of cerebral malaria on the transcriptional profiles of cerebral tissue is difficult to study using non-invasive approaches. We isolated plasma extracellular vesicles (EVs) from patients with cerebral malaria and ... -
Multivariate analytical approaches to identify key molecular properties of vehicles, permeants and membranes that affect permeation through membranes
Najib, Omaima N.; Kirton, Stewart B.; Martin, Gary P.; Botha, Michelle J.; Sallam, Al Sayed; Murnane, Darragh (2020-10-31)There has been considerable recent interest in employing computer models to investigate the relationship between the structure of a molecule and its dermal penetration. Molecular permeation across the epidermis has previously ... -
MYCN in Neuroblastoma: “Old Wine into New Wineskins”
Braoudaki, Maria; Hatziagapiou, Kyriaki; Zaravinos, Apostolos; Lambrou, George I. (2021-10-29)MYCN Proto-Oncogene, BHLH Transcription Factor (MYCN) has been one of the most studied genes in neuroblastoma. It is known for its oncogenetic mechanisms, as well as its role in the prognosis of the disease and it is ... -
Native CB1 receptor affinity, intrinsic activity and accumbens shell dopamine stimulant properties of third generation SPICE/K2 cannabinoids : BB-22, 5F-PB-22, 5F-AKB-48 and STS-135
De Luca, Maria Antonietta; Castelli, M. Paola; Loi, Barbara; Porcu, Alessandra; Martorelli, Mariella; Miliano, Cristina; Kellett, Kathryn; Davidson, Colin; Stair, Jacqueline L.; Schifano, Fabrizio; Di Chiara, Gaetano (2016-06-01)In order to investigate the in vivo dopamine (DA) stimulant properties of selected 3rd generation Spice/K2 cannabinoids, BB-22, 5F-PB-22, 5F-AKB-48 and STS-135, their in vitro affinity and agonist potency at native rat and ... -
Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis
Riessland, Markus; Kaczmarek, Anna; Schneider, Svenja; Swoboda, Kathryn J; Löhr, Heiko; Bradler, Cathleen; Grysko, Vanessa; Dimitriadi, Maria; Hosseinibarkooie, Seyyedmohsen; Torres-Benito, Laura; Peters, Miriam; Upadhyay, Aaradhita; Biglari, Nasim; Kröber, Sandra; Hölker, Irmgard; Garbes, Lutz; Gilissen, Christian; Hoischen, Alexander; Nürnberg, Gudrun; Nürnberg, Peter; Walter, Michael; Rigo, Frank; Bennett, C Frank; Kye, Min Jeong; Hart, Anne C; Hammerschmidt, Matthias; Kloppenburg, Peter; Wirth, Brunhilde (2017-02-02)Homozygous SMN1 loss causes spinal muscular atrophy (SMA), the most common lethal genetic childhood motor neuron disease. SMN1 encodes SMN, a ubiquitous housekeeping protein, which makes the primarily motor neuron-specific ...