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Browsing by Author "Chau, David"
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Determination of Water Content in Dehydrated Mammalian Cells Using Terahertz Pulsed Imaging: A Feasibility Study
Chau, David; Dennis, Anthony; Lin, Hungyen; Zeitler, J Axel; Tunnacliffe, Alan (2016-02-01)Mammalian cells are involved in a range of biotechnological applications and more recently have been increasingly exploited in regenerative medicine. Critical to successful applications involving mammalian cells are their ... -
Diffusion through the ex vivo vitreal body - bovine, porcine, and ovine models are poor surrogates for the human vitreous
Shafaie, Sara; Hutter, Victoria; Brown, Marc; Cook, Michael; Chau, David (2018-10-25)The human vitreous humour is a complex gel structure whose composition and physical properties can vary considerably from person to person and also change with age. To date, the viscoelastic properties of the human vitreous ... -
Discovery of novel small molecule inhibitors of S100P, with in vitro anti-metastatic effects on pancreatic cancer cells
Camara, Ramatoulie; Ogbeni, Deborah; Gerstmann, Lisa; Ostovar, Mehrnoosh; Hurer, Ellie; Scott, Mark; Mahmoud, Nasir; Radon, Tomasz; Crnogorac-Jurcevic, Tatjana; Patel, Pryank; Mackenzie, Louise Susan; Chau, David; Kirton, Stewart; Rossiter, Sharon (2020-10-01)S100P, a calcium- binding protein, is known to advance tumor progression and metastasis in pancreatic and several other cancers. Herein is described the in silico identification of a putative binding pocket of S100P to ... -
Influence of surface geometry on the culture of human cell lines: a comparative study using flat, round-bottom and v-shaped 96 well plates
Shafaie, Sara; Hutter, Victoria; Brown, Marc; Cook, Michael; Chau, David (2017-10-30)In vitro cell based models have been invaluable tools for studying cell behaviour and for investigating drug disposition, toxicity and potential adverse effects of administered drugs. Within this drug discovery pipeline, ... -
Optimising poly(lactic-co-glycolic acid) microparticle fabrication using a Taguchi orthogonal array design-of-experiment approach
Mensah, Rosemond; Kirton, Stewart; Cook, Michael T.; Styliari, Ioanna Danai; Hutter, Victoria; Chau, David (2019-09-26)The objective of this study was to identify, understand and generate a Taguchi orthogonal array model for the formation of 10–50 μm microparticles with applications in topical/ocular controlled drug delivery. Poly(lactic ...