Browsing by Author "Dimitriadi, Maria"

Now showing items 1-10 of 10

    • Autophagy in spinal muscular atrophy: from pathogenic mechanisms to therapeutic approaches 

      Rashid, Saman; Dimitriadi, Maria (2024-01-08)
      Spinal muscular atrophy (SMA) is a devastating neuromuscular disorder caused by the depletion of the ubiquitously expressed survival motor neuron (SMN) protein. While the genetic cause of SMA has been well documented, the ...

    • C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins 

      Anderson, Edward N.; Corkins, Mark E.; Li, Jia Cheng; Singh, Komudi; Parsons, Sadé; Tucey, Tim M.; Sorkaç, Altar; Huang, Huiyan; Dimitriadi, Maria; Sinclair, David A.; Hart, Anne C. (2016-03-01)
      Moderate stress can increase lifespan by hormesis, a beneficial low-level induction of stress response pathways. 5'-fluorodeoxyuridine (FUdR) is commonly used to sterilize Caenorhabditis elegans in aging experiments. ...

    • Decreased function of survival motor neuron protein impairs endocytic pathways 

      Dimitriadi, Maria; Derdowski, Aaron; Kalloo, Geetika; Maginnis, Melissa S; O'Hern, Patrick; Bliska, Bryn; Sorkaç, Altar; Nguyen, Ken C Q; Cook, Steven J; Poulogiannis, George; Atwood, Walter J; Hall, David H; Hart, Anne C (2016-07-26)
      Spinal muscular atrophy (SMA) is caused by depletion of the ubiquitously expressed survival motor neuron (SMN) protein, with 1 in 40 Caucasians being heterozygous for a disease allele. SMN is critical for the assembly of ...

    • Developing microfluidic platforms for rapid identification of new targets for neurodegenerative disorders 

      Pacheco Torres, Paloma; Kaye, Richard; Johnston, Ian; Dimitriadi, Maria; Tan, Christabel (2023-10-19)

    • Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy 

      Walsh, Melissa B.; Janzen, Eva; Wingrove, Emily; Hosseinibarkooie, Seyyedmohsen; Rodriguez Muela, Natalia; Davidow, Lance; Dimitriadi, Maria; M. Norabuena, Erika; L Rubin, Lee; Wirth, Brunhilde; C. Hart, Anne (2020-09-16)
      Background: Understanding the genetic modifiers of neurodegenerative diseases can provide insight into the mechanisms underlying these disorders. Here, we examine the relationship between the motor neuron disease spinal ...

    • Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review 

      Bassin, Jatinder; Dimitriadi, Maria; Cook, Michael T.; Abelha, Thais Fedatto; Calvo-Castro, Jesus (2022-09-19)
      The last decade has seen an increasingly large number of studies reporting on the development of novel small organic conjugated systems for mitochondrial imaging exploiting optical signal transduction pathways. Mitochondria ...

    • Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis 

      Riessland, Markus; Kaczmarek, Anna; Schneider, Svenja; Swoboda, Kathryn J; Löhr, Heiko; Bradler, Cathleen; Grysko, Vanessa; Dimitriadi, Maria; Hosseinibarkooie, Seyyedmohsen; Torres-Benito, Laura; Peters, Miriam; Upadhyay, Aaradhita; Biglari, Nasim; Kröber, Sandra; Hölker, Irmgard; Garbes, Lutz; Gilissen, Christian; Hoischen, Alexander; Nürnberg, Gudrun; Nürnberg, Peter; Walter, Michael; Rigo, Frank; Bennett, C Frank; Kye, Min Jeong; Hart, Anne C; Hammerschmidt, Matthias; Kloppenburg, Peter; Wirth, Brunhilde (2017-02-02)
      Homozygous SMN1 loss causes spinal muscular atrophy (SMA), the most common lethal genetic childhood motor neuron disease. SMN1 encodes SMN, a ubiquitous housekeeping protein, which makes the primarily motor neuron-specific ...

    • Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation 

      Tape, Christopher J.; Ling, Stephanie; Dimitriadi, Maria; McMahon, Kelly M.; Worboys, Jonathan D.; Leong, Hui Sun; Norrie, Ida C.; Miller, Crispin J.; Poulogiannis, George; Lauffenburger, Douglas A.; Jørgensen, Claus (2016-05-05)
      Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells. Here, we show that oncogenic KRAS (KRAS(G12D)) also regulates tumor cell signaling via stromal cells. By combining cell-specific ...

    • PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation 

      Gupta, Amit; Anjomani-Virmouni, Sara; Koundouros, Nikos; Dimitriadi, Maria; Choo-Wing, Rayman; Valle, Adamo; Zheng, Yuxiang; Chiu, Yu-Hsin; Agnihotri, Sameer; Zadeh, Gelareh; Asara, John M; Anastasiou, Dimitrios; Arends, Mark J; Cantley, Lewis C; Poulogiannis, George (2017-03-16)
      PARK2 is a gene implicated in disease states with opposing responses in cell fate determination, yet its contribution in pro-survival signaling is largely unknown. Here we show that PARK2 is altered in over a third of all ...

    • Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration 

      Baskoylu, Saba N; Yersak, Jill; O'Hern, Patrick; Grosser, Sarah; Simon, Jonah; Kim, Sarah; Schuch, Kelsey; Dimitriadi, Maria; Yanagi, Katherine S; Lins, Jeremy; Hart, Anne C (2018-10-08)
      Mutations in Cu/Zn superoxide dismutase 1 (SOD1) lead to Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease that disproportionately affects glutamatergic and cholinergic motor neurons. Previous work with SOD1 ...