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Browsing by Author "Keating, Christopher"
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Translational potential of a mouse in-vitro bioassay in predicting gastrointestinal adverse drug reactions in phase 1 clinical trials
Keating, Christopher; Ewart, Lorna; Grundy, Luke; Valentin, Jean-Pierre; Grundy, David (2014-07)Background: Motility-related gastrointestinal adverse drug reactions (GADRs) such as diarrhoea and constipation are a common and deleterious feature associated with drug development. Novel biomarkers of GI function are ... -
TRPA1 Channel Activation Inhibits Motor Activity In The Mouse Colon
Hassan, Abdul-Azim; Sleet, Ben; Cousins, Zoe; Keating, Christopher (2020-05-27)There is a growing awareness of the role that TRP channels play in regulating sensory and motor functions in the gastrointestinal tract. In this study we used an in-vitro murine model of colonic peristaltic-like complexes ... -
The validation of an invitro colonic motility assay as a biomarker for gastrointestinal adverse drug reactions
Keating, Christopher; Ewart, Lornal; Gibbons, Stephen; Grundy, Luke; Valentin, Jean-Pierre; Grundy, David (2010-06)Motility-related gastrointestinal adverse drug reactions (GADRs), such as constipation and diarrhea, are some of the most frequently reported adverse events associated with the clinical development of new chemical entities, ... -
Whole-Genome Analysis of 60 G Protein-Coupled Receptors in Caenorhabditis elegans by Gene Knockout with RNAi
Keating, Christopher; Kriek, Neline; Daniels, Margaret; Ashcroft, Neville R.; Hopper, Neil A.; Siney, Elodie J.; Holden-Dye, Lindy; Burke, Julian F. (2003-09)G protein-coupled receptors (GPCRs) are the largest family of genes in animal genomes and represent more than 2% of genes in humans and C. elegans. These evolutionarily conserved seven-transmembrane proteins transduce a ...