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Browsing by Author "Bountra, Chas"
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Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons
Anand, Uma; Otto, William R; Sanchez-Herrera, Daniel; Facer, Paul; Yiangou, Yiangos; Korchev, Yuri; Birch, Rolfe; Benham, Christopher; Bountra, Chas; Chessell, Iain P; Anand, Praveen (2008)Cannabinoid receptor 2 (CB2) agonists provide the potential for treating chronic pain states without CNS effects associated with CB1 receptor activation. Animal models suggest that they act mainly via non-neuronal cells, ... -
Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy
Facer, Paul; Casula, Maria A; Smith, Graham D; Benham, Christopher D; Chessell, Iain P; Bountra, Chas; Sinisi, Marco; Birch, Rolfe; Anand, Praveen (2007)Transient receptor potential (TRP) receptors expressed by primary sensory neurons mediate thermosensitivity, and may play a role in sensory pathophysiology. We previously reported that human dorsal root ganglion (DRG) ... -
Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy
Sánchez, Daniel; Anand, Uma; Gorelik, Julia; Benham, Christopher D; Bountra, Chas; Lab, Max; Klenerman, David; Birch, Rolfe; Anand, Praveen; Korchev, Yuri (2007)Mechanosensitive ion channels convert external mechanical force into electrical and chemical signals in cells, but their physiological function in different tissues is not clearly understood. One reason for this is that ...