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Browsing by Author "Angiolillo, Dominick J."
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Antithrombotic therapy in diabetes: Which, when, and for how long?
Ajjan, RA; Kietsiriroje, N; Badimon, L; Gorog, Diana; Angiolillo, Dominick J.; Russel, D; Rocca, Bianca; Storey, Robert F. (2021-03-25)Cardiovascular disease remains the main cause of mortality in individuals with diabetes mellitus (DM) and also results in significant morbidity. Premature and more aggressive atherosclerotic disease, coupled with an enhanced ... -
The East Asian Paradox : An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease
Kim, Hyun Kuk; Tantry, Udaya S.; Smith, Sidney C.; Jeong, Myung Ho; Park, Seung Jung; Kim, Moo Hyun; Lim, Do Sun; Shin, Eun Seok; Park, Duk Woo; Huo, Yong; Chen, Shao Liang; Bo, Zheng; Goto, Shinya; Kimura, Takeshi; Yasuda, Satoshi; Chen, Wen Jone; Chan, Mark; Aradi, Daniel; Geisler, Tobias; Gorog, Diana A.; Sibbing, Dirk; Lip, Gregory Y.H.; Angiolillo, Dominick J.; Gurbel, Paul A.; Jeong, Young Hoon (2020-11-10)East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y 12receptor inhibitors (e.g., ticagrelor and prasugrel) and ... -
Inflammation and platelet reactivity during adjunctive colchicine versus aspirin in patients with acute coronary syndrome treated with potent P2Y12 inhibitor
Lee, Seung-Yul; Cho, Jae Young; Gorog, Diana A.; Angiolillo, Dominick J.; Yun, Kyeong Ho; Ahn, Jong-Hwa; Koh, Jin-Sin; Park, Yongwhi; Hwang, Seok-Jae; Hwang, Jin-Yong; Kim, Jin Won; Jang, Yangsoo; Jeong, Young-Hoon (2024-04-19)Background: In patients undergoing percutaneous coronary intervention (PCI), the use of anti-inflammatory therapy with colchicine is associated with a reduction of recurrent ischemic events. The mechanisms of such findings ... -
P2Y12 Inhibitor Monotherapy Combined With Colchicine Following PCI in ACS Patients: The MACT Pilot Study
Lee, Seung-Yul; Jeong, Young-Hoon; Ho Yun, Kyeong; Young Cho, Jae; Gorog, Diana; Angiolillo, Dominick J.; Jin Won, Kim; Jang, Yangsoo (2023-08-14)This proof-of-concept pilot trial investigated the feasibility of ticagrelor or prasugrel P2Y12 inhibitor monotherapy combined with colchicine immediately after PCI in ACS patients. The day after PCI, aspirin was replaced ... -
Pharmacodynamics, pharmacokinetics, and safety of single-dose subcutaneous administration of selatogrel, a novel P2Y12 receptor antagonist, in patients with chronic coronary syndromes
Storey, Robert F.; Gurbel, Paul A.; Berg, Jurrien ten; Bernaud, Corine; Dangas, George D.; Frenoux, Jean Marie; Gorog, Diana A.; Hmissi, Abdel; Kunadian, Vijay; James, Stefan K.; Tanguay, Jean Francois; Tran, Henry; Trenk, Dietmar; Ufer, Mike; van der Harst, Pim; Van't Hof, Arnoud W.J.; Angiolillo, Dominick J. (2020-09-01)Aims To study the pharmacodynamics and pharmacokinetics of selatogrel, a novel P2Y12 receptor antagonist for subcutaneous administration, in patients with chronic coronary syndromes (CCS). Methods In this double-blind, ... -
Results of an international crowdsourcing survey on the treatment of non-ST segment elevation ACS patients at high-bleeding risk undergoing percutaneous intervention
Deepak, Bhatt; Kaski, Juan Carlos; Delaney, Sean; Alasnag, Mirvat; Andreotti, Felicita; Angiolillo, Dominick J.; Ferro, Albert; Gorog, Diana; Lorenzatti, Alberto; Mamas, Mamas A.; McNeil, John; Nicolau, José C; Steg, Gabriel Philippe; Tamargo, Juan; Doreen, Tan; Valgimigli, Marco (2021-05-15)Aims: Choosing an antiplatelet strategy in patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS) at high bleeding risk (HBR), undergoing post-percutaneous coronary intervention (PCI), is complex. We ...