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Browsing by Author "Centre for Research in Mechanisms of Disease and Drug Discovery"
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Concurrent growth rate and transcript analyses reveal essential gene stringency in Escherichia coli
Goh, Shan; Boberek, Jaroslaw M; Nakashima, Nobutaka; Stach, Jem; Good, Liam (2009-06-26)BACKGROUND: Genes essential for bacterial growth are of particular scientific interest. Many putative essential genes have been identified or predicted in several species, however, little is known about gene expression ... -
Conformational Flexibility of the Peptide Hormone Ghrelin in Solution and Lipid Membrane Bound: A Molecular Dynamics Study
Beevers, A.J.; Kukol, A. (2006)Human ghrelin is a peptide hormone of 28 aminoacid residues, in which the Ser3 is modified by an octanoyl group. Ghrelin has a major role in the energy metabolism of the human body stimulating growth hormone release as ... -
Consensus virtual screening approaches to predict protein ligands
Kukol, A. (2011)In order to exploit the advantages of receptor-based virtual screening, namely time/cost saving and specificity, it is important to rely on algorithms that predict a high number of active ligands at the top ranks of a small ... -
Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction
Stockwell, K. A.; Scheller, D.; Rose, S.; Jackson, M. J.; Tayarani-Binazir, K.; Iravani, Mahmoud M.; Smith, L. A.; Olanow, C. W.; Jenner, P. (2009-10)Rotigotine is a novel, non-ergoline dopamine D-3/D-2/D-1-receptor agonist for the treatment of Parkinson's disease that can be Continuously delivered by the transdermal route to provide stable plasma levels. Continuous ... -
Continuous delivery of ropinirole reverses motor deficits without dyskinesia induction in MPTP-treated common marmosets
Stockwell, K. A.; Virley, D. J.; Perren, M.; Iravani, Mahmoud M.; Jackson, M. J.; Rose, S.; Jenner, P. (2008-05)L-DOPA treatment of Parkinson's disease induces a high incidence of motor complications, notably dyskinesia. Longer acting dopamine agonists, e.g. ropinirole, are thought to produce more continuous dopaminergic stimulation ... -
Continuous rotigotine administration reduces dyskinesia resulting from pulsatile treatment with rotigotine or L-DOPA in MPTP-treated common marmosets
Stockwell, K. A.; Scheller, D. K. A.; Smith, L. A.; Rose, S.; Iravani, Mahmoud M.; Jackson, M. J.; Jenner, P. (2010-01)We previously showed that continuous infusion of rotigotine resulted in less dyskinesia than repeated pulsatile rotigotine administration or repeated oral administration Of L-DOPA in MPTP-treated marmosets. Now we investigate ... -
Continuous subcutaneous infusion of pramipexole protects against lipopolysaccharide-induced dopaminergic cell death without affecting the inflammatory response
Iravani, Mahmoud M.; Sadeghian, Mona; Leung, Clement C. M.; Tel, Banu C.; Rose, Sarah; Schapira, Anthony H.; Jenner, Peter (2008-08)The D2/D3 dopamine receptor agonist pramipexole, protects against toxin-induced dopaminergic neuronal destruction but its mechanism of action is unknown. Inflammation following glial cell activation contributes to cell ... -
Continuous vs pulsatile administration of rotigotine in rat and monkey models of Parkinson's disease: A comparison
Scheller, D. K. A.; Schmidt, W. J.; Jackson, M. J.; Ruess, U.; Stockwell, K.; Heindl, M.; Iravani, Mahmoud M.; Tayarani-Binazir, K.; Rose, S.; Jenner, P. (2008) -
Contractile dysfunction and nitrergic dysregulation in small intestine of a primate model of Parkinson’s disease : contractile dysfunction in MPTP-treated primate ileum
Coletto, E; Dolan, John S; Pritchard, Sara; Gant, Alex; Hikima, Atsuko; Jackson, Michael J; Benham, Christopher; Chaudhuri, K. Ray; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud (2019-06-10)Bowel dysfunction is a common non-motor symptom in Parkinson's disease (PD). The main contractile neurotransmitter in the GI tract is acetylcholine (ACh), while nitric oxide (NO) causes the relaxation of smooth muscle in ... -
Copper (II) mediated arylation with aryl boronic acids for the N-derivatization of pyrazole libraries
Rossiter, S.; Woo, C.K.; Hartzoulakis, B.; Wishart, G.; Stanyer, L.; Labadie, J.W.; Selwood, D.L. (2004)A N-derivatized 3-dimethylaminopropyloxypyrazole library was prepared using solution-phase parallel synthesis. The library was designed using physicochemical constraints designed to remove non-membrane-permeable molecules. ... -
Cytokine mRNA expression in cattle infected with different dosages of Mycobacterium bovis
Boddu-Jasmine, H.C.; Witchell, J.; Vordermeier, M.; Wangoo, A.; Goyal, M. (2008)Cytokine mRNA expression of pro-inflammatory cytokines, i.e., interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α) and anti-inflammatory cytokines, i.e., interleukin-4 (IL-4), interleukin-10 (IL-10) was quantified ... -
Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and Metastasis
Mustafov, Denis; Karteris, Emmanouil; Braoudaki, Maria (2023-01-04)Glioblastoma multiforme (GBM) is a highly heterogenic and malignant brain tumour with a median survival of 15 months. The initial identification of primary glioblastomas is often challenging. Coronin 1C (CORO1C) is a key ... -
Decreased function of survival motor neuron protein impairs endocytic pathways
Dimitriadi, Maria; Derdowski, Aaron; Kalloo, Geetika; Maginnis, Melissa S; O'Hern, Patrick; Bliska, Bryn; Sorkaç, Altar; Nguyen, Ken C Q; Cook, Steven J; Poulogiannis, George; Atwood, Walter J; Hall, David H; Hart, Anne C (2016-07-26)Spinal muscular atrophy (SMA) is caused by depletion of the ubiquitously expressed survival motor neuron (SMN) protein, with 1 in 40 Caucasians being heterozygous for a disease allele. SMN is critical for the assembly of ... -
Deletions of Chromosome 7q Affect Nuclear Organization and HLXB9Gene Expression in Hematological Disorders.
Federico, Concetta; Owoka, Temitayo; Ragusa, Denise; Sturiale, Valentina; Caponnetto, Domenica; Leotta, Claudia Giovanna; Bruno, Francesca; Foster, Helen; Rigamonti, Silvia; Giudici, Giovanni; Cazzaniga, Giovanni; Bridger, Joanna; Sisu, Cristina; Saccone, Salvatore; Tosi, Sabrina (2019-04-25)The radial spatial positioning of individual gene loci within interphase nuclei has been associated with up- and downregulation of their expression. In cancer, the genome organization may become disturbed due to chromosomal ... -
Demethylation of 2,4-dimethoxquinolines: the synthesis of atanine
Jones, K.; Roset, X.; Rossiter, S.; Whitfield, P.J. (2003) -
Deoxycholic acid activates colonic afferent nerves via 5-HT3 receptor dependent and independent mechanisms
Yu, Yang; Villalobos- Hernandez, Egina; Pradhananga, Sabindra; Baker, Corey; Keating, Christopher; Grundy, David; Lomax, Allan; Reed, David (2019-09-01)Increased bile acids in the colon can evoke increased epithelial secretion resulting in diarrhea, but little is known about whether colonic bile acids contribute to abdominal pain. This study aimed to investigate the ... -
Design and characterisation of a novel in vitro skin diffusion cell system for assessing mass casualty decontamination systems
Matar, H.; Larner, J.; Kansagra, S.; Atkinson, K. L.; Skamarauskas, J. T.; Amlot, R.; Chilcott, Robert (2014-06-30)The efficient removal of contaminants from the outer surfaces of the body can provide an effective means of reducing adverse health effects associated with incidents involving the accidental or deliberate release of hazardous ... -
Design, Synthesis and Antimicrobial Evaluation of the in vitro Efficacy of Novel Diketones
Garikipati, Rajesh; Mohammed, Olufunmilayo; Rossiter, Sharon; Baines, Simon; Bassin, Jatinder; Goyal, Madhu (2015-11-26)A series of novel diketones were designed and synthesised in an attempt to develop potent antimicrobial agents. Their structures were confirmed by spectroscopic techniques i.e. 1H and 13C-NMR, IR and LC-MS. The minimum ... -
A Design-of-Experiments Approach to Developing Thermoresponsive Gelators From Complex Polymer Mixtures
Kirton, Stewart; Stair, Jacqueline; Abou Shamat, Mohamad; Calvo-Castro, Jesus; Cook, Michael T. (2020-10-13)This study investigated the effects of additives on the properties of poloxamer (P) 407 thermogels, employing a design-of-experiments (DoE) approach. P407 is a thermoresponsive triblock copolymer that exhibits a solution ...