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Browsing by Author "Extracellular Vesicle Research Unit"
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Animal Models of Human Disease
Lange, Sigrun; Inal, Jameel (2023-10-31)The use of animal models of human disease is critical for furthering our understanding of disease mechanisms, for the discovery of novel targets for treatment, and for translational research. This Special Topic entitled ... -
Antibody Drug Conjugates in Urological Cancers: A Review of the Current Landscape
Ghose, Aruni; Lapitan, Patricia; Apte, Vedika; Ghosh, Adheesh; Kandala, Abhinav; Basu, Sreejana; Parkes, Jo; Shinde, Sayali D; Boussios, Stergios; Sharma, Anand; Das, Prantik; Vasdev, Nikhil; Rebuzzi, Sara E; Ürün, Yüksel; Kanesvaran, Ravindran; Maniam, Akash; Banna, Giuseppe L (2024-04-23)Purpose of Review Our review delves into the progress across urological malignancies and discusses ongoing challenges and future directions in antibody–drug conjugate (ADC) development, emphasising their transformative ... -
Antisense PNA accumulates in Escherichia coli and mediates a long post-antibiotic effect
Nikravesh, Abbas; Dryselius, Rikard; Faridani, Omid R; Goh, Shan; Sadeghizadeh, Majid; Behmanesh, Mehrdad; Ganyu, Anita; Klok, Erik Jan; Zain, Rula; Good, Liam (2007-08-01)Antisense agents that target growth-essential genes display surprisingly potent bactericidal properties. In particular, peptide nucleic acid (PNA) and phosphorodiamidate morpholino oligomers linked to cationic carrier ... -
Applications of artificial intelligence for benign prostatic conditions
Bansal, Saakshi; Chuluunbaatar, Yanjinlkham; Brodie, Andrew; Vasdev, Nikhil (2023-06-30)The advancement of computational abilities have taken us from the days of machines performing simple, one dimensional tasks, to themselves learning and applying knowns to unknowns. Artificial intelligence (AI) has become ... -
Applied Methods to Assess the Antimicrobial Activity of Metallic-Based Nanoparticles
Chung, Etelka; Ren, Guogang; Johnston, Ian; Matharu, Rupy Kaur; Ciric, Lena; Walecka, Agnieszka; Cheong, Yuen-Ki (2023-10-28)With the rise of antibiotic resistance, the drive to discover novel antimicrobial substances and standard testing methods with the aim of controlling transmissive diseases are substantially high. In healthcare sectors and ... -
Artificial Intelligence in Urological Oncology: An update and future applications
Brodie, Andrew; Dairu, Dai; Teoh, Jeremy; Decaestecker, Karel; Dasgupta, Prokar; Vasdev, Nikhil (2021-05-20)There continues to be rapid developments and research in the field of Artificial Intelligence (AI) in Urological Oncology worldwide. In this review we discuss the basics of AI, application of AI per tumour group (Renal, ... -
Autophagy in spinal muscular atrophy: from pathogenic mechanisms to therapeutic approaches
Rashid, Saman; Dimitriadi, Maria (2024-01-08)Spinal muscular atrophy (SMA) is a devastating neuromuscular disorder caused by the depletion of the ubiquitously expressed survival motor neuron (SMN) protein. While the genetic cause of SMA has been well documented, the ... -
Biomarkers in Bladder Cancer Surveillance
Sugeeta, Sukumar S.; Sharma, Anand; Ng, Kenrick; Nayak, Arvind; Vasdev, Nikhil (2021-09-28)Aim: This is a narrative review with an aim to summarise and describe urinary biomarkers in the surveillance of non-muscle-invasive bladder cancer (NMIBC). It provides a summary of FDA-approved protein biomarkers along ... -
Biomarkers in Bladder Cancer Survellance
Sugeeta, SS; Sharma, A.; Ng, K; Nayak, A; Vasdev, Nikhil (2021-09-28)Aim: This is a narrative review with an aim to summarise and describe urinary biomarkers in the surveillance of non-muscle-invasive bladder cancer (NMIBC). It provides a summary of FDA-approved protein biomarkers along ... -
Blue light transurethral resection and biopsy of bladder cancer with hexaminolevulinate: Histopathological characteristics and recurrence rates in a single UK centre study
Chan, Kimberley; Hampson, Alexander; Hayes, John; Rabinowitz, Joshua; Vasdev, Nikhil (2023-09-30)Introduction: Blue light cystoscopy with hexaminolevulinate (HAL) during transurethral resection of bladder cancer (TURBT) has been shown to improve detection, thereby reducing bladder cancer recurrence compared with white ... -
C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins
Anderson, Edward N.; Corkins, Mark E.; Li, Jia Cheng; Singh, Komudi; Parsons, Sadé; Tucey, Tim M.; Sorkaç, Altar; Huang, Huiyan; Dimitriadi, Maria; Sinclair, David A.; Hart, Anne C. (2016-03-01)Moderate stress can increase lifespan by hormesis, a beneficial low-level induction of stress response pathways. 5'-fluorodeoxyuridine (FUdR) is commonly used to sterilize Caenorhabditis elegans in aging experiments. ... -
C2 by-pass: Cross-talk between the complement classical and alternative pathways
Laich, A; Patel, H; Zarantonello, A; Sim, R B; Inal, J M (2022-05-31)Several disorders associated with the total or partial absence of components of the human complement system are known. Deficiencies of classical pathway (CP) components are generally linked to systemic lupus erythematosus ... -
Cannabidiol (CBD) is a novel inhibitor for exosome and microvesicle (EMV) release in cancer
Kosgodage, Uchini S; Mould, Rhys; Henley, Aine; Nunn, alistair; Guy, Geoffrey; Thomas, E. Louise; Inal, Jameel; Bell, Jimmy; Lange, Sigrun (2018-08-13)Exosomes and microvesicles (EMV) are lipid bilayer-enclosed structures, released by cells and involved in intercellular communication through transfer of proteins and genetic material. EMV release is also associated with ... -
Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells
Kosgodage, Uchini S; Uysal-Onganer, Pinar; MacLatchy, Amy; Mould, Rhys; Nunn, Alistair; Guy, Geoffrey; Kraev, Igor; Chatterton, Nicholas; Inal, Jameel; Thomas, E. Louise; Bell, Jimmy; Lange, Sigrun (2019-03-01)Glioblastoma multiforme (GBM) is the most common and aggressive form of primary malignant brain tumor in adults, with poor prognosis. Extracellular vesicles (EVs) are key-mediators for cellular communication through transfer ... -
Cannabidiol Is a Novel Modulator of Bacterial Membrane Vesicles
Kosgodage, Uchini S; Matewele, Paul; Awamaria, Brigitte; Kraev, Igor; Warde, Purva; Mastroianni, Giulia; Nunn, alistair; Guy, Geoffrey; Bell, Jimmy; Inal, Jameel; Lange, Sigrun (2019-09-10)Membrane vesicles (MVs) released from bacteria participate in cell communication and host-pathogen interactions. Roles for MVs in antibiotic resistance are gaining increased attention and in this study we investigated if ... -
The clinical and financial implications of a decade of prostate biopsies in the NHS : analysis of Hospital Episode Statistics data 2008–2019
Tamhankar, Ashwin Sunil; El-Taji, Omar; Vasdev, Nikhil; Foley, Charlotte; Popert, Rick; Adshead, Jim (2020-04-22)Objective: To evaluate the clinical and financial implications of a decade of prostate biopsies performed in the UK National Health Service (NHS) through the transrectal (TR) vs the transperineal (TP) route. Methods: We ... -
Clinical outcomes of low‑pressure pneumoperitoneum in minimally invasive urological surgery
West, Alexander; Hayes, John; Bernstein, D E; Krishnamoorthy, Mahesh; Lathers, Steven; Tegan, Gary; Teoh, Jeremy Yuen-Chun; Dasgupta, Prokar; Decaestecker , Karel; Vasdev, Nikhil (2022-01-30)The adoption of minimally invasive laparoscopic techniques has revolutionised urological practice. This necessitates a pneumoperitoneum (PNP) and the impact the PNP pressure has on post-operative outcomes is uncertain. ... -
Comparative study between the use of double J ureteric stents vs bander ureteric stents during robotic assisted radical cystectomy with intra corporeal ileal conduit urinary diversion
Ibrahim, Mohamed; Nayak, Arvind; Patel, Amit; Brodie, Andrew; Decaestecker, Karel; Teoh, Jeremy Yuen-Chun; Vasdev, Nikhil (2024-01-10)Robotic-assisted radical cystectomy (RARC) is fast becoming the standard of care with comparable oncological outcomes to open surgery for patients with muscle-invasive bladder cancer. Ileal conduit is by far the most popular ... -
Comparing different pneumoperitoneum (12 Vs 15 mm Hg) pressures with cytokine analysis to evaluate clinical outcomes in patients undergoing Robotic-Assisted Laparoscopic Radical Cystectomy and Intra-Corporeal Robotic Urinary Diversion
Vasdev, Nikhil; Martin, Naomi; Hackney, Amon B.; Piedad, John; Hampson, Alexander; Gowrie-Mohan, Shan; Prasad, Venkat; Chilvers, Michael; Ebon, Martin; Smith, Philip; Tegan, Gary; Decaestecker, Karel; Baydoun, Anwar (2023-04-11)Background Robotic cystectomy is the mainstay surgical intervention for treatment-refractory non-muscle-invasive and muscle-invasive bladder cancer. However, paralytic ileus complicates the post-operative recovery, and may ... -
Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections
McFarland, Lynne Vernice; Ozen, Metehan; Dinleyici, Ener Cagri; Goh, Shan (2016-03-21)Antibiotic-associated diarrhea (AAD) and Clostridium difficile infections (CDI) have been well studied for adult cases, but not as well in the pediatric population. Whether the disease process or response to treatments ...