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Browsing by Author "Cirino, G."
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Anti-thrombotic effects of a nitric-oxide-releasing, gastric-sparing aspirin derivative
Wallace, J. L.; McKnight, W.; Del Soldato, P.; Baydoun, A. R.; Cirino, G. (1995)Effects of a nitroxybutylester derivative of aspirin (NCX 4215) on platelet aggregation and prostanoid synthesis were compared to the effects of aspirin. NCX 4215 was approximately seven times more potent than aspirin as ... -
Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR) is involved in vascular function
Bucci, M.; Vellecco, V.; Brancaleone, V.; Roviezzo, F.; Mattace Raso, G.; Ianaro, A.; Meli, R.; Cirino, G.; Harrington, L.; Lungarella, G.; De Palma, R. (2013)Background and Purpose Proteinase-activated receptors (PARs) and toll-like receptors (TLRs) are involved in innate immune responses. The aim of this study was to evaluate the possible cross-talk between PAR and TLR4 in ... -
Effects of Endothelin-1 on the Rat Isolated Heart
Baydoun, A. R.; Peers, S.H.; Cirino, G.; Woodward, B. (1989) -
Flurbinitroxybutylester : a novel anti-inflammatory drug has enhanced antithrombotic activity
Cirino, G.; Cicala, C.; Mancuso, F.; Baydoun, A. R.; Wallace, J. L. (1995)We have recently shown that the introduction of a nitroxybutylester moiety into flurbiprofen, to form Flurbi-NO, results in a compound with markedly reduced undesired effects in the gastrointestinal tract. This effect has ... -
Inhibition of inducible nitric oxide synthase expression by novel nonsteroidal anti-inflammatory drugs with nitroxy moiety
Cirino, G.; Wheeler-Jones, C.P.D.; Wallace, J. L.; Del Soldato, P.; Baydoun, A. R. (1996)Effects of novel nitric oxide-releasing nonsteroidal anti-inflammatory compounds (NONSAIDs) on induction of nitric oxide (NO) synthase by bacterial lipopolysaccharide (LPS) were examined in a cultured murine macrophage ... -
Vasodilator action of endothelin-1 in the perfused rat heart
Baydoun, A. R.; Peers, S.H.; Cirino, G.; Woodward, R. (1990)