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3-Methoxy-Phencyclidine Induced Psychotic Disorder: A Literature Review and an 18 F-FDG PET/CT Case Report
Pepe, Maria; Di Nicola, Marco; Cocciolillo, Fabrizio; Chiappini, Stefania; Martinotti, Giovanni; Calcagni, Maria Lucia; Sani, Gabriele (2024-03-31)New Psychoactive Substances (NPS) are modifying the drug scenario worldwide and have become a public health concern because of their toxicological profiles and their harmful physical/psychological effects. 3-Methoxy-Phencyclidine ... -
Abuse of Prescription Drugs in the Context of Novel Psychoactive Substances (NPS): A Systematic Review
Schifano, Fabrizio; Chiappini, Stefania; Corkery, John; Guirguis, Amira (2018-04-22)Recently, a range of prescription and over-the-counter drugs have been reportedly used as Novel Psychoactive Substances (NPS), due to their potential for abuse resulting from their high dosage/idiosyncratic methods of ... -
Alprazolam-related deaths in Scotland, 2004-2020
Corkery, John Martin; Guirguis, Amira; Chiappini, Stefania; Martinotti, Giovanni; Schifano, Fabrizio (2022-09-27)Background: The benzodiazepine drug alprazolam, a fast-acting tranquiliser, cannot be prescribed on the National Health Service in the United Kingdom. Illicit alprazolam supply and consumption have increased. Concern about ... -
Are finasteride-related penile curvature/Peyronie’s disease Adverse Event Reports worthy of further clinical investigation? Disproportionality analysis based on both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) pharmacovigilance databases
Schifano, Nicolo; Cappogrosso, Paolo; Boeri, Luca; Fallara, Guiseppe; Chiappini, Stefania; Rewhorn, Matthew; Cakir, Omer Onur; Harvey, Hannah; Castiglione, Fabio; Alnajjar, Hussain; Muneer, Asif; Deho, Frederico; Schifano, Fabrizio; Montorsi, Francesco; Salonia, Andrea (2022-05-05)A limited number of studies have described patients on finasteride showing findings which were consistent with Peyronie’s disease (PD). We aimed to detect a pharmacovigilance signal of possible association between finasteride ... -
Assessing the Extent and Characteristics of Non-medical Use of a Range of Prescribed Drugs: Epidemiological and Pharmacovigilance Approaches
Chiappini, Stefania (2022-07-14)Introduction: In the last ten years, the growing use of prescription and over-the-counter (OTC) drugs for recreational purposes has been observed. The use of ‘psychoactive pharmaceuticals’ and ‘pharming’ are new widespread ... -
Beyond the Purple Drank. Study of promethazine abuse according to the European Medicines Agency (EMA) Adverse Drug Reactions (ADR) reports.
Chiappini, Stefania; Schifano, Fabrizio; Corkery, John Martin; Guirguis, Amira (2021-01-10)Background: Promethazine is a medicinal product, available on its own or in combination with other ingredients including dextromethorphan, paracetamol, and/or expectorants. Anecdotal reports have however indicated that ... -
Brexpiprazole as a new approach of treatment in somatization disorder
Chiappini, Stefania; Mosca, Alessio; Martinotti, Giovanni; Di Carlo, Francesco; Miuli, Andrea; Dattoli, Luigi; Pettorruso, Mauro; Di Giannantonio, Massimo (2022-01-27)Introduction: Somatic symptom disorder (SSD) is a mental disorder that involves one or more physical symptoms (e.g. palpitations, dizziness, diarrhoea, limb weakness, pain, and pseudo neurological symptoms) accompanied by ... -
Cannabidiol (CBD) Use in Psychiatric Disorders; A Systematic Review
Bonaccorso, Stefania; Ricciardi, Angelo; Zangani, Caroline; Chiappini, Stefania; Schifano, Fabrizio (2019-09)Cannabidiol (CBD) and ∆9-tetrahydrocannabinol (THC) are the most represented phytocannabinoids in Cannabis sativa plants. However, CBD may present with a different activity compared with the psychotomimetic THC. Most ... -
Club Drugs and Psychiatric Sequelae: An Issue of Vulnerability and Previous Psychiatric History
Martinotti, Giovanni; Del Villar, Cristina Merino; Cordoba, Andrés Garcia; Tubau, Lluís Andrés; Sánchez, Ivan Castro; Di Carlo, Francesco; Chiappini, Stefania; Pettorruso, Mauro; Schifano, Fabrizio; Di Giannantonio, Massimo (2021-06-29)The pursuit of pleasure among clubbers and disco-goers often involves drug use. However, whether substance use may represent a relevant risk factor contributing to the development of psychiatric symptoms and of mental ... -
COVID-19: The hidden impact on mental health and drug addiction
Chiappini, Stefania; Guirguis, Amira; John, Ann; Corkery, John; Schifano, Fabrizio (2020-07-29)There is concern the Coronavirus Disease (COVID)-19 pandemic is having a negative impact on the mental health of the general population through a range of suggested mechanisms: fear, uncertainty, and anxiety; social ... -
A Decade of Gabapentinoid Misuse: : An Analysis of the European Medicines Agency’s ‘Suspected Adverse Drug Reactions’ Database
Chiappini, Stefania; Schifano, Fabrizio (2016-06-16)Introduction: The gabapentinoids pregabalin and gabapentin are being increasingly prescribed for a range of clinical conditions. Recently, although gabapentinoids at therapeutic dosages may present with low addictive ... -
Duration of Untreated Disorder and Cannabis Use: An Observational Study on a Cohort of Young Italian Patients Experiencing Psychotic Experiences and Dissociative Symptoms
Ricci, Valerio; Martinotti, Giovanni; Ceci, Franca; Chiappini, Stefania; Di Carlo, Francesco; Burkauskas, Julius; Susini, Ottavia; Luciani, Debora; Quattrone, Diego; De Berardis, Domenico; Pettorruso, Mauro; Maina, Giuseppe; Di Giannantonio, Massimo (2021-11-30)Background: The Duration of Untreated Psychosis (DUP) is the time between the first-episode psychosis (FEP) and the initiation of antipsychotic treatment. It is an important predictor of several disease-related outcomes ... -
Editorial: Misuse and abuse of prescription drugs in custodial settings
Perani, Filippo; Chiappini, Stefania; Schifano, Fabrizio; Giorgetti, Arianna (2023-11-30) -
Editorial: Prescribing Psychotropics: Misuse, Abuse, Dependence, Withdrawal and Addiction
Chiappini, Stefania; Schifano, Fabrizio; Martinotti, Giovanni (2021-04-30) -
Esketamine in treatment-resistant depression patients comorbid with substance-use disorder: A viewpoint on its safety and effectiveness in a subsample of patients from the REAL-ESK study
Chiappini, Stefania; Martinotti, Giovanni (2023-09-30)Esketamine, the S-enantiomer of ketamine, has recently emerged as a therapy for treatment-resistant depression (TRD), showing both rapid antidepressant action and good efficacy and high safety. It is also indicated for the ... -
Exploring the Nexus of Binge Eating Disorder (BED), New Psychoactive Substances (NPS), and Misuse of Pharmaceuticals: Charting a Path Forward
Chiappini, Stefania; Papanti Pelletier, G. Duccio; Vickers-Smith, Rachel; Corkery, John; Guirguis, Amira; Martinotti, Giovanni; Schifano, Fabrizio (2023-10-31) -
A Focus on Abuse/Misuse and Withdrawal Issues with Selective Serotonin Reuptake Inhibitors (SSRIs): Analysis of Both the European EMA and the US FAERS Pharmacovigilance Databases
Chiappini, Stefania; Vickers-Smith, Rachel; Guirguis, Amira; Corkery, John Martin; Martinotti, Giovanni; Schifano, Fabrizio (2022-05-01)Despite increasing reports, antidepressant (AD) misuse and dependence remain underestimated issues, possibly due to limited epidemiological and pharmacovigilance evidence. Thus, here we aimed to determine available ... -
Focus on over-the-counter drugs’ misuse; a systematic review on antihistamines, cough medicines and decongestants
Schifano, Fabrizio; Chiappini, Stefania; Miuli, Andrea; Santovito, Monica Chiara; Mosca, Alessio; Santovito, Maria Chiara; Corkery, John Martin; Guirguis, Amira; Pettorruso, Mauro; di Giannantonio, Massimo; Martinotti, Giovanni (2021-05-07)Background: Over the past 20 years or so the drug misuse scenario has seen the emergence of both prescription-only and over-the-counter (OTC) medications being reported as ingested for recreational purposes. OTC drugs such ... -
Focus on over-the-counter drugs’ misuse; a systematic review on antihistamines, cough medicines and decongestants
Schifano, Fabrizio; Chiappini, Stefania; Miuli, Andrea; Santovito, Monica Chiara; Mosca, Alessio; Santovito, Maria Chiara; Corkery, John Martin; Guirguis, Amira; Pettorruso, Mauro; di Giannantonio, Massimo; Martinotti, Giovanni (2021-05-07)Background: Over the past 20 years or so the drug misuse scenario has seen the emergence of both prescription-only and over-the-counter (OTC) medications being reported as ingested for recreational purposes. OTC drugs such ... -
Focus on over-the-counter drugs’ misuse; a systematic review on antihistamines, cough medicines and decongestants
Schifano, Fabrizio; Chiappini, Stefania; Miuli, Andrea; Santovito, Monica Chiara; Mosca, Alessio; Santovito, Maria Chiara; Corkery, John Martin; Guirguis, Amira; Pettorruso, Mauro; di Giannantonio, Massimo; Martinotti, Giovanni (2021-05-07)Background: Over the past 20 years or so the drug misuse scenario has seen the emergence of both prescription-only and over-the-counter (OTC) medications being reported as ingested for recreational purposes. OTC drugs such ...