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Browsing by Author "Dalton, C. H."
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Clinical manifestations of VX poisoning following percutaneous exposure in the domestic white pig
Chilcott, Robert; Dalton, C. H.; Hill, I.; Davidson, C. M.; Blohm, K. L.; Hamilton, M. G. (2003-05)Nerve agents are a class of organophosphorus chemicals that inhibit certain cholinesterase enzymes (ChE). If untreated, percutaneous exposure to nerve agents, such as VX (O-ethyl-S-[2(diisopropylamino)ethyl] methylphosph ... -
Closed cup vapor systems in percutaneous exposure studies : What is the dose?
Dalton, C. H.; Maidment, Michael P.; Jenner, J.; Chilcott, Robert (2006-04)Percutaneous vapor dosing studies have generally used saturated vapor concentration (SVC) measurements to estimate the exposure dose (Ct) of vapor produced from a volatile liquid within a closed system. The purpose of this ... -
Evaluation of a barrier cream against the chemical warfare agent VX using the domestic white pig
Chilcott, Robert; Dalton, C. H.; Hill, I.; Davison, C. M.; Blohm, K. L.; Clarkson, E. D.; Hamilton, M. G. (2005-07)The purpose of this study was to evaluate the efficacy of a novel barrier cream formulation at reducing the percutaneous toxicity of a 2xLD(50) liquid challenge of nerve agent (VX). The study was conducted in vitro and in ... -
Exposure to UVB radiation does not directly impair skin barrier function
Dalton, C. H.; Chilcott, Robert (2001-11-01) -
In vivo skin absorption and distribution of the nerve agent VX (O-ethyl-S-[2(diisopropylamino)ethyl] methylphosphonothioate) in the domestic white pig
Chilcott, Robert; Dalton, C. H.; Hill, I.; Davison, C. M.; Blohm, K. L.; Clarkson, E. D.; Hamilton, M. G. (2005-07)The purpose of this study was to characterize the skin absorption and distribution of VX (O-ethyl-S-[2 (diisopropylamino)ethyl] methylphosphonothioate) in the domestic pig in order to evaluate the animal as a potential ... -
Transepidermal water loss does not correlate with skin barrier function in vitro
Chilcott, Robert; Dalton, C. H.; Emmanuel, A. J.; Allen, C. E.; Bradley, S. T. (2002-05)The purpose of this study was to investigate the relationship between transepidermal water loss and skin permeability to tritiated water ((H2O)-H-3) and the lipophilic penetrant sulfur mustard in vitro . No correlation was ...