- UHRA Home
- Browsing by Author
Browsing by Author "Centre for Research in Mechanisms of Disease and Drug Discovery"
Now showing items 41-60 of 435
-
Characterisation of the interaction of the C-terminus of the dopamine D2 receptor with neuronal calcium sensor-1
Lian, Lu-Yun; Pandalaneni, Sravan R.; Patel, Pryank; McCue, Hannah V.; Haynes, Lee P.; Burgoyne, Robert D. (2011-11-16)NCS-1 is a member of the neuronal calcium sensor (NCS) family of EF-hand Ca(2+) binding proteins which has been implicated in several physiological functions including regulation of neurotransmitter release, membrane ... -
Characterization of imidazoline receptors by radioligand binding
Hudson, A.L.; Lione, Lisa (Humana Press, 1999) -
Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation
Lione, Lisa; Carter, R. J.; Humby, T.; Mangiarini, L.; Mahal, A.; Bates, G. P.; Dunnett, S.B.; Morton, A. J. (1999-04-15)Transgenic mice expressing exon 1 of the human Huntington's disease (HD) gene carrying a 141-157 CAG repeat (line R6/2) develop a progressive neurological phenotype with motor symptoms resembling those seen in HD. We have ... -
Characterization of the sporulation initiation pathway of Clostridium difficile and its role in toxin production
Underwood, Sarah; Guan, Shuang; Vijayasubhash, Vinod; Baines, Simon D.; Graham, Luke; Lewis, Richard J.; Wilcox, M. H.; Stephenson, Keith (2009)Clostridium difficile is responsible for significant mortality and morbidity in the hospitalized elderly. C. difficile spores are infectious and are a major factor contributing to nosocomial transmission. The Spo0A response ... -
Chemokines and chemokine receptors in colorectal cancer; multifarious roles and clinical impact
Braoudaki, Maria; Ahmad, Mohammed Saqif; Mustafov, Denis; Seriah, Sara; Siddiqui, Mohammad Naseem; Siddiqui, Shoib (2022-10-13)Colorectal cancer (CRC) is considered the second cause of cancer death worldwide. The early diagnosis plays a key role in patient prognosis and subsequently overall survival. Similar to several types of cancer, colorectal ... -
Circular RNAs: New layer of complexity evading breast cancer heterogeneity
Dawoud, Alyaa; Zakaria, Zeina Ihab; Rashwan, Hannah Hisham; Braoudaki, Maria; Youness, Rana A. (2023-03-30)Advances in high-throughput sequencing techniques and bioinformatic analysis have refuted the "junk" RNA hypothesis that was claimed against non-coding RNAs (ncRNAs). Circular RNAs (circRNAs); a class of single-stranded ... -
Circulation of Highly Drug-Resistant Clostridium difficile Ribotypes 027 and 001 in Two Tertiary-Care Hospitals in Mexico
Adrian Martinez-Melendez, Adrian; Tijerina-Rodrıguez, Laura; Morfin-Otero, Rayo; Camacho-Ortiz, Adrian; Villarreal-Trevino, Licet; Sanchez-Alanıs, Hugo; Rodrıguez-Noriega, Eduardo; Baines, Simon; Flores-Trevino, Samantha; Maldonado-Garza, Hector Jesus; Garza-Gonzalez, Elvira (2018-05-01)OBJECTIVE: To assess drug susceptibility and characterize Clostridium difficile ribotypes in isolates from two tertiary-care hospitals in Mexico. METHODS: Isolates were evaluated for genotyping, antimicrobial susceptibility ... -
Co-Deregulated miRNA Signatures in Childhood Central Nervous System Tumors: In Search for Common Tumor miRNA-Related Mechanics
Lambrou, George I.; Zaravinos, Apostolos; Braoudaki, Maria (2021-06-17)Despite extensive experimentation on pediatric tumors of the central nervous system (CNS), related to both prognosis, diagnosis and treatment, the understanding of pathogenesis and etiology of the disease remains scarce. ... -
Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery
Perez Diaz, Noelia; Lione, Lisa; Hutter, Victoria; Mackenzie, Louise Susan (MDPI Multidisciplinary Digital Publishing Institute, 2022-05-01)Peroxisome proliferator activated receptor beta/delta (PPARβ/δ) is a nuclear receptor ubiquitously expressed in cells, whose signaling controls inflammation. There are large discrepancies in understanding the complex role ... -
Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery
Perez Diaz, Noelia; Lione, Lisa; Hutter, Victoria; Mackenzie, Louise Susan (2021-03-19)Peroxisome proliferator activated receptor beta/delta (PPARβ/δ) is a nuclear receptor ubiquitously expressed in cells, whose signaling controls inflammation. There are large discrepan-cies in understanding the complex role ... -
Comparative modelling of cytochromes P450
Kirton, S. B.; Baxter, C. A.; Sutcliffe, M. J. (2002-03-31)The superfamily of enzymes known as the cytochromes P450 (P450s) comprises a wide-ranging class of proteins with diverse functions. They are known, amongst other things, to be involved in the hormonal regulation of metabolism ... -
Comparative modelling of the kinase IKK-beta and prediction of inhibitors
Kalia, Munishikha; Varsani, Poonam; Kukol, Andreas (2019-10-08) -
A Comparison of Different Approaches for Characterizing Microplastics in Selected Personal Care Products
Renner, Kofi O; Foster, Helen A; Routledge, Edwin J; Scrimshaw, Mark D (2021-04-05)Any uncertainty in determining numbers of microplastics in the environment may be barrier to assessing their impact and may stem from various aspects of methodologies used to quantify them. This paper undertakes a comparison ... -
A comparison of novel N(G),N(G)-disubstituted arginines on recombinant dimethylarginine dimethylaminohydrolase-1 activity and nitrite production in RAW264.7 macrophages
Morfill, Corinne; Rossiter, Sharon; Smith, Caroline (2012) -
Comparison of oritavancin versus vancomycin as treatments for clindamycin-induced Clostridium difficile PCR ribotype 027 infection in a human gut model
Baines, Simon D.; O'Connor, Rachael; Saxton, Katie; Freeman, Jane; Wilcox, Mark H. (2008)To compare the efficacy of oritavancin and vancomycin in the treatment of Clostridium difficile infection (CDI) using an in vitro human gut model. -
Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections
McFarland, Lynne Vernice; Ozen, Metehan; Dinleyici, Ener Cagri; Goh, Shan (2016-03-21)Antibiotic-associated diarrhea (AAD) and Clostridium difficile infections (CDI) have been well studied for adult cases, but not as well in the pediatric population. Whether the disease process or response to treatments ... -
Comparison of planktonic and biofilm-associated communities of Clostridium difficile and indigenous gut microbiota in a triple-stage chemostat gut model
Crowther, Grace S.; Chilton, Caroline H.; Todhunter, Sharie L.; Nicholson, Scott; Freeman, Jane; Baines, Simon D.; Wilcox, Mark H. (2014-04-30)BACKGROUND: Biofilms are characteristic of some chronic or recurrent infections and this mode of growth tends to reduce treatment efficacy. Clostridium difficile infection (CDI) is associated with a high rate of recurrent ... -
Comparison of somatodendritic and axon terminal dopamine release in the ventral tegmental area and the nucleus accumbens
Iravani, Mahmoud M.; Muscat, R.; Kruk, Z. L. (1996-02)Fast cyclic voltammetry at a carbon fibre microelectrode was used to measure dopamine release following electrical or chemical stimulation in rat brain slices incorporating either the ventral tegmental area or the core ... -
Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection
Freeman, Jane; Baines, Simon D.; Jabes, Daniela; Wilcox, Mark H. (2005-09)Treatment of Clostridium difficile infection (CDI) is limited primarily to either metronidazole or vancomycin. We compared vancomycin and a novel glycolipodepsipeptide, ramoplanin, in both hamster and in vitro gut models ... -
Compounds for the treatment of pain : WO2004/078183
School of Life and Medical Sciences; TRP Ion channels; Centre for Research in Mechanisms of Disease and Drug Discovery; Department of Clinical, Pharmaceutical and Biological Science; Basic and Clinical Science Unit; Centre for Health Services and Clinical Research; Lione, Lisa; Richardson, P.J.; Lee, K. (2007)