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Browsing by Author "Adams, J. L."
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Effects of a novel lanosterol 14α-demethylase inhibitor on the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hep G2 cells
Mayer, R. J.; Adams, J. L.; Bossard, M. J.; Berkhout, Theo (1991-12-10)A 32-carboxylic acid derivative of lanosterol (SKF 104976) was found to be a potent inhibitor of lanosterol 14α-demethylase (14αDM). 14αDM activity in a Hep G2 cell extract was inhibited 50% by 2 nM SKF 104976. Exposure ...