- UHRA Home
- Browsing by Author
Browsing by Author "Arkin, I.T."
Now showing items 1-9 of 9
-
Experimentally based orientational refinement of membrane protein models : a structure for the Influenza A M2 H+ channel
Kukol, A.; Adams, P.D.; Rice, L.M.; Brunger, A.T.; Arkin, I.T. (1999)The structure determination of membrane proteins is still a difficult task. Considering the fact that as many as 30% or more of cellular proteins are associated with the membrane (Arkin et al., 1997a), the paucity of high ... -
Exploring models of the influenza A M2 channel: MD simulations in a phospholipid bilayer
Forrest, L. R.; Kukol, A.; Arkin, I.T.; Tieleman, D. P.; Sansom, M. S. P. (2000-01)The M2 protein of influenza A virus forms homotetrameric helix bundles, which function as proton-selective channels. The native form of the protein is 97 residues long, although peptides representing the transmembrane ... -
Mapping the energy surface of transmembrane helix-helix interactions
Torres, J.; Kukol, A.; Arkin, I.T. (2001-11)Transmembrane helices are no longer believed to be just hydrophobic segments that exist solely to anchor proteins to a lipid bilayer, but rather they appear to have the capacity to specify function and structure. Specific ... -
Site-specific examination of secondary structure and orientation determination in membrane proteins: The peptidic C-13=O-18 group as a novel infrared probe
Torres, J.; Kukol, A.; Goodman, J. M.; Arkin, I.T. (2001-11)Detailed site-specific information can be exceptionally useful in structural studies of macromolecules in general and proteins in particular. Stich information is usually obtained from spectroscopic studies using a label/probe ... -
A Structure for the Trimeric MHC Class II-associated Invariant Chain Transmembrane Domain
Kukol, A.; Torres, J.; Arkin, I.T. (2002) -
The structure of the HIV-1 Vpu ion channel: modelling and simulation studies
Cordes, F. S.; Kukol, A.; Forrest, L. R.; Arkin, I.T.; Sansom, M. S. P.; Fischer, W. B. (2001-06-06)Vpu is an 81 amino acid auxiliary protein in HIV-1 which exhibits channel activity. We used two homo-pentameric bundles with the helical transmembrane segments derived from FTIR spectroscopy in combination with a global ... -
Structure of the Influenza C virus CM2 protein transmembrane domain obtained by site-specific infrared dichroism and global molecular dynamics searching
Kukol, A.; Arkin, I.T. (2000-02-11)The 115-residue protein CM2 from Influenza C virus has been recently characterized as a tetrameric integral membrane glycoprotein. infrared spectroscopy and site-directed infrared dichroism were utilized here to determine ... -
Use of a single glycine residue to determine the tilt and orientation of a transmembrane helix : A new structural label for infrared spectroscopy
Torres, J.; Kukol, A.; Arkin, I.T. (2000-12)Site-directed dichroism is an emerging technique for the determination of membrane protein structure. However, due to a number of factors, among which is the high natural abundance of C-13, the use of this technique has ... -
Vpu transmembrane peptide structure obtained by site-specific Fourier transform infrared dichroism and global molecular dynamics searching
Kukol, A.; Arkin, I.T. (1999-09)The recently developed method of site-directed Fourier transform infrared dichroism for obtaining orientational constraints of oriented polymers is applied here to the transmembrane domain of the vpu protein from the human ...