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Browsing by Author "Carter, R. J."
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Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation
Murphy, K. P. S. J.; Carter, R. J.; Mangiarini, L.; Mahal, A.; Bates, G. P.; Dunnett, S.B.; Morton, A. J.; Lione, Lisa (2000-07-01)Huntington's disease (HD) is an autosomal dominant progressive and fatal neurodegenerative brain disorder caused by an expanded CAG/polyglutamine repeat in the coding region of the gene. Presymptomatic Huntington's disease ... -
Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation
Lione, Lisa; Carter, R. J.; Humby, T.; Mangiarini, L.; Mahal, A.; Bates, G. P.; Dunnett, S.B.; Morton, A. J. (1999-04-15)Transgenic mice expressing exon 1 of the human Huntington's disease (HD) gene carrying a 141-157 CAG repeat (line R6/2) develop a progressive neurological phenotype with motor symptoms resembling those seen in HD. We have ... -
Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation
Lione, Lisa; Carter, R. J.; Hunt, M. J.; Bates, G. P.; Morton, A. J.; Dunnett, S B (1999-12-01)Cognitive decline is apparent in the early stages of Huntington's disease and progressively worsens throughout the course of the disease. Expression of the human Huntington's disease mutation in mice (R6/2 line) causes a ...