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Browsing by Author "Crowther, G. S."
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Evaluation of the effect of oritavancin on Clostridium difficile spore germination, outgrowth and recovery
Chilton, C. H.; Freeman, J.; Baines, Simon D.; Crowther, G. S.; Nicholson, S.; Wilcox, M. H. (2013)OBJECTIVES: Previous work suggests oritavancin may be inhibitory to Clostridium difficile spores. We have evaluated the effects of oritavancin exposure on C. difficile spore germination, outgrowth and recovery. METHODS: ... -
In vitro activity of cadazolid against clinically relevant Clostridium difficile isolates and in an in vitro gut model of C. difficile infection
Chilton, C. H.; Crowther, G. S.; Baines, Simon D.; Todhunter, S. L.; Freeman, J.; Locher, H. H.; Athanasiou, A.; Wilcox, M. H. (2013-10-14)Abstract Objectives We investigated the in vitro activity of cadazolid against 100 Clostridium difficile isolates and its efficacy in a simulated human gut model of C. difficile infection (CDI). Methods MICs of cadazolid, ... -
SMT19969 as a treatment for Clostridium difficile infection : an assessment of antimicrobial activity using conventional susceptibility testing and an in vitro gut model
Baines, Simon D.; Crowther, G. S.; Freeman, J.; Todhunter, S.; Vickers, R.; Wilcox, M. H. (2015-01-01)OBJECTIVES: We investigated the efficacy of the novel antimicrobial agent SMT19969 in treating simulated Clostridium difficile infection using an in vitro human gut model. METHODS: Concentrations of the predominant cultivable ...