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Browsing by Author "Centre for Research in Mechanisms of Disease and Drug Discovery"
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Designer Benzodiazepines’ Activity on Opioid Receptors: A Docking Study
Catalani, Valeria; Botha, Michelle; Corkery, John Martin; Guirguis, Amira; Vento, Alessandro; Schifano, Fabrizio (2022-09-22)BACKGROUND: Previous studies have reported that benzodiazepines (BZDs) seem to enhance euphoric and reinforcing properties of opioids in opioid users so that a direct effect on opioid receptors has been postulated, together ... -
Detection of Newly Emerging Psychoactive Substances Using Raman Spectroscopy and Chemometrics
Calvo-Castro, Jesus; Guirguis, Amira; Samaras, Eleftherios; Zloh, Mire; Kirton, Stewart; Stair, Jacqueline (2018-09-12)A novel approach for the identification of New Psychoactive Substances (NPS) by means of Raman spectroscopy coupled with Principal Components Analysis (PCA) employing the largest dataset of NPS reference materials to date ... -
Determination of Cu2+ ions release rate from antimicrobial copper bearing stainless steel by joint analysis using ICP-OES and XPS
Ren, Ling; Chong, J.; Loya, Adil; Kang, Q.; Stair, Jacqueline; Nan, L.; Ren, Guogang (2015-08-30)Antibacterial Cu bearing stainless steels (CuSS) have been developed recently and their performance has attracted significant attention widely in biomedical, healthcare and environmental facilities in cross-disciplines. ... -
Developing microfluidic platforms for rapid identification of new targets for neurodegenerative disorders
Pacheco Torres, Paloma; Kaye, Richard; Johnston, Ian; Dimitriadi, Maria; Tan, Christabel (2023-10-19) -
Development and validation of a chemostat gut model to study both planktonic and biofilm modes of growth of Clostridium difficile and human microbiota
Crowther, Grace S.; Chilton, Caroline H.; Todhunter, Sharie L.; Nicholson, Scott; Freeman, Jane; Baines, Simon D.; Wilcox, Mark H. (2014-02-06)The human gastrointestinal tract harbours a complex microbial community which exist in planktonic and sessile form. The degree to which composition and function of faecal and mucosal microbiota differ remains unclear. We ... -
Development of a Potential Yeast-Based Vaccine Platform for Theileria parva Infection in Cattle
Goh, Shan; Kolakowski, Jeannine; Holder, Angela; Pfuhl, Mark; Ngugi, Daniel; Ballingall, Keith; Tombacz, Kata; Werling, Dirk (2021-07-08)East Coast Fever (ECF), caused by the tick-borne apicomplexan parasite Theileria parva, remains one of the most important livestock diseases in sub-Saharan Africa with more than 1 million cattle dying from infection every ... -
Development of lux-based biosensors in P. aeruginosa ATCC 9027 for preservative efficacy testing
Shah, Niksha; Kukol, Andreas; Naseby, David (2012) -
The development of species-specific antisense peptide nucleic acid method for the treatment and detection of viable Salmonella
Adebowale, Oluwawemimo; Goh, Shan; Good, Liam (2020-06)Genotypic based detection methods using specific target sites in the pathogen genome can complement phenotypic identification. We report the development of species-specific antisense peptide nucleic acid (PNA) combined ... -
Diabetes confers in vitro calcific potential on serum which associates with in-vivo vascular calcification
Patidar, Ashish; Singh, Dhruv; Thakur, Shori; Winocour, Peter; Farrington, Kenneth; Baydoun, Anwar (2017-05-09)Although vascular calcification (VC) is prevalent in Type 2 diabetes mellitus (T2DM), underlying mechanisms remain unclear. Neither is it known whether T2DM confers calcific potential (CP) on serum, enabling it to induce ... -
Diabetic dyslipidaemia is associated with alterations in eNOS, caveolin-1 and endothelial dysfunction in streptozotocin treated rats
Shamsaldeen, Yousif; Ugur, Rosemary; Benham, Christopher; Lione, Lisa (2018-07-01)Background: Diabetes is a complex progressive disease characterised by chronic hyperglycaemia and dyslipidaemia associated with endothelial dysfunction. Oxidised LDL (Ox-LDL) is elevated in diabetes and may contribute to ... -
Diabetic dyslipidaemia is associated with alterations in eNOS, caveolin-1 and endothelial dysfunction in streptozotocin treated rats : Supplement to Diabetes Metab Res Rev. 34(5):e2995.
Lione, Lisa; Benham, Christopher; Shamsaldeen, Yousif (Biomedical Advances, 2019-08-13)Background: Diabetes is a complex progressive disease characterised by chronic hyperglycaemia and dyslipidaemia associated with endothelial dysfunction. Oxidised LDL (Ox-LDL) is elevated in diabetes and may contribute to ... -
Differential and Common Signatures of miRNA Expression and Methylation in Childhood Central Nervous System Malignancies: An Experimental and Computational Approach
Lambrou, George I.; Poulou, Myrto; Giannikou, Krinio; Themistocleous, Marios; Zaravinos, Apostolos; Braoudaki, Maria (2021-10-31)Epigenetic modifications are considered of utmost significance for tumor ontogenesis and progression. Especially, it has been found that miRNA expression, as well as DNA methylation plays a significant role in central ... -
Differential dose–response effect of cyclosporine A in regulating apoptosis and autophagy markers in MCF-7 cells
Siddiqui, Shoib; Hodeify, Rawad; Mathew, Shimy; Alsawaf, Seba; Alghfeli, Anood; Matar, Rachel; Merheb, Maxime; Marton, John; Al Zouabi, Hussain AbdulKarim; Muthuirulandi Sethuvel, Dhiviya Prabaa; Devanga Ragupathi, Naveen Kumar; Vazhappilly , Cijo George (2023-05-19)Cyclosporine A (CsA) is an immunosuppressant primarily used at a higher dosage in transplant medicine and autoimmune diseases with a higher success rate. At lower doses, CsA exhibits immunomodulatory properties. CsA has ... -
Differential modulation of motor neurons that innervate the same muscle but use different excitatory transmitters in Aplysia
Keating, Christopher; Lloyd, Philip (1999-10)The medial portion of intrinsic buccal muscle 3 (I3m) is innervated by two excitatory motor neurons, B3 and B9. B3 uses glutamate as its fast transmitter and expresses the neuropeptide FMRFamide, whereas B9 uses acetylcholine ... -
Differential release of dopamine by nitric oxide in subregions of rat caudate putamen slices
Iravani, Mahmoud M.; Millar, J.; Kruk, Z. L. (1998-11)Fast cyclic voltammetry was used to measure NO and dopamine (DA) simultaneously in rat caudate putamen (CPu) slices. Analysis of electrochemical signals obtained from mixtures of DA and NO showed that subtraction of either ... -
Differential sensitivities of rat striatal D-2 Dopamine autoreceptor sites
Iravani, Mahmoud M.; Kruk, Z. L. (1992-10) -
Differential-effects of Nifedipine on nerve-mediated and noradrenaline-evoked contractions of rat anococcygeus muscle
Iravani, Mahmoud M.; Zar, M. A. (1993-11-30)In rat anococcygeus muscle the inhibitory effect of nifedipine (0.01. 0.1, 1.0 and 10 muM) was determined on adrenergic twitches in response to electrical field stimulation (trains of 4 pulses, 0.1 ms pulse duration. 10 ... -
Direct effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin or dopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulate, and the dorsal raphe nucleus slices
Iravani, Mahmoud M.; Asari, D.; Patel, J.; Wieczorek, W. J.; Kruk, Z. L. (2000-06-15)We examined the effects of pressure ejected 3,4-methylenedioxymethamphetamine (MDMA) from a micropipette on direct chemically stimulated release, and on electrically stimulated serotonin (5-HT) or dopamine (DA) release in ... -
Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis
Hartzoulakis, B.; Rossiter, S.; Gill, H.; Steinke, E.; Gane, P.J.; Hurtado-Guerrero, R.; Leiper, J.M.; Vallance, P.; Murray-Rust, J.; Selwood, D.L. (2007) -
Discovery of novel small molecule inhibitors of S100P, with in vitro anti-metastatic effects on pancreatic cancer cells
Camara, Ramatoulie; Ogbeni, Deborah; Gerstmann, Lisa; Ostovar, Mehrnoosh; Hurer, Ellie; Scott, Mark; Mahmoud, Nasir; Radon, Tomasz; Crnogorac-Jurcevic, Tatjana; Patel, Pryank; Mackenzie, Louise Susan; Chau, David; Kirton, Stewart; Rossiter, Sharon (2020-10-01)S100P, a calcium- binding protein, is known to advance tumor progression and metastasis in pancreatic and several other cancers. Herein is described the in silico identification of a putative binding pocket of S100P to ...