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A 2-D π–π dimer model system to investigate structure-charge transfer relationships in rubrene
Chung, Sherlyn J; McHugh, Callum J.; Calvo-Castro, Jesus (2019-01-23)Rubrene (5,6,11,12-tetraphenyltetracene) is undoubtedly one of the best performing organic charge transfer mediating materials, with experimentally determined mobilities up to 40 cm2 V−1 s−1. Consequently, there has been ... -
2-oxothiazolidine-4-carboxylic acid inhibits vascular calcification via induction of glutathione synthesis
Patel, Jessal; Bourne, Lucie E; Thakur, Shori; Farrington, Kenneth; Gorog, Diana; Orriss, Isabel R; Baydoun, Anwar (2020-09-12)Arterial medial calcification (AMC), the deposition of hydroxyapatite in the medial layer of the arteries, is a known risk factor for cardiovascular events. Oxidative stress is a known inducer of AMC and endogenous ... -
3,4-methylenedioxymethamphetamine (ecstasy) inhibits dyskinesia expression and normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates
Iravani, Mahmoud M.; Jackson, M. J.; Kuoppamaki, M.; Smith, L. A.; Jenner, P. (2003-10-08)Ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] was shown to prolong the action of L-3,4-dihydroxyphenylalanine (L-DOPA) while suppressing dyskinesia in a single patient with Parkinson's disease (PD). The clinical basis ... -
3-Nitrotyrosine-dependent dopaminergic neurotoxicity following direct nigral administration of a peroxynitrite but not a nitric oxide donor
Iravani, Mahmoud M.; Haddon, C. O.; Rose, S.; Jenner, P. (2006-01-05)The presence of 3-nitrotyrosine (3-NT) adducts in Lewy bodies in Parkinson's disease suggests a role for nitrative stress in dopaminergic cell death. Whether this is a direct effect of increased nitric oxide (NO) formation ... -
[3H]2-(2-Benzofuranyl)-2-imidazoline : a new selective high affinity radioligand for the study of rabbit brain imidazoline I2 receptors
Lione, Lisa; Nutt, D.J.; Hudson, A.L. (1996-05)This is the first study characterising the binding of the new imidazoline I2 receptor selective radioligand [3H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) to rabbit brain membranes. [3H]2-BFI binding was found to be saturable ... -
4,4’-dimethylaminorex (‘4,4’-DMAR’; ‘Serotoni’) misuse; a web-based study
Loi, Barbara; Zloh, Mire; Antonietta, Maria; Corkery, John; Schifano, Fabrizio (2017-06-28)Background: 4,4′-DMAR (4,4’-dimethylaminorex; ‘Serotoni’) is a potent stimulant drug which has recently been associated with a number of fatalities in Europe. Over the last few years, online communities have emerged as ... -
5,6-Methylenedioxy-2-aminoindane : from laboratory curiosity to 'legal high'
Gallagher, C. T.; Assi, S.; Stair, J. L.; Fergus, S.; Corazza, Ornella; Corkery, John; Schifano, Fabrizio (2012-03-01)The fully synthetic 'legal high' 5,6-methylenedioxy-2-aminoindane (MDAI) is an analogue of 3,4-methylenedioxymethamphetamine. Although developed in the 1990s, it was not widely abused until 2010. However, mephedrone was ... -
Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation
Murphy, K. P. S. J.; Carter, R. J.; Mangiarini, L.; Mahal, A.; Bates, G. P.; Dunnett, S.B.; Morton, A. J.; Lione, Lisa (2000-07-01)Huntington's disease (HD) is an autosomal dominant progressive and fatal neurodegenerative brain disorder caused by an expanded CAG/polyglutamine repeat in the coding region of the gene. Presymptomatic Huntington's disease ... -
Abuse of Prescription Drugs in the Context of Novel Psychoactive Substances (NPS): A Systematic Review
Schifano, Fabrizio; Chiappini, Stefania; Corkery, John; Guirguis, Amira (2018-04-22)Recently, a range of prescription and over-the-counter drugs have been reportedly used as Novel Psychoactive Substances (NPS), due to their potential for abuse resulting from their high dosage/idiosyncratic methods of ... -
Accuracy of Diagnostic Judgments Using ICD-11 vs. ICD-10 Diagnostic Guidelines for Obsessive-Compulsive and Related Disorders
Kogan, Cary; Stein, Dan J.; Rebello, Tahilia; Keeley, Jared; Jacky Chan, K; Fineberg, Naomi; Fontenelle, Leonardo F.; Grant, Jon E; Matsunaga, Hisato; Blair Simpson, H; Thomsen, Per Hove; van den Heuvel, Odile; Veale, David; Grenier, Jean; Kulygina, Mayya; Matsumoto, Chihiro; Domínguez-Martínez, Tecelli; Stona, Anne-Claire (2020-08)Background: We report results of an internet-based field study evaluating the diagnostic guidelines for the newly introduced ICD-11 grouping of obsessive-compulsive and related disorders (OCRD). We examined accuracy of ... -
Action sequence learning, habits, and automaticity in obsessive-compulsive disorder
Banca, Paula; Herrojo Ruiz, Maria; Gonzalez-Zalba, Miguel Fernando; Biria, Marjan; Marzuki, Aleya A; Piercy, Thomas; Sule, Akeem; Fineberg, Naomi A; Robbins, Trevor W (2024-05-09)This study investigates the goal/habit imbalance theory of compulsion in obsessive-compulsive disorder (OCD), which postulates enhanced habit formation, increased automaticity, and impaired goal/habit arbitration. It ... -
Action-Outcome Knowledge Dissociates From Behavior in Obsessive-Compulsive Disorder Following Contingency Degradation
Vaghi, Matilde M; Cardinal, Rudolf N; Apergis-Schoute, Annemieke M; Fineberg, Naomi A; Sule, Akeem; Robbins, Trevor W (2019-02-01)BACKGROUND: In obsessive-compulsive disorder (OCD), actions persist despite being inappropriate to the situation and without relationship to the overall goal. Dysfunctional beliefs have traditionally been postulated to ... -
The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation
Iravani, Mahmoud M.; Leung, Clement C. M.; Sadeghian, Mona; Haddon, C. O.; Rose, Sarah; Jenner, P. (2005-07)Sustained reactive microgliosis may contribute to the progressive degeneration of nigral dopaminergic neurons in Parkinson's disease (PD), in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposed human and in non-human ... -
Acute Haemodynamic Changes During Haemodialysis Do Not Exacerbate Gut Hyperpermeability
Wong, Jonathan; Lenaerts, Kaatje; Meesters, Dennis; Olde Damink, Steven; Van Eijk, Hans; Vilar Hall, Enric; Farrington, Kenneth (2019-04-12)Introduction: The gastrointestinal tract is a potential source of inflammation in dialysis patients. In-vitro studies suggest breakdown of the gut barrier in uraemia leading to increased intestinal permeability and it is ... -
Adding quetiapine to SRI in treatment-resistant obsessive-compulsive disorder: a randomized controlled treatment study
Fineberg, Naomi; Sivakumaran, T.; Roberts, A.; Gale, T.M. (2005)This study aimed to determine the efficacy and tolerability of adding quetiapine to a serotonin reuptake inhibitor in treatment-resistant obsessive-compulsive disorder (OCD). Twenty-one adult treatment-resistant OCD patients ... -
Adherence Behavior in Subjects on Hemodialysis Is Not a Clear Predictor of Posttransplantation Adherence
Hucker, Abigail; Lawrence, Christopher; Sharma, Shivani; Farrington, Kenneth (2019-08-01)Introduction: Nonadherence is common in both hemodialysis (HD) and kidney transplant recipients and is a major risk factor for poor clinical outcomes. This retrospective study explored whether nonadherent HD patients become ... -
Adherence to prophylaxis in adolescents and young adults with severe haemophilia: A quantitative study with patients
Van Os, Sandra; Troop, Nicholas; Sullivan, Keith; Hart, Daniel (2017-01-19)Introduction: haemophilia is an inherited bleeding disorder caused by a deficiency in one of the blood coagulation factors. For people affected by severe haemophilia, the deficiency can cause spontaneous internal bleeding. ... -
Adjunctive therapies to reduce thrombotic events in patients with a history of myocardial infarction : role of vorapaxar
Farag, Mohamed; Patel, Hiten; Gorog, Diana A (2015-07-22)Acute myocardial infarction (AMI) is generally attributed to coronary atherothrombotic disease. Platelet activation is essential for thrombus formation and is thus an important target for pharmacological intervention to ... -
Advances in Problematic Usage of the Internet Research – A Narrative Review by Experts from the European Network for Problematic Usage of the Internet
Fineberg, Naomi; Menchon, Josè M; Hall, Natalie; Dell'Osso, Bernardo; Brand, Matthias; Potenza, Marc; Chamberlain, Samuel R; Cirnigliaro, Giovanna; Lochner, Christine; Billieux, Joël; Demetrovics, Zsolt; Rumpf, Hans Jürgen; Muller, Astrid; Castro-Calvo, Jesús; Hollander, Eric; Burkauskas, Julius; Grünblatt, Edna; Walitza, Susanne; Corazza, Ornella; King, Daniel L; Stein, Dan J.; Grant, Jon E; Pallanti, Stefano; Bowden-Jones, Henrietta; Van Ameringen, Michael; Ioannidis, Konstantinos; Carmi, Lior; Goudriaan, Anna E; Martinotti, Giovanni; Sales, Celia M; Jones, Julia; Gjoneska, Biljiana; Király, Orsolya; Benatti, Beatrice; Vismara, Matteo; Pellegrini, Lucas; Conti, Dario; Cataldo, Ilaria; Riva, Gianluigi M; Yücel, Murat; Flayelle, Maèva; Hall, Thomas; Griffiths, Morgan; Zohar, Joseph (2022-10-30)Global concern about problematic usage of the internet (PUI), and its public health and societal costs, continues to grow, sharpened in focus under the privations of the COVID-19 pandemic. This narrative review reports the ... -
Afferent hypersensitivity in a mouse model of post-inflammatory gut dysfunction : role of altered serotonin metabolism
Keating, Christopher; Beyak, M.; Foley, S.; Singh, G.; Marsden, C.; Spiller, R.; Grundy, D. (2008-09)Visceral hypersensitivity is an important clinical feature associated with irritable bowel syndrome which in some patients has been linked to prior infection. Here we employ an animal model in which transient infection ...