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Browsing by Author "Almerico, Anna Maria"
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A definitive pharmacophore modelling study on CDK2 ATP pocket binders: tracing the path of new virtual high-throughput screenings
Tutone, Marco; Culletta, Giulia; Livecchi, Luca; Almerico, Anna Maria (2019-06-20)Cyclin Dependent Kinases-2 (CDK2) are members of serine/threonine protein kinases family. They play an important role in the regulation events of the eukaryotic cell division cycle, especially during the G1 to S phase ... -
Investigation on Quantitative Structure-Activity Relationships of 1,3,4 Oxadiazole Derivatives as Potential Telomerase Inhibitors
Tutone, Marco; Pecoraro, Beatrice; Almerico, Anna Maria (2018-07-23)A series of 1,3,4-oxadiazole derivatives with significant broad-spectrum anticancer activity against different cell lines, and demonstrated telomerase inhibition, was subjected to Quantitative Structure-Activity Relationships ... -
Predicting Skin Permeability by means of Computational Approaches : Reliability and Caveats in Pharmaceutical Studies
Pecoraro, Beatrice; Tutone, Marco; Hoffman, Ewelina; Hutter, Victoria; Almerico, Anna Maria; Traynor, Matthew (2019-05-28)The skin is the main barrier between the internal body environment and the external one. The characteristics of this barrier and its properties are able to modify and affect drug delivery and chemical toxicity parameters. ...