Browsing by Author "Choi, Ji-Won"

Now showing items 1-2 of 2

    • PEGylation of native disulfide bonds in proteins 

      Brocchini, Steve; Balan, Sibu; Godwin, Antony; Choi, Ji-Won; Zloh, Mire; Shaunak, Sunil (2006)
      PEGylation has turned proteins into important new biopharmaceuticals. The fundamental problems with the existing approaches to PEGylation are inefficient conjugation and the formation of heterogeneous mixtures. This is ...

    • Site-specific PEGylation of native disulfide bonds in therapeutic proteins 

      Shaunak, Sunil; Godwin, Antony; Choi, Ji-Won; Balan, Sibu; Pedone, Elisa; Vijayarangam, Damotharan; Heidelberger, Sibylle; Teo, Ian; Zloh, Mire; Brocchini, Steve (2006)
      Native disulfide bonds in therapeutic proteins are crucial for tertiary structure and biological activity and are therefore considered unsuitable for chemical modification. We show that native disulfides in human interferon ...